IGF2BP1

IGF2BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KRM
Identifiers
Aliases	IGF2BP1, CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1
External IDs	OMIM: 608288; MGI: 1890357; HomoloGene: 4772; GeneCards: IGF2BP1; OMA:IGF2BP1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,056,145 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	96,005,940 bp
RNA expression pattern
	Top expressed in
	testicle; ; ganglionic eminence; ; gonad; ; ventricular zone; ; stromal cell of endometrium; ; buccal mucosa cell; ; right testis; ; left testis; ; placenta; ; retinal pigment epithelium;
	Top expressed in
	tail of embryo; ; abdominal wall; ; hand; ; epiblast; ; mandibular prominence; ; maxillary prominence; ; primitive streak; ; genital tubercle; ; yolk sac; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	translation regulator activity; mRNA 3'-UTR binding; protein binding; nucleic acid binding; mRNA 5'-UTR binding; mRNA binding; RNA binding;
Cellular component	cytoplasm; CRD-mediated mRNA stability complex; cell projection; filopodium; growth cone; dendritic spine; axon; dendrite; perinuclear region of cytoplasm; cytoplasmic stress granule; nucleus; lamellipodium; nucleoplasm; cytosol; ribonucleoprotein complex;
Biological process	CRD-mediated mRNA stabilization; mRNA transport; negative regulation of translation; pallium cell proliferation in forebrain; neuronal stem cell population maintenance; RNA localization; regulation of translation; regulation of mRNA stability involved in response to stress; regulation of mRNA stability; transport;
	Sources:Amigo / QuickGO
Orthologs
	10642
	140486
	ENSG00000159217
	ENSMUSG00000013415
	Q9NZI8
	O88477
	NM_001160423; NM_006546
	NM_009951
	NP_001153895; NP_006537
	NP_034081; NP_001388383; NP_001388384; NP_001388385; NP_001388386
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.^[5]^[6]^[7]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159217 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013415 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.1262-70&rft.date=1999-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116055#id-name=PMC&rft_id=info:pmid/9891060&rft_id=info:doi/10.1128/MCB.19.2.1262&rft.aulast=Nielsen&rft.aufirst=J&rft.au=Christiansen, J&rft.au=Lykke-Andersen, J&rft.au=Johnsen, AH&rft.au=Wewer, UM&rft.au=Nielsen, FC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116055&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
^ Yaniv K, Yisraeli JK (May 2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene. 287 (1–2): 49–54. doi:10.1016/S0378-1119(01)00866-6. PMID 11992722.1–2&rft.pages=49-54&rft.date=2002-05&rft_id=info:doi/10.1016/S0378-1119(01)00866-6&rft_id=info:pmid/11992722&rft.aulast=Yaniv&rft.aufirst=K&rft.au=Yisraeli, JK&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
^ ^a ^b "Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1".

Perycz M, Urbanska AS, Krawczyk P, Parobczak K, Jaworski J (2011). "Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons". J. Neurosci. 31 (14): 5271–85. doi:10.1523/JNEUROSCI.2387-10.2011. PMC 6622686. PMID 21471362.5271-85&rft.date=2011&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622686#id-name=PMC&rft_id=info:pmid/21471362&rft_id=info:doi/10.1523/JNEUROSCI.2387-10.2011&rft.aulast=Perycz&rft.aufirst=M&rft.au=Urbanska, AS&rft.au=Krawczyk, P&rft.au=Parobczak, K&rft.au=Jaworski, J&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622686&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins". Biol. Cell. 97 (1): 87–96. doi:10.1042/BC20040151. PMID 15601260. S2CID 8767105.87-96&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:8767105#id-name=S2CID&rft_id=info:pmid/15601260&rft_id=info:doi/10.1042/BC20040151&rft.au=Yisraeli JK&rft_id=https://doi.org/10.1042%2FBC20040151&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Prokipcak RD, Herrick DJ, Ross J (1994). "Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA". J. Biol. Chem. 269 (12): 9261–9. doi:10.1016/S0021-9258(17)37102-8. PMID 8132663.9261-9&rft.date=1994&rft_id=info:doi/10.1016/S0021-9258(17)37102-8&rft_id=info:pmid/8132663&rft.aulast=Prokipcak&rft.aufirst=RD&rft.au=Herrick, DJ&rft.au=Ross, J&rft_id=https://doi.org/10.1016%2FS0021-9258%2817%2937102-8&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Doyle GA, Betz NA, Leeds PF, et al. (1999). "The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins". Nucleic Acids Res. 26 (22): 5036–44. doi:10.1093/nar/26.22.5036. PMC 147974. PMID 9801297.5036-44&rft.date=1999&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147974#id-name=PMC&rft_id=info:pmid/9801297&rft_id=info:doi/10.1093/nar/26.22.5036&rft.au=Doyle GA&rft.au=Betz NA&rft.au=Leeds PF&rft.au=Fleisig, AJ&rft.au=Prokipcak, RD&rft.au=Ross, J&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147974&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Runge S, Nielsen FC, Nielsen J, et al. (2000). "H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein". J. Biol. Chem. 275 (38): 29562–9. doi:10.1074/jbc.M001156200. PMID 10875929.29562-9&rft.date=2000&rft_id=info:doi/10.1074/jbc.M001156200&rft_id=info:pmid/10875929&rft.au=Runge S&rft.au=Nielsen FC&rft.au=Nielsen J&rft.au=Lykke-Andersen, J&rft.au=Wewer, UM&rft.au=Christiansen, J&rft_id=https://doi.org/10.1074%2Fjbc.M001156200&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Nielsen FC, Nielsen J, Kristensen MA, et al. (2003). "Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains". J. Cell Sci. 115 (Pt 10): 2087–97. doi:10.1242/jcs.115.10.2087. PMID 11973350.2087-97&rft.date=2003&rft_id=info:doi/10.1242/jcs.115.10.2087&rft_id=info:pmid/11973350&rft.au=Nielsen FC&rft.au=Nielsen J&rft.au=Kristensen MA&rft.au=Koch, G&rft.au=Christiansen, J&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Lemm I, Ross J (2002). "Regulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant". Mol. Cell. Biol. 22 (12): 3959–69. doi:10.1128/MCB.22.12.3959-3969.2002. PMC 133878. PMID 12024010.3959-69&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133878#id-name=PMC&rft_id=info:pmid/12024010&rft_id=info:doi/10.1128/MCB.22.12.3959-3969.2002&rft.aulast=Lemm&rft.aufirst=I&rft.au=Ross, J&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133878&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Ioannidis P, Mahaira L, Papadopoulou A, et al. (2003). "8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas". Int. J. Cancer. 104 (1): 54–9. doi:10.1002/ijc.10794. PMID 12532419. S2CID 45119038.54-9&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:45119038#id-name=S2CID&rft_id=info:pmid/12532419&rft_id=info:doi/10.1002/ijc.10794&rft.au=Ioannidis P&rft.au=Mahaira L&rft.au=Papadopoulou A&rft.au=Teixeira, Manuel R.&rft.au=Heim, Sverre&rft.au=Andersen, Johan A.&rft.au=Evangelou, Evangelos&rft.au=Dafni, Urania&rft.au=Pandis, Nikos&rft_id=https://doi.org/10.1002%2Fijc.10794&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Nielsen J, Adolph SK, Rajpert-De Meyts E, et al. (2003). "Nuclear transit of human zipcode-binding protein IMP1". Biochem. J. 376 (Pt 2): 383–91. doi:10.1042/BJ20030943. PMC 1223771. PMID 12921532.383-91&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223771#id-name=PMC&rft_id=info:pmid/12921532&rft_id=info:doi/10.1042/BJ20030943&rft.au=Nielsen J&rft.au=Adolph SK&rft.au=Rajpert-De Meyts E&rft.au=Lykke-Andersen, Jens&rft.au=Koch, Grete&rft.au=Christiansen, Jan&rft.au=Nielsen, Finn C.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223771&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.au=Ota T&rft.au=Suzuki Y&rft.au=Nishikawa T&rft.au=Otsuki, Tetsuji&rft.au=Sugiyama, Tomoyasu&rft.au=Irie, Ryotaro&rft.au=Wakamatsu, Ai&rft.au=Hayashi, Koji&rft.au=Sato, Hiroyuki&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Gu L, Shigemasa K, Ohama K (2004). "Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer". Int. J. Oncol. 24 (3): 671–8. doi:10.3892/ijo.24.3.671. PMID 14767552.671-8&rft.date=2004&rft_id=info:doi/10.3892/ijo.24.3.671&rft_id=info:pmid/14767552&rft.aulast=Gu&rft.aufirst=L&rft.au=Shigemasa, K&rft.au=Ohama, K&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Hansen TV, Hammer NA, Nielsen J, et al. (2004). "Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice". Mol. Cell. Biol. 24 (10): 4448–64. doi:10.1128/MCB.24.10.4448-4464.2004. PMC 400488. PMID 15121863.4448-64&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400488#id-name=PMC&rft_id=info:pmid/15121863&rft_id=info:doi/10.1128/MCB.24.10.4448-4464.2004&rft.au=Hansen TV&rft.au=Hammer NA&rft.au=Nielsen J&rft.au=Madsen, M.&rft.au=Dalbaeck, C.&rft.au=Wewer, U. M.&rft.au=Christiansen, J.&rft.au=Nielsen, F. C.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400488&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Ioannidis P, Kottaridi C, Dimitriadis E, et al. (2004). "Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors". Cancer Lett. 209 (2): 245–50. doi:10.1016/j.canlet.2003.12.015. PMID 15159028.245-50&rft.date=2004&rft_id=info:doi/10.1016/j.canlet.2003.12.015&rft_id=info:pmid/15159028&rft.au=Ioannidis P&rft.au=Kottaridi C&rft.au=Dimitriadis E&rft.au=Courtis, Nelly&rft.au=Mahaira, Louiza&rft.au=Talieri, Maroulio&rft.au=Giannopoulos, Andreas&rft.au=Iliadis, Kosmas&rft.au=Papaioannou, Dimitrios&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Rackham O, Brown CM (2005). "Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs". EMBO J. 23 (16): 3346–55. doi:10.1038/sj.emboj.7600341. PMC 514514. PMID 15282548.3346-55&rft.date=2005&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514514#id-name=PMC&rft_id=info:pmid/15282548&rft_id=info:doi/10.1038/sj.emboj.7600341&rft.aulast=Rackham&rft.aufirst=O&rft.au=Brown, CM&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514514&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Nielsen J, Kristensen MA, Willemoës M, et al. (2004). "Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability". Nucleic Acids Res. 32 (14): 4368–76. doi:10.1093/nar/gkh754. PMC 514376. PMID 15314207.4368-76&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514376#id-name=PMC&rft_id=info:pmid/15314207&rft_id=info:doi/10.1093/nar/gkh754&rft.au=Nielsen J&rft.au=Kristensen MA&rft.au=Willemoës M&rft.au=Nielsen, FC&rft.au=Christiansen, J&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514376&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.1711-8&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316#id-name=PMC&rft_id=info:pmid/15342556&rft_id=info:doi/10.1101/gr.2435604&rft.au=Suzuki Y&rft.au=Yamashita R&rft.au=Shirota M&rft.au=Sakakibara, Y&rft.au=Chiba, J&rft.au=Mizushima-Sugano, J&rft.au=Nakai, K&rft.au=Sugano, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">
Liao B, Patel M, Hu Y, et al. (2005). "Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells". J. Biol. Chem. 279 (47): 48716–24. doi:10.1074/jbc.M405853200. PMID 15355996.48716-24&rft.date=2005&rft_id=info:doi/10.1074/jbc.M405853200&rft_id=info:pmid/15355996&rft.au=Liao B&rft.au=Patel M&rft.au=Hu Y&rft.au=Charles, S&rft.au=Herrick, DJ&rft.au=Brewer, G&rft_id=https://doi.org/10.1074%2Fjbc.M405853200&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159217 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013415 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9891060-5] Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.1262-70&rft.date=1999-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116055#id-name=PMC&rft_id=info:pmid/9891060&rft_id=info:doi/10.1128/MCB.19.2.1262&rft.aulast=Nielsen&rft.aufirst=J&rft.au=Christiansen, J&rft.au=Lykke-Andersen, J&rft.au=Johnsen, AH&rft.au=Wewer, UM&rft.au=Nielsen, FC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116055&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">

[pmid11992722-6] Yaniv K, Yisraeli JK (May 2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene. 287 (1–2): 49–54. doi:10.1016/S0378-1119(01)00866-6. PMID 11992722.1–2&rft.pages=49-54&rft.date=2002-05&rft_id=info:doi/10.1016/S0378-1119(01)00866-6&rft_id=info:pmid/11992722&rft.aulast=Yaniv&rft.aufirst=K&rft.au=Yisraeli, JK&rfr_id=info:sid/en.wikipedia.org:IGF2BP1" class="Z3988">

[entrez-7] "Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1".

[5]

[6]

[7]

[1]

[2]

[3]

[4]

IGF2BP1

See also

References

Further reading