In enzymology, a glycerol dehydratase (EC 4.2.1.30) catalyzes the chemical reaction
| glycerol dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.30 | ||||||||
| CAS no. | 9077-68-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- glycerol 3-hydroxypropanal H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is glycerol hydro-lyase (3-hydroxypropanol-forming). Other names in common use include glycerol dehydrase, and glycerol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobalamin.
Structural studies
editAs of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1IWP and 1MMF.
References
edit- Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149 (2): 413–9. doi:10.1128/JB.149.2.413-419.1982. PMC 216523. PMID 7035429.413-9&rft.date=1982&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC216523#id-name=PMC&rft_id=info:pmid/7035429&rft_id=info:doi/10.1128/JB.149.2.413-419.1982&rft.aulast=Forage&rft.aufirst=RG&rft.au=Foster, MA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC216523&rfr_id=info:sid/en.wikipedia.org:Glycerol dehydratase" class="Z3988">
- Schneider Z, Larsen EG, Jacobson G, Johnson BC, Pawelkiewicz J (1970). "Purification and properties of glycerol dehydrase". J. Biol. Chem. 245 (13): 3388–96. doi:10.1016/S0021-9258(18)63008-X. PMID 4989992.3388-96&rft.date=1970&rft_id=info:doi/10.1016/S0021-9258(18)63008-X&rft_id=info:pmid/4989992&rft.aulast=Schneider&rft.aufirst=Z&rft.au=Larsen, EG&rft.au=Jacobson, G&rft.au=Johnson, BC&rft.au=Pawelkiewicz, J&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2963008-X&rfr_id=info:sid/en.wikipedia.org:Glycerol dehydratase" class="Z3988">
- Schneider Z, Pawelkiewicz J (1966). "The properties of glycerol dehydratase isolated from Aerobacter aerogenes, and the properties of the apoenzyme subunits". Acta Biochim. Pol. 13 (4): 311–28. PMID 5962440.311-28&rft.date=1966&rft_id=info:pmid/5962440&rft.aulast=Schneider&rft.aufirst=Z&rft.au=Pawelkiewicz, J&rfr_id=info:sid/en.wikipedia.org:Glycerol dehydratase" class="Z3988">
- SMILEY KL, SOBOLOV M (1962). "A cobamide-requiring glycerol dehydrase from an acrolein-forming Lactobacillus". Arch. Biochem. Biophys. 97 (3): 538–43. doi:10.1016/0003-9861(62)90118-2. PMID 14039344.538-43&rft.date=1962&rft_id=info:doi/10.1016/0003-9861(62)90118-2&rft_id=info:pmid/14039344&rft.aulast=SMILEY&rft.aufirst=KL&rft.au=SOBOLOV, M&rfr_id=info:sid/en.wikipedia.org:Glycerol dehydratase" class="Z3988">
