In enzymology, a glucuronate reductase (EC 1.1.1.19) is an enzyme that catalyzes the chemical reaction
| L-glucuronate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.19 | ||||||||
| CAS no. | 9028-29-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- L-gulonate NADP D-glucuronate NADPH H
Thus, the two substrates of this enzyme are L-gulonate and NADP , whereas its 3 products are D-glucuronate, NADPH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is L-gulonate:NADP 6-oxidoreductase. Other names in common use include aldehyde reductase, L-hexonate:NADP dehydrogenase, TPN-L-gulonate dehydrogenase, aldehyde reductase II, NADP-L-gulonate dehydrogenase, D-glucuronate dehydrogenase, D-glucuronate reductase, and L-glucuronate reductase (incorrect). This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.
References
edit- Sivak A, Hoffmann-Ostenhof O (1961). "Enzymes of mesoinositol catabolism in the yeast Schwanniomyces occidentalis". Biochim. Biophys. Acta. 53 (2): 426–8. doi:10.1016/0006-3002(61)90462-0. PMID 13913518.426-8&rft.date=1961&rft_id=info:doi/10.1016/0006-3002(61)90462-0&rft_id=info:pmid/13913518&rft.aulast=Sivak&rft.aufirst=A&rft.au=Hoffmann-Ostenhof, O&rfr_id=info:sid/en.wikipedia.org:Glucuronate reductase" class="Z3988">
- Jakoby, W. B. (Ed.), Enzymatic Basis of Detoxication, vol. 1, Academic Press, New York, 1980, p. 249–260.
- York JL, Grollman AP, Bublitz C (1961). "TPN-L-gluonate dehydrogenase". Biochim. Biophys. Acta. 47 (2): 298–306. doi:10.1016/0006-3002(61)90290-6. PMID 13787380.298-306&rft.date=1961&rft_id=info:doi/10.1016/0006-3002(61)90290-6&rft_id=info:pmid/13787380&rft.aulast=York&rft.aufirst=JL&rft.au=Grollman, AP&rft.au=Bublitz, C&rfr_id=info:sid/en.wikipedia.org:Glucuronate reductase" class="Z3988">
