The enzyme homoaconitate hydratase (EC 4.2.1.36) catalyzes the chemical reaction
| homoaconitate hydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Homoaconitate hydratase homodimer, Methanocaldococcus jannaschii | |||||||||
| Identifiers | |||||||||
| EC no. | 4.2.1.36 | ||||||||
| CAS no. | 9030-68-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (Z)-but-1-ene-1,2,4-tricarboxylate H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]. Other names in common use include homoaconitase, cis-homoaconitase, HACN, Lys4, LysF, and 2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase (incorrect). This enzyme participates in lysine biosynthesis.
References
edit- Strassman M, Ceci LN (1966). "Enzymatic formation of cis-homoaconitic acid, an intermediate in lysine biosynthesis in yeast". J. Biol. Chem. 241 (22): 5401–7. PMID 5954805.5401-7&rft.date=1966&rft_id=info:pmid/5954805&rft.aulast=Strassman&rft.aufirst=M&rft.au=Ceci, LN&rfr_id=info:sid/en.wikipedia.org:Homoaconitate hydratase" class="Z3988">
- Jia Y, Tomita T, Yamauchi K, Nishiyama M, Palmer DR (2006). "Kinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilus". Biochem. J. 396 (3): 479–85. doi:10.1042/BJ20051711. PMC 1482822. PMID 16524361.479-85&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482822#id-name=PMC&rft_id=info:pmid/16524361&rft_id=info:doi/10.1042/BJ20051711&rft.aulast=Jia&rft.aufirst=Y&rft.au=Tomita, T&rft.au=Yamauchi, K&rft.au=Nishiyama, M&rft.au=Palmer, DR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482822&rfr_id=info:sid/en.wikipedia.org:Homoaconitate hydratase" class="Z3988">
- Zabriskie TM, Jackson MD (2000). "Lysine biosynthesis and metabolism in fungi". Nat. Prod. Rep. 17 (1): 85–97. doi:10.1039/a801345d. PMID 10714900.85-97&rft.date=2000&rft_id=info:doi/10.1039/a801345d&rft_id=info:pmid/10714900&rft.aulast=Zabriskie&rft.aufirst=TM&rft.au=Jackson, MD&rfr_id=info:sid/en.wikipedia.org:Homoaconitate hydratase" class="Z3988">
