HLA-DR6 (DR6) is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.
Serology
edit| DRB1* | DR13 | DR6 | DR14 | Sample |
| allele | % | % | % | size (N) |
| 1301 | 81 | 14 | 1 | 3788 |
| 1302 | 74 | 17 | 2 | 3081 |
| 1303 | 69 | 10 | 2 | 948[2] |
| 1304 | 87 | 127 | ||
| 1305 | 54 | 12 | 305[3] | |
| 1306 | 78 | 9 | ||
| 1307 | >50 | 1 | ||
| 1308 | 45 | 55 | 9 | |
| 1310 | >75 | 5 | ||
| DRB1* | DR14 | DR6 | DR13 | N |
| 1401 | 74 | 14 | 3 | 1942 |
| 1402 | 61 | 13 | 9 | 204 |
| 1403 | 72 | 12 | 2 | 37 |
| 1404 | 79 | 8 | 80[4] | |
| 1405 | 86 | 10 | 58 | |
| 1406 | 37 | 15 | 22 | 117 |
| 1407 | 90 | 10 | ||
| 1408 | 25 | 4[5] | ||
| 1410 | >75 | 4 |
DR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7.
Disease associations
editDR13 and DR14 share a common association to myasthenia gravis.[6]
Allele groups
editHLA-DRB1*13 and HLA-DRB1*14 encode serotypes of DR6.
References
edit- ^ derived from IMGT/HLA
- ^ DR12 - 3%, DR11 - 3% DR5-2%
- ^ DR12 - 6%, DR11 - 7% DR5-4%
- ^ DR1404 - 3%
- ^ DR4 - 25%
- ^ Shinomiya N, Nomura Y, Segawa M (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan". Clin Immunol. 110 (2): 154–8. doi:10.1016/j.clim.2003.10.004. PMID 15003812.