IFIT1

IFIT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HOU
Identifiers
Aliases	IFIT1, C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561, interferon induced protein with tetratricopeptide repeats 1
External IDs	OMIM: 147690; MGI: 2148249; HomoloGene: 78213; GeneCards: IFIT1; OMA:IFIT1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,618,143 bp
RNA expression pattern
	Top expressed in
	Pons; ; trigeminal ganglion; ; biceps brachii; ; glomerulus; ; metanephric glomerulus; ; palpebral conjunctiva; ; subthalamic nucleus; ; germinal epithelium; ; amniotic fluid; ; parietal pleura;
	Top expressed in
	epithelium of small intestine; ; zygote; ; jejunum; ; secondary oocyte; ; ileum; ; interventricular septum; ; granulocyte; ; primary oocyte; ; duodenum; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	cytoplasm; host cell; cytosol;
Biological process	negative regulation of helicase activity; response to virus; positive regulation of viral genome replication; negative regulation of viral genome replication; negative regulation of defense response to virus by host; cellular response to type I interferon; viral process; intracellular transport of viral protein in host cell; negative regulation of protein binding; type I interferon signaling pathway; innate immune response; regulation of defense response to virus; cellular response to exogenous dsRNA; immune system process; defense response to virus; response to bacterium; cellular response to interferon-beta;
	Sources:Amigo / QuickGO
Orthologs
	3434
	112419
	n/a
	ENSMUSG00000067297
	P09914
	Q3U687
	NM_001548; NM_001270927; NM_001270928; NM_001270929; NM_001270930
	NM_053217; NM_001362130
	NP_001257856; NP_001257857; NP_001257858; NP_001257859; NP_001539
	NP_444447; NP_001349059
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene.^[4]^[5]^[6]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067297 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G (Jul 1992). "The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24". Genomics. 13 (2): 458–60. doi:10.1016/0888-7543(92)90272-T. PMID 1377167.458-60&rft.date=1992-07&rft_id=info:doi/10.1016/0888-7543(92)90272-T&rft_id=info:pmid/1377167&rft.aulast=Lafage&rft.aufirst=M&rft.au=Clauss, I&rft.au=Couez, D&rft.au=Simonetti, J&rft.au=Wathelet, MG&rft.au=Huez, G&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
^ Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. Bibcode:1988FEBSL.231..164W. doi:10.1016/0014-5793(88)80724-5. PMID 3360121. S2CID 22937671.164-71&rft.date=1988-06&rft_id=info:doi/10.1016/0014-5793(88)80724-5&rft_id=https://api.semanticscholar.org/CorpusID:22937671#id-name=S2CID&rft_id=info:pmid/3360121&rft_id=info:bibcode/1988FEBSL.231..164W&rft.aulast=Wathelet&rft.aufirst=MG&rft.au=Clauss, IM&rft.au=Content, J&rft.au=Huez, GA&rft_id=https://doi.org/10.1016%2F0014-5793%2888%2980724-5&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
^ "Entrez Gene: IFIT1 interferon-induced protein with tetratricopeptide repeats 1".

Wathelet MG, Clauss IM, Nols CB, et al. (1988). "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes". Eur. J. Biochem. 169 (2): 313–21. doi:10.1111/j.1432-1033.1987.tb13614.x. PMID 3121313.313-21&rft.date=1988&rft_id=info:doi/10.1111/j.1432-1033.1987.tb13614.x&rft_id=info:pmid/3121313&rft.aulast=Wathelet&rft.aufirst=MG&rft.au=Clauss, IM&rft.au=Nols, CB&rft_id=https://doi.org/10.1111%2Fj.1432-1033.1987.tb13614.x&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat. Cell Mol. Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763. S2CID 42406993.415-26&rft.date=1988&rft_id=https://api.semanticscholar.org/CorpusID:42406993#id-name=S2CID&rft_id=info:pmid/3175763&rft_id=info:doi/10.1007/BF01534709&rft.aulast=Wathelet&rft.aufirst=MG&rft.au=Szpirer, J&rft.au=Nols, CB&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Kusari J, Szabo P, Grzeschik KH, Sen GC (1987). "Chromosomal localization of the interferon-inducible human gene encoding mRNA 561". J. Interferon Res. 7 (1): 53–9. doi:10.1089/jir.1987.7.53. PMID 3585080.53-9&rft.date=1987&rft_id=info:doi/10.1089/jir.1987.7.53&rft_id=info:pmid/3585080&rft.aulast=Kusari&rft.aufirst=J&rft.au=Szabo, P&rft.au=Grzeschik, KH&rft.au=Sen, GC&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Wathelet M, Moutschen S, Defilippi P, et al. (1986). "Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons". Eur. J. Biochem. 155 (1): 11–7. doi:10.1111/j.1432-1033.1986.tb09452.x. PMID 3753936.11-7&rft.date=1986&rft_id=info:doi/10.1111/j.1432-1033.1986.tb09452.x&rft_id=info:pmid/3753936&rft.aulast=Wathelet&rft.aufirst=M&rft.au=Moutschen, S&rft.au=Defilippi, P&rft_id=https://doi.org/10.1111%2Fj.1432-1033.1986.tb09452.x&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Chebath J, Merlin G, Metz R, et al. (1983). "Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA". Nucleic Acids Res. 11 (5): 1213–26. doi:10.1093/nar/11.5.1213. PMC 325791. PMID 6186990.1213-26&rft.date=1983&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC325791#id-name=PMC&rft_id=info:pmid/6186990&rft_id=info:doi/10.1093/nar/11.5.1213&rft.aulast=Chebath&rft.aufirst=J&rft.au=Merlin, G&rft.au=Metz, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC325791&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Rebouillat D, Marié I, Hovanessian AG (1998). "Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase". Eur. J. Biochem. 257 (2): 319–30. doi:10.1046/j.1432-1327.1998.2570319.x. PMID 9826176.319-30&rft.date=1998&rft_id=info:doi/10.1046/j.1432-1327.1998.2570319.x&rft_id=info:pmid/9826176&rft.aulast=Rebouillat&rft.aufirst=D&rft.au=Marié, I&rft.au=Hovanessian, AG&rft_id=https://doi.org/10.1046%2Fj.1432-1327.1998.2570319.x&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Guo J, Sen GC (2000). "Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus". J. Virol. 74 (4): 1892–9. doi:10.1128/JVI.74.4.1892-1899.2000. PMC 111667. PMID 10644362.1892-9&rft.date=2000&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC111667#id-name=PMC&rft_id=info:pmid/10644362&rft_id=info:doi/10.1128/JVI.74.4.1892-1899.2000&rft.aulast=Guo&rft.aufirst=J&rft.au=Sen, GC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC111667&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Guo J, Peters KL, Sen GC (2000). "Induction of the human protein P56 by interferon, double-stranded RNA, or virus infection". Virology. 267 (2): 209–19. doi:10.1006/viro.1999.0135. PMID 10662616.209-19&rft.date=2000&rft_id=info:doi/10.1006/viro.1999.0135&rft_id=info:pmid/10662616&rft.aulast=Guo&rft.aufirst=J&rft.au=Peters, KL&rft.au=Sen, GC&rft_id=https://doi.org/10.1006%2Fviro.1999.0135&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Guo J, Hui DJ, Merrick WC, Sen GC (2001). "A new pathway of translational regulation mediated by eukaryotic initiation factor 3". EMBO J. 19 (24): 6891–9. doi:10.1093/emboj/19.24.6891. PMC 305884. PMID 11118224.6891-9&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305884#id-name=PMC&rft_id=info:pmid/11118224&rft_id=info:doi/10.1093/emboj/19.24.6891&rft.aulast=Guo&rft.aufirst=J&rft.au=Hui, DJ&rft.au=Merrick, WC&rft.au=Sen, GC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305884&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Patzwahl R, Meier V, Ramadori G, Mihm S (2001). "Enhanced Expression of Interferon-Regulated Genes in the Liver of Patients with Chronic Hepatitis C Virus Infection: Detection by Suppression-Subtractive Hybridization". J. Virol. 75 (3): 1332–8. doi:10.1128/JVI.75.3.1332-1338.2001. PMC 114039. PMID 11152506.1332-8&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114039#id-name=PMC&rft_id=info:pmid/11152506&rft_id=info:doi/10.1128/JVI.75.3.1332-1338.2001&rft.aulast=Patzwahl&rft.aufirst=R&rft.au=Meier, V&rft.au=Ramadori, G&rft.au=Mihm, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114039&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, et al. (2003). "[Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus]". Bioorg. Khim. 29 (2): 175–80. doi:10.1023/a:1023260415910. PMID 12708317. S2CID 34300356.175-80&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:34300356#id-name=S2CID&rft_id=info:pmid/12708317&rft_id=info:doi/10.1023/a:1023260415910&rft.aulast=Gavrilov&rft.aufirst=BG&rft.au=Monastyrskaia, GS&rft.au=Velikodvorskaia, TV&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan, K&rft.au=Hao, T&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.55-65&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129#id-name=PMC&rft_id=info:pmid/16344560&rft_id=info:doi/10.1101/gr.4039406&rft.aulast=Kimura&rft.aufirst=K&rft.au=Wakamatsu, A&rft.au=Suzuki, Y&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">
Terenzi F, Hui DJ, Merrick WC, Sen GC (2006). "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56". J. Biol. Chem. 281 (45): 34064–71. doi:10.1074/jbc.M605771200. PMID 16973618.34064-71&rft.date=2006&rft_id=info:doi/10.1074/jbc.M605771200&rft_id=info:pmid/16973618&rft.aulast=Terenzi&rft.aufirst=F&rft.au=Hui, DJ&rft.au=Merrick, WC&rft.au=Sen, GC&rft_id=https://doi.org/10.1074%2Fjbc.M605771200&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000067297 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1377167-4] Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G (Jul 1992). "The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24". Genomics. 13 (2): 458–60. doi:10.1016/0888-7543(92)90272-T. PMID 1377167.458-60&rft.date=1992-07&rft_id=info:doi/10.1016/0888-7543(92)90272-T&rft_id=info:pmid/1377167&rft.aulast=Lafage&rft.aufirst=M&rft.au=Clauss, I&rft.au=Couez, D&rft.au=Simonetti, J&rft.au=Wathelet, MG&rft.au=Huez, G&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">

[pmid3360121-5] Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. Bibcode:1988FEBSL.231..164W. doi:10.1016/0014-5793(88)80724-5. PMID 3360121. S2CID 22937671.164-71&rft.date=1988-06&rft_id=info:doi/10.1016/0014-5793(88)80724-5&rft_id=https://api.semanticscholar.org/CorpusID:22937671#id-name=S2CID&rft_id=info:pmid/3360121&rft_id=info:bibcode/1988FEBSL.231..164W&rft.aulast=Wathelet&rft.aufirst=MG&rft.au=Clauss, IM&rft.au=Content, J&rft.au=Huez, GA&rft_id=https://doi.org/10.1016%2F0014-5793%2888%2980724-5&rfr_id=info:sid/en.wikipedia.org:IFIT1" class="Z3988">

[entrez-6] "Entrez Gene: IFIT1 interferon-induced protein with tetratricopeptide repeats 1".

[4]

[5]

[6]

[1]

[2]

[3]

IFIT1

References

Further reading