HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.
Serology
edit| DRB1* | DR15 | DR2 | DR16 | Sample |
| allele | % | % | % | size (N) |
| 15:01 | 76 | 23 | 6428 | |
| 15:02 | 77 | 16 | 676 | |
| 15:03 | 81 | 13 | 286 | |
| 15:04 | >50 | 1 | ||
| 15:05 | >25 | 2 | ||
| 15:07 | >50 | 1 | ||
| . | ||||
| DR16 | DR2 | DR15 | N | |
| 16:01 | 41 | 29 | 19 | 703 |
| 16:02 | 47 | 30 | 16 | 239 |
| 16:04 | >50 | 1 |
Disease associations
editDR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis,[2] narcolepsy, tuberculoid leprosy[3] (multi-drug-resistant tuberculosis or leprosy),[4] ulcerative colitis (Japanese),[5] primary biliary cirrhosis and autoimmune hepatitis.[6] DR2 is also found in all patients that test positive for anti-Asn-RNA-synthetase and chronic interstitial lung disease.[7]
Genetic linkage
editDR2 is linked to the HLA-DR51.
References
edit- ^ derived from IMGT/HLA
- ^ Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and multiple sclerosis: A common gene, dominantly expressed". Hum Immunol. 3 (1): 13–29. doi:10.1016/0198-8859(81)90040-9. PMID 7275697.13-29&rft.date=1981&rft_id=info:doi/10.1016/0198-8859(81)90040-9&rft_id=info:pmid/7275697&rft.aulast=Stewart&rft.aufirst=G&rft.au=McLeod, J&rft.au=Basten, A&rft.au=Bashir, H&rfr_id=info:sid/en.wikipedia.org:HLA-DR2" class="Z3988">
- ^ van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J (1980). "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker". J Infect Dis. 141 (6): 693–701. doi:10.1093/infdis/141.6.693. PMID 6156220.693-701&rft.date=1980&rft_id=info:doi/10.1093/infdis/141.6.693&rft_id=info:pmid/6156220&rft.aulast=van Eden&rft.aufirst=W&rft.au=de Vries, R&rft.au=Mehra, N&rft.au=Vaidya, M&rft.au=D'Amaro, J&rft.au=van Rood, J&rfr_id=info:sid/en.wikipedia.org:HLA-DR2" class="Z3988">
- ^ Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK (2007). "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens. 69 (Suppl 1): 228–30. doi:10.1111/j.1399-0039.2006.77311.x. PMID 17445206.228-30&rft.date=2007&rft_id=info:doi/10.1111/j.1399-0039.2006.77311.x&rft_id=info:pmid/17445206&rft.aulast=Singh&rft.aufirst=M&rft.au=Balamurugan, A&rft.au=Katoch, K&rft.au=Sharma, SK&rft.au=Mehra, NK&rfr_id=info:sid/en.wikipedia.org:HLA-DR2" class="Z3988">
- ^ Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S (1982). "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis". Gastroenterology. 82 (3): 413–8. doi:10.1016/S0016-5085(82)80387-9. PMID 6947923.413-8&rft.date=1982&rft_id=info:doi/10.1016/S0016-5085(82)80387-9&rft_id=info:pmid/6947923&rft.aulast=Asakura&rft.aufirst=H&rft.au=Tsuchiya, M&rft.au=Aiso, S&rft.au=Watanabe, M&rft.au=Kobayashi, K&rft.au=Hibi, T&rft.au=Ando, K&rft.au=Takata, H&rft.au=Sekiguchi, S&rft_id=https://doi.org/10.1016%2FS0016-5085%2882%2980387-9&rfr_id=info:sid/en.wikipedia.org:HLA-DR2" class="Z3988">
- ^ Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis". Digestion. 26 (4): 213–7. doi:10.1159/000198892. PMID 6409699.213-7&rft.date=1983&rft_id=info:doi/10.1159/000198892&rft_id=info:pmid/6409699&rft.aulast=Miyamori&rft.aufirst=H&rft.au=Kato, Y&rft.au=Kobayashi, K&rft.au=Hattori, N&rfr_id=info:sid/en.wikipedia.org:HLA-DR2" class="Z3988">
- ^ Hirakata M, Suwa A, Takada T, et al. (2007). "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum. 56 (4): 1295–303. doi:10.1002/art.22506. PMID 17393393.1295-303&rft.date=2007&rft_id=info:doi/10.1002/art.22506&rft_id=info:pmid/17393393&rft.aulast=Hirakata&rft.aufirst=M&rft.au=Suwa, A&rft.au=Takada, T&rft_id=https://doi.org/10.1002%2Fart.22506&rfr_id=info:sid/en.wikipedia.org:HLA-DR2" class="Z3988">