Frizzled-3

(Redirected from FZD3)

Frizzled-3 (Fz-3) is a protein that in humans is encoded by the FZD3 gene.[5][6][7]

FZD3
Identifiers
AliasesFZD3, Fz-3, frizzled class receptor 3
External IDsOMIM: 606143; MGI: 108476; HomoloGene: 23004; GeneCards: FZD3; OMA:FZD3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017412
NM_145866

NM_021458

RefSeq (protein)

NP_059108
NP_665873

NP_067433

Location (UCSC)Chr 8: 28.49 – 28.57 MbChr 14: 65.43 – 65.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[7]

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[8][9]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104290Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007989Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun. 271 (1): 8–14. doi:10.1006/bbrc.2000.2578. PMID 10777673.8-14&rft.date=2000-06&rft_id=info:doi/10.1006/bbrc.2000.2578&rft_id=info:pmid/10777673&rft.aulast=Kirikoshi&rft.aufirst=H&rft.au=Koike, J&rft.au=Sagara, N&rft.au=Saitoh, T&rft.au=Tokuhara, M&rft.au=Tanaka, K&rft.au=Sekihara, H&rft.au=Hirai, M&rft.au=Katoh, M&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  6. ^ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun. 273 (1): 27–34. doi:10.1006/bbrc.2000.2882. PMID 10873558.27-34&rft.date=2000-07&rft_id=info:doi/10.1006/bbrc.2000.2882&rft_id=info:pmid/10873558&rft.aulast=Sala&rft.aufirst=CF&rft.au=Formenti, E&rft.au=Terstappen, GC&rft.au=Caricasole, A&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  7. ^ a b "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)".
  8. ^ Hua ZL, Smallwood PM, Nathans J (Dec 2013). "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons". eLife. 2: e01482. doi:10.7554/eLife.01482. PMC 3865743. PMID 24347548.
  9. ^ Hua ZL, Jeon S, Caterina MJ, Nathans J (Jul 2014). "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system". Proc Natl Acad Sci U S A. 111 (29): E3005-14. Bibcode:2014PNAS..111E3005H. doi:10.1073/pnas.1406399111. PMC 4115534. PMID 24799694.

Further reading

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  • Katoh M (2002). "GIPC gene family (Review)". Int. J. Mol. Med. 9 (6): 585–9. doi:10.3892/ijmm.9.6.585. PMID 12011974.585-9&rft.date=2002&rft_id=info:doi/10.3892/ijmm.9.6.585&rft_id=info:pmid/12011974&rft.au=Katoh M&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  • Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.6770-5&rft.date=1997&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21233#id-name=PMC&rft_id=info:pmid/9192640&rft_id=info:doi/10.1073/pnas.94.13.6770&rft_id=info:bibcode/1997PNAS...94.6770F&rft.aulast=Finch&rft.aufirst=PW&rft.au=He, X&rft.au=Kelley, MJ&rft.au=Uren, A&rft.au=Schaudies, RP&rft.au=Popescu, NC&rft.au=Rudikoff, S&rft.au=Aaronson, SA&rft.au=Varmus, HE&rft.au=Rubin, JS&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21233&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  • Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells". Biochem. Biophys. Res. Commun. 263 (2): 384–8. doi:10.1006/bbrc.1999.1344. PMID 10491302.384-8&rft.date=1999&rft_id=info:doi/10.1006/bbrc.1999.1344&rft_id=info:pmid/10491302&rft.aulast=Wright&rft.aufirst=M&rft.au=Aikawa, M&rft.au=Szeto, W&rft.au=Papkoff, J&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  • Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). "Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes". J. Invest. Dermatol. 116 (6): 940–6. doi:10.1046/j.1523-1747.2001.01336.x. PMID 11407985.940-6&rft.date=2001&rft_id=info:doi/10.1046/j.1523-1747.2001.01336.x&rft_id=info:pmid/11407985&rft.aulast=Hung&rft.aufirst=BS&rft.au=Wang, XQ&rft.au=Cam, GR&rft.au=Rothnagel, JA&rft_id=https://doi.org/10.1046%2Fj.1523-1747.2001.01336.x&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  • Katsu T, Ujike H, Nakano T, Tanaka Y, Nomura A, Nakata K, Takaki M, Sakai A, Uchida N, Imamura T, Kuroda S (2004). "The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia". Neurosci. Lett. 353 (1): 53–6. doi:10.1016/j.neulet.2003.09.017. PMID 14642436. S2CID 109984.53-6&rft.date=2004&rft_id=https://api.semanticscholar.org/CorpusID:109984#id-name=S2CID&rft_id=info:pmid/14642436&rft_id=info:doi/10.1016/j.neulet.2003.09.017&rft.aulast=Katsu&rft.aufirst=T&rft.au=Ujike, H&rft.au=Nakano, T&rft.au=Tanaka, Y&rft.au=Nomura, A&rft.au=Nakata, K&rft.au=Takaki, M&rft.au=Sakai, A&rft.au=Uchida, N&rft.au=Imamura, T&rft.au=Kuroda, S&rft_id=http://ousar.lib.okayama-u.ac.jp/8380&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  • Zhang Y, Yu X, Yuan Y, Ling Y, Ruan Y, Si T, Lu T, Wu S, Gong X, Zhu Z, Yang J, Wang F, Zhang D (2005). "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. doi:10.1002/ajmg.b.30076. PMID 15274031. S2CID 33599450.16-9&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:33599450#id-name=S2CID&rft_id=info:pmid/15274031&rft_id=info:doi/10.1002/ajmg.b.30076&rft.aulast=Zhang&rft.aufirst=Y&rft.au=Yu, X&rft.au=Yuan, Y&rft.au=Ling, Y&rft.au=Ruan, Y&rft.au=Si, T&rft.au=Lu, T&rft.au=Wu, S&rft.au=Gong, X&rft.au=Zhu, Z&rft.au=Yang, J&rft.au=Wang, F&rft.au=Zhang, D&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.2819-24&rft.date=2005&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2286551#id-name=PMC&rft_id=info:pmid/15340161&rft_id=info:doi/10.1110/ps.04682504&rft.aulast=Zhang&rft.aufirst=Z&rft.au=Henzel, WJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2286551&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  • Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.81-90&rft.date=2004&rft_id=https://api.semanticscholar.org/CorpusID:32817238#id-name=S2CID&rft_id=info:pmid/15370539&rft_id=info:doi/10.1080/13816810490514270&rft.aulast=Omoto&rft.aufirst=S&rft.au=Hayashi, T&rft.au=Kitahara, K&rft.au=Takeuchi, T&rft.au=Ueoka, Y&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
  • Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H (2005). "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders". Journal of Neural Transmission. 112 (2): 303–7. doi:10.1007/s00702-004-0264-2. PMID 15657645. S2CID 22324795.303-7&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:22324795#id-name=S2CID&rft_id=info:pmid/15657645&rft_id=info:doi/10.1007/s00702-004-0264-2&rft.aulast=Hashimoto&rft.aufirst=R&rft.au=Suzuki, T&rft.au=Iwata, N&rft.au=Yamanouchi, Y&rft.au=Kitajima, T&rft.au=Kosuga, A&rft.au=Tatsumi, M&rft.au=Ozaki, N&rft.au=Kamijima, K&rft.au=Kunugi, H&rfr_id=info:sid/en.wikipedia.org:Frizzled-3" class="Z3988">
edit
  • "Frizzled Receptors: FZD3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-09-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.