Frizzled-5

Frizzled-5 (Fz-5) is a protein that in humans is encoded by the FZD5 gene.

FZD5
Identifiers
Aliases	FZD5, C2orf31, HFZ5, frizzled class receptor 5
External IDs	OMIM: 601723; MGI: 108571; HomoloGene: 2590; GeneCards: FZD5; OMA:FZD5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.3 Start 207,762,598 bp End 207,769,906 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C2|1 32.74 cM Start 64,769,717 bp End 64,776,910 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of sigmoid colon lower lobe of lung mucosa of ileum duodenum mucosa of transverse colon palpebral conjunctiva kidney tubule visceral pleura tibia Top expressed in median eminence hair follicle epithelium of small intestine epithelium of stomach ciliary body left colon arcuate nucleus Paneth cell calvaria ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function amyloid-beta binding signal transducer activity Wnt-protein binding protein binding protein kinase binding ubiquitin protein ligase binding transmembrane signaling receptor activity Wnt-activated receptor activity G protein-coupled receptor activity Cellular component clathrin-coated endocytic vesicle membrane Golgi apparatus early endosome membrane membrane bicellular tight junction Golgi membrane plasma membrane cell surface early endosome perinuclear region of cytoplasm integral component of membrane Biological process G protein-coupled receptor signaling pathway T cell differentiation in thymus chorionic trophoblast cell differentiation positive regulation of protein targeting to mitochondrion positive regulation of JUN kinase activity apoptotic process involved in morphogenesis regulation of chorionic trophoblast cell proliferation regulation of bicellular tight junction assembly regulation of canonical Wnt signaling pathway cellular response to molecule of bacterial origin positive regulation of interferon-gamma production embryonic axis specification labyrinthine layer blood vessel development cell maturation Wnt signaling pathway embryonic camera-type eye development multicellular organism development cell surface receptor signaling pathway vasculature development regulation of autophagy of mitochondrion branching involved in labyrinthine layer morphogenesis embryonic camera-type eye morphogenesis post-embryonic camera-type eye development positive regulation of T cell cytokine production angiogenesis neuron differentiation Wnt signaling pathway involved in dorsal/ventral axis specification canonical Wnt signaling pathway synapse assembly syncytiotrophoblast cell differentiation involved in labyrinthine layer development anterior/posterior axis specification, embryo Spemann organizer formation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation signal transduction Wnt signaling pathway, calcium modulating pathway Wnt signaling pathway, planar cell polarity pathway beta-catenin destruction complex disassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7855 14367 Ensembl ENSG00000163251 ENSMUSG00000045005 UniProt Q13467 Q9EQD0 RefSeq (mRNA) NM_030804 NM_003468 NM_001033193 NM_001042659 NM_022721 RefSeq (protein) NP_003459 NP_001036124 NP_073558 Location (UCSC) Chr 2: 207.76 – 207.77 Mb Chr 1: 64.77 – 64.78 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Fz-5 is believed to be the receptor for the Wnt5A ligand.

Further reading

• He X, Saint-Jeannet JP, Wang Y, et al. (1997). "A member of the Frizzled protein family mediating axis induction by Wnt-5A". Science. 275 (5306): 1652–4. doi:10.1126/science.275.5306.1652. PMID 9054360. S2CID 36777692.1652-4&rft.date=1997&rft_id=https://api.semanticscholar.org/CorpusID:36777692#id-name=S2CID&rft_id=info:pmid/9054360&rft_id=info:doi/10.1126/science.275.5306.1652&rft.aulast=He&rft.aufirst=X&rft.au=Saint-Jeannet, JP&rft.au=Wang, Y&rft_id=https://zenodo.org/record/1231094&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.6770-5&rft.date=1997&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21233#id-name=PMC&rft_id=info:pmid/9192640&rft_id=info:doi/10.1073/pnas.94.13.6770&rft_id=info:bibcode/1997PNAS...94.6770F&rft.aulast=Finch&rft.aufirst=PW&rft.au=He, X&rft.au=Kelley, MJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21233&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.10164-9&rft.date=1998&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21479#id-name=PMC&rft_id=info:pmid/9707618&rft_id=info:doi/10.1073/pnas.95.17.10164&rft_id=info:bibcode/1998PNAS...9510164T&rft.aulast=Tanaka&rft.aufirst=S&rft.au=Akiyoshi, T&rft.au=Mori, M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21479&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Tamai K, Semenov M, Kato Y, et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–5. Bibcode:2000Natur.407..530T. doi:10.1038/35035117. PMID 11029007. S2CID 4400159.530-5&rft.date=2000&rft_id=info:doi/10.1038/35035117&rft_id=https://api.semanticscholar.org/CorpusID:4400159#id-name=S2CID&rft_id=info:pmid/11029007&rft_id=info:bibcode/2000Natur.407..530T&rft.aulast=Tamai&rft.aufirst=K&rft.au=Semenov, M&rft.au=Kato, Y&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.422-35&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072#id-name=PMC&rft_id=info:pmid/11230166&rft_id=info:doi/10.1101/gr.GR1547R&rft.aulast=Wiemann&rft.aufirst=S&rft.au=Weil, B&rft.au=Wellenreuther, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064.771-8&rft.date=2001&rft_id=info:doi/10.1006/bbrc.2001.5430&rft_id=info:pmid/11520064&rft.aulast=Yao&rft.aufirst=R&rft.au=Maeda, T&rft.au=Takada, S&rft.au=Noda, T&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Weidler C, Schaumburger J, Miller LE, et al. (2004). "Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation". J. Rheumatol. 31 (9): 1874–5. PMID 15338479.1874-5&rft.date=2004&rft_id=info:pmid/15338479&rft.aulast=Weidler&rft.aufirst=C&rft.au=Schaumburger, J&rft.au=Miller, LE&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.81-90&rft.date=2004&rft_id=https://api.semanticscholar.org/CorpusID:32817238#id-name=S2CID&rft_id=info:pmid/15370539&rft_id=info:doi/10.1080/13816810490514270&rft.aulast=Omoto&rft.aufirst=S&rft.au=Hayashi, T&rft.au=Kitahara, K&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). "Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein". Biochem. Biophys. Res. Commun. 328 (2): 533–9. doi:10.1016/j.bbrc.2005.01.009. PMID 15694380.533-9&rft.date=2005&rft_id=info:doi/10.1016/j.bbrc.2005.01.009&rft_id=info:pmid/15694380&rft.aulast=Holmen&rft.aufirst=SL&rft.au=Robertson, SA&rft.au=Zylstra, CR&rft.au=Williams, BO&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.724-31&rft.date=2005&rft_id=info:pmid/15815621&rft_id=info:doi/10.1038/nature03466&rft_id=info:bibcode/2005Natur.434..724H&rft.aulast=Hillier&rft.aufirst=LW&rft.au=Graves, TA&rft.au=Fulton, RS&rft_id=https://doi.org/10.1038%2Fnature03466&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Blumenthal A, Ehlers S, Lauber J, et al. (2006). "The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation". Blood. 108 (3): 965–73. doi:10.1182/blood-2005-12-5046. PMID 16601243.965-73&rft.date=2006&rft_id=info:doi/10.1182/blood-2005-12-5046&rft_id=info:pmid/16601243&rft.aulast=Blumenthal&rft.aufirst=A&rft.au=Ehlers, S&rft.au=Lauber, J&rft_id=https://doi.org/10.1182%2Fblood-2005-12-5046&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin". Dev. Cell. 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161.213-23&rft.date=2006&rft_id=info:doi/10.1016/j.devcel.2006.07.003&rft_id=info:pmid/16890161&rft.aulast=Yamamoto&rft.aufirst=H&rft.au=Komekado, H&rft.au=Kikuchi, A&rft_id=https://doi.org/10.1016%2Fj.devcel.2006.07.003&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">
• Katoh Y, Katoh M (2007). "Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer". Int. J. Oncol. 30 (3): 751–5. doi:10.3892/ijo.30.3.751. PMID 17273778.751-5&rft.date=2007&rft_id=info:doi/10.3892/ijo.30.3.751&rft_id=info:pmid/17273778&rft.aulast=Katoh&rft.aufirst=Y&rft.au=Katoh, M&rft_id=https://doi.org/10.3892%2Fijo.30.3.751&rfr_id=info:sid/en.wikipedia.org:Frizzled-5" class="Z3988">

External links

• "Frizzled Receptors: FZD₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-06-25. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.