IL1RL2

IL1RL2
Identifiers
Aliases	IL1RL2, IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, interleukin 1 receptor like 2
External IDs	OMIM: 604512; MGI: 1913107; HomoloGene: 2860; GeneCards: IL1RL2; OMA:IL1RL2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,240,002 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,406,722 bp
RNA expression pattern
	Top expressed in
	testicle; ; skin of abdomen; ; skin of leg; ; right lobe of thyroid gland; ; right lobe of liver; ; cartilage tissue; ; left lobe of thyroid gland; ; right uterine tube; ; minor salivary glands; ; mucosa of transverse colon;
	Top expressed in
	lip; ; conjunctival fornix; ; gastrula; ; skin of external ear; ; skin of back; ; seminal vesicula; ; esophagus; ; epidermis; ; hair follicle; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-1, type I, activating receptor activity; interleukin-1 receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	positive regulation of T cell differentiation; immune system process; interleukin-1-mediated signaling pathway; cellular defense response; innate immune response; inflammatory response; signal transduction; regulation of inflammatory response; positive regulation of interleukin-6 production; cytokine-mediated signaling pathway; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	8808
	107527
	ENSG00000115598
	ENSMUSG00000070942
	Q9HB29
	Q9ERS7
NM_003854; NM_001351446; NM_001351447; NM_001351448; NM_001351449;
	NM_001351450
	NM_133193; NM_001356478
NP_003845; NP_001338375; NP_001338376; NP_001338377; NP_001338378;
	NP_001338379
	NP_573456; NP_001343407
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115598 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070942 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Dec 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.113-22&rft.date=1996-12&rft_id=https://api.semanticscholar.org/CorpusID:53171191#id-name=S2CID&rft_id=info:pmid/8898719&rft_id=info:doi/10.1016/S0165-5728(96)50047-1&rft.aulast=Lovenberg&rft.aufirst=TW&rft.au=Crowe, PD&rft.au=Liu, C&rft.au=Chalmers, DT&rft.au=Liu, XJ&rft.au=Liaw, C&rft.au=Clevenger, W&rft.au=Oltersdorf, T&rft.au=De Souza, EB&rft.au=Maki, RA&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">
^ Dale M, Nicklin MJ (Jun 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.177-9&rft.date=1999-06&rft_id=info:doi/10.1006/geno.1999.5767&rft_id=info:pmid/10191101&rft.aulast=Dale&rft.aufirst=M&rft.au=Nicklin, MJ&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">
^ Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (Jul 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.1440-6&rft.date=2001-07&rft_id=info:doi/10.4049/jimmunol.167.3.1440&rft_id=info:pmid/11466363&rft.aulast=Debets&rft.aufirst=R&rft.au=Timans, JC&rft.au=Homey, B&rft.au=Zurawski, S&rft.au=Sana, TR&rft.au=Lo, S&rft.au=Wagner, J&rft.au=Edwards, G&rft.au=Clifford, T&rft.au=Menon, S&rft.au=Bazan, JF&rft.au=Kastelein, RA&rft_id=https://doi.org/10.4049%2Fjimmunol.167.3.1440&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">
^ ^a ^b "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".

McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184.2821-32&rft.date=1991&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC452992#id-name=PMC&rft_id=info:pmid/1833184&rft_id=info:doi/10.1002/j.1460-2075.1991.tb07831.x&rft.aulast=McMahan&rft.aufirst=CJ&rft.au=Slack, JL&rft.au=Mosley, B&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC452992&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">
Colotta F, Re F, Muzio M, et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–5. Bibcode:1993Sci...261..472C. doi:10.1126/science.8332913. PMID 8332913.472-5&rft.date=1993&rft_id=info:pmid/8332913&rft_id=info:doi/10.1126/science.8332913&rft_id=info:bibcode/1993Sci...261..472C&rft.aulast=Colotta&rft.aufirst=F&rft.au=Re, F&rft.au=Muzio, M&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">
Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300.25737-42&rft.date=1997&rft_id=info:doi/10.1074/jbc.272.41.25737&rft_id=info:pmid/9325300&rft.aulast=Torigoe&rft.aufirst=K&rft.au=Ushio, S&rft.au=Okura, T&rft_id=https://doi.org/10.1074%2Fjbc.272.41.25737&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">
Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.29946-54&rft.date=2000&rft_id=info:doi/10.1074/jbc.M004077200&rft_id=info:pmid/10882729&rft.aulast=Born&rft.aufirst=TL&rft.au=Smith, DE&rft.au=Garka, KE&rft_id=https://doi.org/10.1074%2Fjbc.M004077200&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">
Ozkara C, Uzan M, Tanriverdi T, et al. (2006). "Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis". Seizure: The Journal of the British Epilepsy Association. 15 (5): 288–91. doi:10.1016/j.seizure.2006.02.016. PMID 16546408.288-91&rft.date=2006&rft_id=info:doi/10.1016/j.seizure.2006.02.016&rft_id=info:pmid/16546408&rft.aulast=Ozkara&rft.aufirst=C&rft.au=Uzan, M&rft.au=Tanriverdi, T&rft_id=https://doi.org/10.1016%2Fj.seizure.2006.02.016&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115598 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070942 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8898719-5] Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Dec 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.113-22&rft.date=1996-12&rft_id=https://api.semanticscholar.org/CorpusID:53171191#id-name=S2CID&rft_id=info:pmid/8898719&rft_id=info:doi/10.1016/S0165-5728(96)50047-1&rft.aulast=Lovenberg&rft.aufirst=TW&rft.au=Crowe, PD&rft.au=Liu, C&rft.au=Chalmers, DT&rft.au=Liu, XJ&rft.au=Liaw, C&rft.au=Clevenger, W&rft.au=Oltersdorf, T&rft.au=De Souza, EB&rft.au=Maki, RA&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">

[pmid10191101-6] Dale M, Nicklin MJ (Jun 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.177-9&rft.date=1999-06&rft_id=info:doi/10.1006/geno.1999.5767&rft_id=info:pmid/10191101&rft.aulast=Dale&rft.aufirst=M&rft.au=Nicklin, MJ&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">

[pmid11466363-7] Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (Jul 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.1440-6&rft.date=2001-07&rft_id=info:doi/10.4049/jimmunol.167.3.1440&rft_id=info:pmid/11466363&rft.aulast=Debets&rft.aufirst=R&rft.au=Timans, JC&rft.au=Homey, B&rft.au=Zurawski, S&rft.au=Sana, TR&rft.au=Lo, S&rft.au=Wagner, J&rft.au=Edwards, G&rft.au=Clifford, T&rft.au=Menon, S&rft.au=Bazan, JF&rft.au=Kastelein, RA&rft_id=https://doi.org/10.4049%2Fjimmunol.167.3.1440&rfr_id=info:sid/en.wikipedia.org:IL1RL2" class="Z3988">

[entrez-8] "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".

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IL1RL2

References

Further reading