GBF1

GBF1
Identifiers
Aliases	GBF1, ARF1GEF, golgi brefeldin A resistant guanine nucleotide exchange factor 1, CMT2GG
External IDs	OMIM: 603698; MGI: 1861607; HomoloGene: 37897; GeneCards: GBF1; OMA:GBF1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	102,382,899 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,274,949 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; ventricular zone; ; anterior pituitary; ; sural nerve; ; stromal cell of endometrium; ; ganglionic eminence; ; right lobe of thyroid gland; ; apex of heart; ; mucosa of transverse colon; ; right hemisphere of cerebellum;
	Top expressed in
	neural layer of retina; ; zygote; ; tail of embryo; ; lacrimal gland; ; secondary oocyte; ; genital tubercle; ; muscle of thigh; ; seminiferous tubule; ; molar; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3,5-bisphosphate binding; protein binding; guanyl-nucleotide exchange factor activity; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding;
Cellular component	lipid droplet; Golgi membrane; trans-Golgi network; cell leading edge; peroxisome; cytoplasm; endoplasmic reticulum lumen; Golgi stack; mitochondrion; cytosol; Golgi apparatus; membrane; cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment;
Biological process	Golgi disassembly; protein localization to endoplasmic reticulum tubular network; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; protein transport; Golgi organization; viral process; regulation of mitotic cell cycle; endoplasmic reticulum-Golgi intermediate compartment organization; post-Golgi vesicle-mediated transport; establishment of monopolar cell polarity; protein localization to endoplasmic reticulum exit site; regulation of protein localization to cell surface; endoplasmic reticulum to Golgi vesicle-mediated transport; cell activation involved in immune response; protein localization to Golgi apparatus; neutrophil chemotaxis; reactive oxygen species biosynthetic process; retrograde transport, endosome to Golgi; Golgi to endosome transport; regulation of ARF protein signal transduction; COPI coating of Golgi vesicle; transport; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	8729
	107338
	ENSG00000107862
	ENSMUSG00000025224
	Q92538
	n/a
NM_001199378; NM_001199379; NM_004193; NM_001377137; NM_001377138;
	NM_001377139; NM_001377140; NM_001377141; NM_001391922; NM_001391923; NM_001391924; NM_001391925; NM_001391926; NM_001391927; NM_001391928; NM_001391929; NM_001391930; NM_001391931
	NM_178930
	NP_001186307; NP_001186308; NP_004184
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107862 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025224 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mansour SJ, Herbrick JA, Scherer SW, Melancon P (Jan 1999). "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24". Genomics. 54 (2): 323–7. doi:10.1006/geno.1998.5563. PMID 9828135.323-7&rft.date=1999-01&rft_id=info:doi/10.1006/geno.1998.5563&rft_id=info:pmid/9828135&rft.aulast=Mansour&rft.aufirst=SJ&rft.au=Herbrick, JA&rft.au=Scherer, SW&rft.au=Melancon, P&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
^ "Entrez Gene: GBF1 golgi-specific brefeldin A resistance factor 1".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.99-106&rft.date=2003&rft_id=info:doi/10.1093/dnares/9.3.99&rft_id=info:pmid/12168954&rft.aulast=Nakajima&rft.aufirst=D&rft.au=Okazaki, N&rft.au=Yamakawa, H&rft_id=https://doi.org/10.1093%2Fdnares%2F9.3.99&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.321-9, 341-54&rft.date=1997&rft_id=info:doi/10.1093/dnares/3.5.321&rft_id=info:pmid/9039502&rft.aulast=Nagase&rft.aufirst=T&rft.au=Seki, N&rft.au=Ishikawa, K&rft_id=https://doi.org/10.1093%2Fdnares%2F3.5.321&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Claude A, Zhao BP, Kuziemsky CE, et al. (1999). "GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5". J. Cell Biol. 146 (1): 71–84. doi:10.1083/jcb.146.1.71. PMC 2199737. PMID 10402461.71-84&rft.date=1999&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199737#id-name=PMC&rft_id=info:pmid/10402461&rft_id=info:doi/10.1083/jcb.146.1.71&rft.aulast=Claude&rft.aufirst=A&rft.au=Zhao, BP&rft.au=Kuziemsky, CE&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199737&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Kawamoto K, Yoshida Y, Tamaki H, et al. (2003). "GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat". Traffic. 3 (7): 483–95. doi:10.1034/j.1600-0854.2002.30705.x. PMID 12047556. S2CID 45336536.483-95&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:45336536#id-name=S2CID&rft_id=info:pmid/12047556&rft_id=info:doi/10.1034/j.1600-0854.2002.30705.x&rft.aulast=Kawamoto&rft.aufirst=K&rft.au=Yoshida, Y&rft.au=Tamaki, H&rft_id=https://doi.org/10.1034%2Fj.1600-0854.2002.30705.x&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
García-Mata R, Sztul E (2003). "The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor". EMBO Rep. 4 (3): 320–5. doi:10.1038/sj.embor.embor762. PMC 1315890. PMID 12634853.320-5&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315890#id-name=PMC&rft_id=info:pmid/12634853&rft_id=info:doi/10.1038/sj.embor.embor762&rft.aulast=García-Mata&rft.aufirst=R&rft.au=Sztul, E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315890&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Claude A, Zhao BP, Melançon P (2003). "Characterization of alternatively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines regions important for activity". Biochem. Biophys. Res. Commun. 303 (1): 160–9. doi:10.1016/S0006-291X(03)00316-4. hdl:10533/173991. PMID 12646181.160-9&rft.date=2003&rft_id=info:hdl/10533/173991&rft_id=info:pmid/12646181&rft_id=info:doi/10.1016/S0006-291X(03)00316-4&rft.aulast=Claude&rft.aufirst=A&rft.au=Zhao, BP&rft.au=Melançon, P&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.375-81&rft.date=2004&rft_id=info:pmid/15164054&rft_id=info:doi/10.1038/nature02462&rft_id=info:bibcode/2004Natur.429..375D&rft.aulast=Deloukas&rft.aufirst=P&rft.au=Earthrowl, ME&rft.au=Grafham, DV&rft_id=https://doi.org/10.1038%2Fnature02462&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.12130-5&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446#id-name=PMC&rft_id=info:pmid/15302935&rft_id=info:doi/10.1073/pnas.0404720101&rft_id=info:bibcode/2004PNAS..10112130B&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Jedrychowski, M&rft.au=Schwartz, D&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.1436-50&rft.date=2004&rft_id=info:doi/10.1016/j.cub.2004.07.051&rft_id=https://api.semanticscholar.org/CorpusID:2371325#id-name=S2CID&rft_id=info:pmid/15324660&rft_id=info:bibcode/2004CBio...14.1436J&rft.aulast=Jin&rft.aufirst=J&rft.au=Smith, FD&rft.au=Stark, C&rft_id=https://doi.org/10.1016%2Fj.cub.2004.07.051&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.1093-101&rft.date=2005&rft_id=info:doi/10.1074/mcp.M400085-MCP200&rft_id=info:pmid/15345747&rft.aulast=Ballif&rft.aufirst=BA&rft.au=Villén, J&rft.au=Beausoleil, SA&rft_id=https://doi.org/10.1074%2Fmcp.M400085-MCP200&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Niu TK, Pfeifer AC, Lippincott-Schwartz J, Jackson CL (2005). "Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi". Mol. Biol. Cell. 16 (3): 1213–22. doi:10.1091/mbc.E04-07-0599. PMC 551486. PMID 15616190.1213-22&rft.date=2005&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551486#id-name=PMC&rft_id=info:pmid/15616190&rft_id=info:doi/10.1091/mbc.E04-07-0599&rft.aulast=Niu&rft.aufirst=TK&rft.au=Pfeifer, AC&rft.au=Lippincott-Schwartz, J&rft.au=Jackson, CL&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551486&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Szul T, Garcia-Mata R, Brandon E, et al. (2005). "Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1". Traffic. 6 (5): 374–85. doi:10.1111/j.1600-0854.2005.00282.x. PMID 15813748. S2CID 23845874.374-85&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:23845874#id-name=S2CID&rft_id=info:pmid/15813748&rft_id=info:doi/10.1111/j.1600-0854.2005.00282.x&rft.aulast=Szul&rft.aufirst=T&rft.au=Garcia-Mata, R&rft.au=Brandon, E&rft_id=https://doi.org/10.1111%2Fj.1600-0854.2005.00282.x&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Roy SK, Hu J, Meng Q, et al. (2006). "Development of monoclonal antibodies against GBF1 and their use in studying its functions". J. Interferon Cytokine Res. 25 (11): 666–73. doi:10.1089/jir.2005.25.666. PMID 16318580.666-73&rft.date=2006&rft_id=info:doi/10.1089/jir.2005.25.666&rft_id=info:pmid/16318580&rft.aulast=Roy&rft.aufirst=SK&rft.au=Hu, J&rft.au=Meng, Q&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.5391-6&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365#id-name=PMC&rft_id=info:pmid/16565220&rft_id=info:doi/10.1073/pnas.0507066103&rft_id=info:bibcode/2006PNAS..103.5391N&rft.aulast=Nousiainen&rft.aufirst=M&rft.au=Silljé, HH&rft.au=Sauer, G&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Zhao X, Claude A, Chun J, et al. (2006). "GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic". J. Cell Sci. 119 (Pt 18): 3743–53. doi:10.1242/jcs.03173. PMID 16926190.3743-53&rft.date=2006&rft_id=info:doi/10.1242/jcs.03173&rft_id=info:pmid/16926190&rft.aulast=Zhao&rft.aufirst=X&rft.au=Claude, A&rft.au=Chun, J&rft_id=https://doi.org/10.1242%2Fjcs.03173&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">
Belov GA, Altan-Bonnet N, Kovtunovych G, et al. (2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA". J. Virol. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMC 1797456. PMID 17079330.558-67&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797456#id-name=PMC&rft_id=info:pmid/17079330&rft_id=info:doi/10.1128/JVI.01820-06&rft.aulast=Belov&rft.aufirst=GA&rft.au=Altan-Bonnet, N&rft.au=Kovtunovych, G&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797456&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107862 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025224 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9828135-5] Mansour SJ, Herbrick JA, Scherer SW, Melancon P (Jan 1999). "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24". Genomics. 54 (2): 323–7. doi:10.1006/geno.1998.5563. PMID 9828135.323-7&rft.date=1999-01&rft_id=info:doi/10.1006/geno.1998.5563&rft_id=info:pmid/9828135&rft.aulast=Mansour&rft.aufirst=SJ&rft.au=Herbrick, JA&rft.au=Scherer, SW&rft.au=Melancon, P&rfr_id=info:sid/en.wikipedia.org:GBF1" class="Z3988">

[entrez-6] "Entrez Gene: GBF1 golgi-specific brefeldin A resistance factor 1".

[5]

[6]

[1]

[2]

[3]

[4]

GBF1

References

Further reading