GPRC5D

GPRC5D
Identifiers
Aliases	GPRC5D, G protein-coupled receptor, class C, group 5, member D, G protein-coupled receptor class C group 5 member D
External IDs	OMIM: 607437; MGI: 1935037; HomoloGene: 10250; GeneCards: GPRC5D; OMA:GPRC5D - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	12,952,170 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	135,095,281 bp
RNA expression pattern
	Top expressed in
	testicle; ; upper lobe of left lung; ; hair follicle; ; mucosa of transverse colon; ; rectum; ; right lung; ; minor salivary glands; ; bone marrow cells; ; mucosa of esophagus; ; islet of Langerhans;
	Top expressed in
	lip; ; blastocyst; ; embryo; ; hair follicle; ; skin of abdomen; ; embryo; ; skin of back; ; dermis; ; skin of external ear; ; sexually immature organism;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; protein kinase activator activity;
Cellular component	integral component of membrane; plasma membrane; membrane; receptor complex; intracellular membrane-bounded organelle; extracellular exosome;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	55507
	93746
	ENSG00000111291
	ENSMUSG00000030205
	Q9NZD1
	Q9JIL6
	NM_018654
	NM_001205396; NM_053118
	NP_061124
	NP_001192325; NP_444348
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.^[5] GPRC5D is a class C orphan Gprotein-coupled receptor predominantly expressed in multiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells.^[6]^[7]^[8]

Structure

Structural analysis of the complex between GPRC5D and Talquetamab, a bispecific antibody for the treatment of multiple myeloma, has revealed that GPRC5D exists as a dimer. GPRC5D forms a symmetric dimer via TM4 and TM4/TM5 interactions. The study further demonstrated that only one Talquetamab molecule can bind to the dimeric form of GPRC5D. Talquetamab Fab recognizes ECLs and TM3/5/7 of one GPRC5D protomer via six CDRs. ^[9]

GPRC5D complexed with Talquetamab Fab (PDB: 9IMA)

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111291 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030205 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: GPRC5D G protein-coupled receptor, family C, group 5, member D".
^ "The RAIG family member, GPRC5D, is associated with hard-keratinized structures". J. Invest. Dermatol.
^ Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, et al. (March 2019). "GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells". Science Translational Medicine. 11 (485). doi:10.1126/scitranslmed.aau7746. PMC 7508042. PMID 30918115.
^ Verkleij CP, Broekmans ME, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, et al. (April 2021). "Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma". Blood Advances. 5 (8): 2196–2215. doi:10.1182/bloodadvances.2020003805. PMC 8095149. PMID 33890981.
^ Jeong J, Park J, Young Mo G, Shin J, Cho Y (August 2024). "Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma". Journal of Molecular Biology. 436 (20): 168748. doi:10.1016/j.jmb.2024.168748. PMID 39181182.

GPRC5D

Contents

Structure

Function

See also

References

Further reading