Fcabs are antibodies fragments engineered from the constant region of an antibody (Fc).[1] In naturally occurring antibodies (such as IgGs), the antigen-binding sites are located at the variable regions (Fab).
Overview
editFcabs can be expressed as soluble proteins or they can be engineered back into a full IgG. This type of antibodies are therefore able to recognise two different antigens, one at their Fab region and a second one at the Fc region, hence the name of bispecific antibodies. This antibody fragment is part of the modular antibody technology of F-star Biotechnology Ltd.[citation needed]
See also
editReferences
edit- ^ Wozniak-Knopp G, Bartl S, Bauer A, Mostageer M, Woisetschläger M, Antes B, Ettl K, Kainer M, Weberhofer G, Wiederkum S, Himmler G, Mudde GC, Rüker F (2010). "Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties". Protein Eng Des. 23 (4): 289–297. doi:10.1093/protein/gzq005. PMID 20150180.289-297&rft.date=2010&rft_id=info:doi/10.1093/protein/gzq005&rft_id=info:pmid/20150180&rft.aulast=Wozniak-Knopp&rft.aufirst=G&rft.au=Bartl, S&rft.au=Bauer, A&rft.au=Mostageer, M&rft.au=Woisetschläger, M&rft.au=Antes, B&rft.au=Ettl, K&rft.au=Kainer, M&rft.au=Weberhofer, G&rft.au=Wiederkum, S&rft.au=Himmler, G&rft.au=Mudde, GC&rft.au=Rüker, F&rft_id=https://doi.org/10.1093%2Fprotein%2Fgzq005&rfr_id=info:sid/en.wikipedia.org:Fcab" class="Z3988">