HTR3C

5-hydroxytryptamine receptor 3C is a protein that in humans is encoded by the HTR3C gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor.

HTR3C
Identifiers
Aliases	HTR3C, 5-hydroxytryptamine receptor 3C
External IDs	OMIM: 610121; HomoloGene: 50847; GeneCards: HTR3C; OMA:HTR3C - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q27.1 Start 184,053,047 bp End 184,060,673 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right lung mucosa of transverse colon upper lobe of left lung duodenum right lobe of thyroid gland left lobe of thyroid gland gallbladder myometrium skin of abdomen n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding extracellular ligand-gated ion channel activity serotonin-gated cation-selective channel activity ion channel activity transmembrane signaling receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane neuron projection synapse Biological process ion transport signal transduction ion transmembrane transport serotonin receptor signaling pathway chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 170572 n/a Ensembl ENSG00000178084 n/a UniProt Q8WXA8 n/a RefSeq (mRNA) NM_130770 n/a RefSeq (protein) NP_570126 n/a Location (UCSC) Chr 3: 184.05 – 184.06 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Karnovsky AM, Gotow LF, McKinley DD, et al. (2003). "A cluster of novel serotonin receptor 3-like genes on human chromosome 3". Gene. 319: 137–48. doi:10.1016/S0378-1119(03)00803-5. PMID 14597179.137-48&rft.date=2003&rft_id=info:doi/10.1016/S0378-1119(03)00803-5&rft_id=info:pmid/14597179&rft.aulast=Karnovsky&rft.aufirst=AM&rft.au=Gotow, LF&rft.au=McKinley, DD&rfr_id=info:sid/en.wikipedia.org:HTR3C" class="Z3988">
• Fasching PA, Kollmannsberger B, Strissel PL, et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy". J. Cancer Res. Clin. Oncol. 134 (10): 1079–86. doi:10.1007/s00432-008-0387-1. PMID 18389280. S2CID 7504731.1079-86&rft.date=2008&rft_id=https://api.semanticscholar.org/CorpusID:7504731#id-name=S2CID&rft_id=info:pmid/18389280&rft_id=info:doi/10.1007/s00432-008-0387-1&rft.aulast=Fasching&rft.aufirst=PA&rft.au=Kollmannsberger, B&rft.au=Strissel, PL&rfr_id=info:sid/en.wikipedia.org:HTR3C" class="Z3988">
• Ward MB, Kotasek D, McKinnon RA (2008). "Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy". Pharmacogenomics. 9 (8): 1027–33. doi:10.2217/14622416.9.8.1027. PMID 18681779.1027-33&rft.date=2008&rft_id=info:doi/10.2217/14622416.9.8.1027&rft_id=info:pmid/18681779&rft.aulast=Ward&rft.aufirst=MB&rft.au=Kotasek, D&rft.au=McKinnon, RA&rfr_id=info:sid/en.wikipedia.org:HTR3C" class="Z3988">

External links

• HTR3C protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)