Polypeptide N-acetylgalactosaminyltransferase 3 is an enzyme that in humans is encoded by the GALNT3 gene .[ 5] [ 6] [ 7]
This gene encodes UDP-GalNAc transferase 3, a member of the polypeptide GalNAc transferase (GalNAc-T) family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O -linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O -glycosylationhomologous to other family members; however, the enzymes have different substrate specificities.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000115339 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026994 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Bennett EP, Weghuis DO, Merkx G, van Kessel AG, Eiberg H, Clausen H (Jul 1998). "Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family" . Glycobiology . 8 (6): 547– 55. doi :10.1093/glycob/8.6.547 PMID 9592121 . 547- 55&rft.date=1998-07&rft_id=info:doi/10.1093/glycob/8.6.547&rft_id=info:pmid/9592121&rft.aulast=Bennett&rft.aufirst=EP&rft.au=Weghuis, DO&rft.au=Merkx, G&rft.au=van Kessel, AG&rft.au=Eiberg, H&rft.au=Clausen, H&rft_id=https://doi.org/10.1093%2Fglycob%2F8.6.547&rfr_id=info:sid/en.wikipedia.org:GALNT3" class="Z3988">^ Topaz O, Shurman DL, Bergman R, Indelman M, Ratajczak P, Mizrachi M, Khamaysi Z, Behar D, Petronius D, Friedman V, Zelikovic I, Raimer S, Metzker A, Richard G, Sprecher E (May 2004). "Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis" . Nat Genet . 36 (6): 579– 81. doi :10.1038/ng1358 PMID 15133511 . 579- 81&rft.date=2004-05&rft_id=info:doi/10.1038/ng1358&rft_id=info:pmid/15133511&rft.aulast=Topaz&rft.aufirst=O&rft.au=Shurman, DL&rft.au=Bergman, R&rft.au=Indelman, M&rft.au=Ratajczak, P&rft.au=Mizrachi, M&rft.au=Khamaysi, Z&rft.au=Behar, D&rft.au=Petronius, D&rft.au=Friedman, V&rft.au=Zelikovic, I&rft.au=Raimer, S&rft.au=Metzker, A&rft.au=Richard, G&rft.au=Sprecher, E&rft_id=https://doi.org/10.1038%2Fng1358&rfr_id=info:sid/en.wikipedia.org:GALNT3" class="Z3988">^ a b "Entrez Gene: GALNT3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)" .
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PMID 9394011 . 45- 60&rft.date=1998&rft_id=info:doi/10.1242/jcs.111.1.45&rft_id=info:pmid/9394011&rft.au=Röttger S&rft.au=White J&rft.au=Wandall HH&rft.au=Olivo, JC&rft.au=Stark, A&rft.au=Bennett, EP&rft.au=Whitehouse, C&rft.au=Berger, EG&rft.au=Clausen, H&rfr_id=info:sid/en.wikipedia.org:GALNT3" class="Z3988">Mandel U, Hassan H, Therkildsen MH, et al. (1999). "Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family" . 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