Wikipedia

Hippocalcin-like protein 1

(Redirected from HPCAL1)

Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.[5][6][7]

HPCAL1
Identifiers
AliasesHPCAL1, BDR1, HLP2, VILIP-3, hippocalcin like 1
External IDsOMIM: 600207; MGI: 1855689; HomoloGene: 37586; GeneCards: HPCAL1; OMA:HPCAL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3241

53602

Ensembl

ENSG00000115756

ENSMUSG00000071379

UniProt

P37235

P62748

RefSeq (mRNA)

NM_001258357
NM_001258358
NM_001258359
NM_002149
NM_134421

NM_016677
NM_001361645

RefSeq (protein)

NP_001245286
NP_001245287
NP_001245288
NP_002140
NP_602293

NP_057886
NP_001348574

Location (UCSC)Chr 2: 10.3 – 10.43 MbChr 12: 17.69 – 17.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the neuron-specific calcium-binding proteins family found in the retina and brain.[8] It is highly similar to human hippocalcin protein, and nearly identical to rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation, and may be of relevance to neuronal signaling in the central nervous system. There are two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites.[7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115756 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071379 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T (Aug 1994). "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene". Biochim Biophys Acta. 1222 (3): 515–8. doi:10.1016/0167-4889(94)90062-0. PMID 8038222.515-8&rft.date=1994-08&rft_id=info:doi/10.1016/0167-4889(94)90062-0&rft_id=info:pmid/8038222&rft.aulast=Kobayashi&rft.aufirst=M&rft.au=Takamatsu, K&rft.au=Fujishiro, M&rft.au=Saitoh, S&rft.au=Noguchi, T&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  6. ^ Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M (Apr 2004). "Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2 -dependent manner". J Biol Chem. 279 (15): 15142–52. doi:10.1074/jbc.M312766200. PMID 14739275.15142-52&rft.date=2004-04&rft_id=info:doi/10.1074/jbc.M312766200&rft_id=info:pmid/14739275&rft.aulast=Oikawa&rft.aufirst=K&rft.au=Kimura, S&rft.au=Aoki, N&rft.au=Atsuta, Y&rft.au=Takiyama, Y&rft.au=Nagato, T&rft.au=Yanai, M&rft.au=Kobayashi, H&rft.au=Sato, K&rft.au=Sasajima, T&rft.au=Tateno, M&rft_id=https://doi.org/10.1074%2Fjbc.M312766200&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  7. ^ a b "Entrez Gene: HPCAL1 hippocalcin-like 1".
  8. ^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2 Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.182-193&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887812#id-name=PMC&rft_id=info:pmid/17311005&rft_id=info:doi/10.1038/nrn2093&rft.au=Burgoyne RD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887812&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">

Further reading

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  • Hidaka H, Okazaki K (1993). "Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system". Neurosci. Res. 16 (2): 73–7. doi:10.1016/0168-0102(93)90074-Z. PMID 8387172. S2CID 4210072.73-7&rft.date=1993&rft_id=https://api.semanticscholar.org/CorpusID:4210072#id-name=S2CID&rft_id=info:pmid/8387172&rft_id=info:doi/10.1016/0168-0102(93)90074-Z&rft.aulast=Hidaka&rft.aufirst=H&rft.au=Okazaki, K&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.107-13&rft.date=1996&rft_id=info:doi/10.1006/abio.1996.0138&rft_id=info:pmid/8619474&rft.au=Andersson B&rft.au=Wentland MA&rft.au=Ricafrente JY&rft.au=Liu, W&rft.au=Gibbs, RA&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.353-8&rft.date=1997&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146#id-name=PMC&rft_id=info:pmid/9110174&rft_id=info:doi/10.1101/gr.7.4.353&rft.au=Yu W&rft.au=Andersson B&rft.au=Worley KC&rft.au=Muzny, DM&rft.au=Ding, Y&rft.au=Liu, W&rft.au=Ricafrente, JY&rft.au=Wentland, MA&rft.au=Lennon, G&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  • Spilker C, Richter K, Smalla KH, et al. (2000). "The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association". Neuroscience. 96 (1): 121–9. doi:10.1016/S0306-4522(99)00536-9. PMID 10683417. S2CID 22063490.121-9&rft.date=2000&rft_id=https://api.semanticscholar.org/CorpusID:22063490#id-name=S2CID&rft_id=info:pmid/10683417&rft_id=info:doi/10.1016/S0306-4522(99)00536-9&rft.au=Spilker C&rft.au=Richter K&rft.au=Smalla KH&rft.au=Manahan-Vaughan, D&rft.au=Gundelfinger, ED&rft.au=Braunewell, KH&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  • Bernstein HG, Baumann B, Danos P, et al. (2000). "Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain". J. Neurocytol. 28 (8): 655–62. doi:10.1023/A:1007056731551. PMID 10851344. S2CID 7944931.655-62&rft.date=2000&rft_id=https://api.semanticscholar.org/CorpusID:7944931#id-name=S2CID&rft_id=info:pmid/10851344&rft_id=info:doi/10.1023/A:1007056731551&rft.au=Bernstein HG&rft.au=Baumann B&rft.au=Danos P&rft.au=Diekmann, Silvia&rft.au=Bogerts, Bernhard&rft.au=Gundelfinger, Eckart D.&rft.au=Braunewell, Karl-Heinz&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.1788-95&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948#id-name=PMC&rft_id=info:pmid/11076863&rft_id=info:doi/10.1101/gr.143000&rft.aulast=Hartley&rft.aufirst=JL&rft.au=Temple, GF&rft.au=Brasch, MA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  • Braunewell K, Riederer P, Spilker C, et al. (2001). "Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients". Dementia and Geriatric Cognitive Disorders. 12 (2): 110–6. doi:10.1159/000051244. PMID 11173883. S2CID 21446098.110-6&rft.date=2001&rft_id=https://api.semanticscholar.org/CorpusID:21446098#id-name=S2CID&rft_id=info:pmid/11173883&rft_id=info:doi/10.1159/000051244&rft.au=Braunewell K&rft.au=Riederer P&rft.au=Spilker C&rft.au=Gundelfinger, E.D.&rft.au=Bogerts, B.&rft.au=Bernstein, H.-G.&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  • Ivings L, Pennington SR, Jenkins R, et al. (2002). "Identification of Ca2 -dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". Biochem. J. 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599. PMC 1222513. PMID 11964161.599-608&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222513#id-name=PMC&rft_id=info:pmid/11964161&rft_id=info:doi/10.1042/0264-6021:3630599&rft.au=Ivings L&rft.au=Pennington SR&rft.au=Jenkins R&rft.au=Weiss, Jamie L.&rft.au=Burgoyne, Robert D.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222513&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  • Spilker C, Gundelfinger ED, Braunewell KH (2002). "Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function". Biochim. Biophys. Acta. 1600 (1–2): 118–27. doi:10.1016/s1570-9639(02)00452-1. PMID 12445467.1–2&rft.pages=118-27&rft.date=2002&rft_id=info:doi/10.1016/s1570-9639(02)00452-1&rft_id=info:pmid/12445467&rft.aulast=Spilker&rft.aufirst=C&rft.au=Gundelfinger, ED&rft.au=Braunewell, KH&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.au=Strausberg RL&rft.au=Feingold EA&rft.au=Grouse LH&rft.au=Derge, JG&rft.au=Klausner, RD&rft.au=Collins, FS&rft.au=Wagner, L&rft.au=Shenmen, CM&rft.au=Schuler, GD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:Hippocalcin-like protein 1" class="Z3988">
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