Wikipedia

HOMER2

(Redirected from HOMER2 (gene))

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.[5][6][7]

HOMER2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHOMER2, ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2
External IDsOMIM: 604799; MGI: 1347354; HomoloGene: 3560; GeneCards: HOMER2; OMA:HOMER2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9455

26557

Ensembl

ENSG00000103942

ENSMUSG00000025813

UniProt

Q9NSB8

Q9QWW1

RefSeq (mRNA)

NM_004839
NM_199330
NM_199331
NM_199332

NM_001164086
NM_001164087
NM_011983
NM_177029

RefSeq (protein)

NP_004830
NP_955362

NP_001157558
NP_001157559
NP_036113

Location (UCSC)Chr 15: 82.84 – 82.99 MbChr 7: 81.25 – 81.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.[7]

Interactions

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HOMER2 has been shown to interact with RYR1.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103942 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025813 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.717-26&rft.date=1998-12&rft_id=info:doi/10.1016/S0896-6273(00)80589-9&rft_id=info:pmid/9808459&rft.aulast=Tu&rft.aufirst=JC&rft.au=Xiao, B&rft.au=Yuan, JP&rft.au=Lanahan, AA&rft.au=Leoffert, K&rft.au=Li, M&rft.au=Linden, DJ&rft.au=Worley, PF&rft_id=https://doi.org/10.1016%2FS0896-6273%2800%2980589-9&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  6. ^ Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Dec 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.707-16&rft.date=1998-12&rft_id=info:doi/10.1016/S0896-6273(00)80588-7&rft_id=info:pmid/9808458&rft.aulast=Xiao&rft.aufirst=B&rft.au=Tu, JC&rft.au=Petralia, RS&rft.au=Yuan, JP&rft.au=Doan, A&rft.au=Breder, CD&rft.au=Ruggiero, A&rft.au=Lanahan, AA&rft.au=Wenthold, RJ&rft.au=Worley, PF&rft_id=https://doi.org/10.1016%2FS0896-6273%2800%2980588-7&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  7. ^ a b "Entrez Gene: HOMER2 homer homolog 2 (Drosophila)".
  8. ^ Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. 277 (47). United States: 44722–30. doi:10.1074/jbc.M207675200. ISSN 0021-9258. PMID 12223488.44722-30&rft.date=2002-11&rft.issn=0021-9258&rft_id=info:pmid/12223488&rft_id=info:doi/10.1074/jbc.M207675200&rft.aulast=Feng&rft.aufirst=Wei&rft.au=Tu Jiancheng&rft.au=Yang Tianzhong&rft.au=Vernon Patty Shih&rft.au=Allen Paul D&rft.au=Worley Paul F&rft.au=Pessah Isaac N&rft_id=https://doi.org/10.1074%2Fjbc.M207675200&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">

Further reading

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  • Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". J. Mol. Biol. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.1185-200&rft.date=2000&rft_id=info:doi/10.1006/jmbi.1999.3436&rft_id=info:pmid/10653696&rft.aulast=Soloviev&rft.aufirst=MM&rft.au=Ciruela, F&rft.au=Chan, WY&rft.au=McIlhinney, RA&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  • Feng W, Tu J, Yang T, et al. (2003). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.44722-30&rft.date=2003&rft_id=info:doi/10.1074/jbc.M207675200&rft_id=info:pmid/12223488&rft.aulast=Feng&rft.aufirst=W&rft.au=Tu, J&rft.au=Yang, T&rft_id=https://doi.org/10.1074%2Fjbc.M207675200&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  • Kim JT, Park SH, Kim SK, et al. (2003). "Potential role of Homer-2a on cutaneous vascular anomaly". J. Korean Med. Sci. 17 (5): 636–40. doi:10.3346/jkms.2002.17.5.636. PMC 3054924. PMID 12378015.636-40&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054924#id-name=PMC&rft_id=info:pmid/12378015&rft_id=info:doi/10.3346/jkms.2002.17.5.636&rft.aulast=Kim&rft.aufirst=JT&rft.au=Park, SH&rft.au=Kim, SK&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054924&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  • Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T (2003). "Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons". Mol. Cell. Neurosci. 22 (2): 188–201. doi:10.1016/S1044-7431(03)00037-X. PMID 12676529. S2CID 38323844.188-201&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:38323844#id-name=S2CID&rft_id=info:pmid/12676529&rft_id=info:doi/10.1016/S1044-7431(03)50037-X&rft.aulast=Shiraishi&rft.aufirst=Y&rft.au=Mizutani, A&rft.au=Mikoshiba, K&rft.au=Furuichi, T&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  • Rong R, Ahn JY, Huang H, et al. (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310. S2CID 807407.1153-61&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:807407#id-name=S2CID&rft_id=info:pmid/14528310&rft_id=info:doi/10.1038/nn1134&rft.aulast=Rong&rft.aufirst=R&rft.au=Ahn, JY&rft.au=Huang, H&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  • Ishibashi T, Ogawa S, Hashiguchi Y, et al. (2005). "A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems". J. Biochem. 137 (5): 617–23. doi:10.1093/jb/mvi074. PMID 18634415.617-23&rft.date=2005&rft_id=info:doi/10.1093/jb/mvi074&rft_id=info:pmid/18634415&rft.aulast=Ishibashi&rft.aufirst=T&rft.au=Ogawa, S&rft.au=Hashiguchi, Y&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan, K&rft.au=Hao, T&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">
  • Dahl JP, Kampman KM, Oslin DW, et al. (2006). "Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population". Psychiatr. Genet. 15 (4): 277–83. doi:10.1097/00041444-200512000-00010. PMID 16314758. S2CID 24128233.277-83&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:24128233#id-name=S2CID&rft_id=info:pmid/16314758&rft_id=info:doi/10.1097/00041444-200512000-00010&rft.aulast=Dahl&rft.aufirst=JP&rft.au=Kampman, KM&rft.au=Oslin, DW&rfr_id=info:sid/en.wikipedia.org:HOMER2" class="Z3988">


 

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