Frizzled-10

Frizzled-10 (Fz-10) is a protein that in humans is encoded by the FZD10 gene. Fz-10 has also been designated as CD350 (cluster of differentiation 350).

FZD10
Identifiers
Aliases	FZD10, CD350, FZ-10, Fz10, FzE7, hFz10, frizzled class receptor 10
External IDs	OMIM: 606147; MGI: 2136761; HomoloGene: 21411; GeneCards: FZD10; OMA:FZD10 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.33 Start 130,162,459 bp End 130,165,740 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G1.3 Start 128,677,908 bp End 128,681,157 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium cartilage tissue epithelium of esophagus mucosa of pharynx gonad synovial joint human penis oral cavity testicle skin of hip Top expressed in hand tail of embryo genital tubercle lip ventral posteroinferior nucleus internal capsule foot maxillary prominence hair urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein binding transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-protein binding Wnt-activated receptor activity Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane cell surface nucleoplasm Biological process cellular response to retinoic acid G protein-coupled receptor signaling pathway regulation of actin cytoskeleton organization non-canonical Wnt signaling pathway via JNK cascade positive regulation of JUN kinase activity Wnt signaling pathway multicellular organism development positive regulation of GTPase activity cell surface receptor signaling pathway negative regulation of GTPase activity neuron differentiation signal transduction canonical Wnt signaling pathway non-canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11211 93897 Ensembl ENSG00000111432 ENSMUSG00000081683 UniProt Q9ULW2 Q8BKG4 RefSeq (mRNA) NM_007197 NM_175284 RefSeq (protein) NP_009128 NP_780493 Location (UCSC) Chr 12: 130.16 – 130.17 Mb Chr 5: 128.68 – 128.68 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.

Further reading

• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (Jun 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.6770-5&rft.date=1997-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21233#id-name=PMC&rft_id=info:pmid/9192640&rft_id=info:doi/10.1073/pnas.94.13.6770&rft_id=info:bibcode/1997PNAS...94.6770F&rft.aulast=Finch&rft.aufirst=PW&rft.au=He, X&rft.au=Kelley, MJ&rft.au=Uren, A&rft.au=Schaudies, RP&rft.au=Popescu, NC&rft.au=Rudikoff, S&rft.au=Aaronson, SA&rft.au=Varmus, HE&rft.au=Rubin, JS&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21233&rfr_id=info:sid/en.wikipedia.org:Frizzled-10" class="Z3988">
• Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.10164-9&rft.date=1998-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21479#id-name=PMC&rft_id=info:pmid/9707618&rft_id=info:doi/10.1073/pnas.95.17.10164&rft_id=info:bibcode/1998PNAS...9510164T&rft.aulast=Tanaka&rft.aufirst=S&rft.au=Akiyoshi, T&rft.au=Mori, M&rft.au=Wands, JR&rft.au=Sugimachi, K&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21479&rfr_id=info:sid/en.wikipedia.org:Frizzled-10" class="Z3988">
• Kumar S, Connor JR, Dodds RA, Halsey W, Van Horn M, Mao J, Sathe G, Mui P, Agarwal P, Badger AM, Lee JC, Gowen M, Lark MW (Oct 2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthritis and Cartilage. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177.641-53&rft.date=2001-10&rft_id=info:doi/10.1053/joca.2001.0421&rft_id=info:pmid/11597177&rft.aulast=Kumar&rft.aufirst=S&rft.au=Connor, JR&rft.au=Dodds, RA&rft.au=Halsey, W&rft.au=Van Horn, M&rft.au=Mao, J&rft.au=Sathe, G&rft.au=Mui, P&rft.au=Agarwal, P&rft.au=Badger, AM&rft.au=Lee, JC&rft.au=Gowen, M&rft.au=Lark, MW&rft_id=https://doi.org/10.1053%2Fjoca.2001.0421&rfr_id=info:sid/en.wikipedia.org:Frizzled-10" class="Z3988">
• Terasaki H, Saitoh T, Shiokawa K, Katoh M (Feb 2002). "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway". International Journal of Molecular Medicine. 9 (2): 107–12. doi:10.3892/ijmm.9.2.107. PMID 11786918.107-12&rft.date=2002-02&rft_id=info:doi/10.3892/ijmm.9.2.107&rft_id=info:pmid/11786918&rft.aulast=Terasaki&rft.aufirst=H&rft.au=Saitoh, T&rft.au=Shiokawa, K&rft.au=Katoh, M&rfr_id=info:sid/en.wikipedia.org:Frizzled-10" class="Z3988">
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.81-90&rft.date=2004-06&rft_id=https://api.semanticscholar.org/CorpusID:32817238#id-name=S2CID&rft_id=info:pmid/15370539&rft_id=info:doi/10.1080/13816810490514270&rft.aulast=Omoto&rft.aufirst=S&rft.au=Hayashi, T&rft.au=Kitahara, K&rft.au=Takeuchi, T&rft.au=Ueoka, Y&rfr_id=info:sid/en.wikipedia.org:Frizzled-10" class="Z3988">

External links

• "Frizzled Receptors: FZD₁₀". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.
• FZD10 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.