VEL-101, formerly FR104, is an experimental monovalent, pegylated fab' antibody against CD28. It is developed for transplant rejection and autoimmune diseases.[1][2][3][4][5]
References
edit- ^ Ville, Simon; Poirier, Nicolas; Branchereau, Julien; Charpy, Vianney; Pengam, Sabrina; Nerriere-Daguin, Véronique; Le Bas-Bernardet, Stéphanie; Coulon, Flora; Mary, Caroline; Chenouard, Alexis; Hervouet, Jeremy; Minault, David; Nedellec, Steven; Renaudin, Karine; Vanhove, Bernard; Blancho, Gilles (December 2016). "Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection". Journal of the American Society of Nephrology. 27 (12): 3577–3588. doi:10.1681/ASN.2015070774. PMC 5118475.3577-3588&rft.date=2016-12&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118475#id-name=PMC&rft_id=info:doi/10.1681/ASN.2015070774&rft.aulast=Ville&rft.aufirst=Simon&rft.au=Poirier, Nicolas&rft.au=Branchereau, Julien&rft.au=Charpy, Vianney&rft.au=Pengam, Sabrina&rft.au=Nerriere-Daguin, Véronique&rft.au=Le Bas-Bernardet, Stéphanie&rft.au=Coulon, Flora&rft.au=Mary, Caroline&rft.au=Chenouard, Alexis&rft.au=Hervouet, Jeremy&rft.au=Minault, David&rft.au=Nedellec, Steven&rft.au=Renaudin, Karine&rft.au=Vanhove, Bernard&rft.au=Blancho, Gilles&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118475&rfr_id=info:sid/en.wikipedia.org:VEL-101" class="Z3988">
- ^ Zhang, T.; Gheorghe, B.; Sun, W.; Rybak, E.; Harris, D.; Sievert, E.; Burdorf, L.; Cheng, X.; Vanhove, B.; Azimzadeh, A.; Pierson, R. Iii (15 July 2014). "Effect of FR104, a Novel Anti-CD28 Fab, in Monkey Cardiac Allograft Transplantation.: Abstract# 1490". Transplantation. 98: 33. ISSN 0041-1337.
- ^ Poirier, N.; Mary, C.; Dilek, N.; Hervouet, J.; Minault, D.; Blancho, G.; Vanhove, B. (October 2012). "Preclinical Efficacy and Immunological Safety of FR104, an Antagonist Anti-CD28 Monovalent Fab′ Antibody". American Journal of Transplantation. 12 (10): 2630–2640. doi:10.1111/j.1600-6143.2012.04164.x.2630-2640&rft.date=2012-10&rft_id=info:doi/10.1111/j.1600-6143.2012.04164.x&rft.aulast=Poirier&rft.aufirst=N.&rft.au=Mary, C.&rft.au=Dilek, N.&rft.au=Hervouet, J.&rft.au=Minault, D.&rft.au=Blancho, G.&rft.au=Vanhove, B.&rft_id=https://doi.org/10.1111%2Fj.1600-6143.2012.04164.x&rfr_id=info:sid/en.wikipedia.org:VEL-101" class="Z3988">
- ^ Poirier, N.; Dilek, N.; Mary, C.; Ville, S.; Coulon, F.; Branchereau, J.; Tillou, X.; Charpy, V.; Pengam, S.; Nerriere-Daguin, V.; Hervouet, J.; Minault, D.; Le Bas-Bernardet, S.; Renaudin, K.; Vanhove, B.; Blancho, G. (February 2015). "FR104, an Antagonist Anti-CD28 Monovalent Fab' Antibody, Prevents Alloimmunization and Allows Calcineurin Inhibitor Minimization in Nonhuman Primate Renal Allograft". American Journal of Transplantation. 15 (1): 88–100. doi:10.1111/ajt.12964.88-100&rft.date=2015-02&rft_id=info:doi/10.1111/ajt.12964&rft.aulast=Poirier&rft.aufirst=N.&rft.au=Dilek, N.&rft.au=Mary, C.&rft.au=Ville, S.&rft.au=Coulon, F.&rft.au=Branchereau, J.&rft.au=Tillou, X.&rft.au=Charpy, V.&rft.au=Pengam, S.&rft.au=Nerriere-Daguin, V.&rft.au=Hervouet, J.&rft.au=Minault, D.&rft.au=Le Bas-Bernardet, S.&rft.au=Renaudin, K.&rft.au=Vanhove, B.&rft.au=Blancho, G.&rft_id=https://doi.org/10.1111%2Fajt.12964&rfr_id=info:sid/en.wikipedia.org:VEL-101" class="Z3988">
- ^ Poirier, Nicolas; Blancho, Gilles; Hiance, Maryvonne; Mary, Caroline; Van Assche, Tim; Lempoels, Jos; Ramael, Steven; Wang, Weirong; Thepenier, Virginie; Braudeau, Cecile; Salabert, Nina; Josien, Regis; Anderson, Ian; Gourley, Ian; Soulillou, Jean-Paul; Coquoz, Didier; Vanhove, Bernard (15 December 2016). "First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28". The Journal of Immunology. 197 (12): 4593–4602. doi:10.4049/jimmunol.1601538.4593-4602&rft.date=2016-12-15&rft_id=info:doi/10.4049/jimmunol.1601538&rft.aulast=Poirier&rft.aufirst=Nicolas&rft.au=Blancho, Gilles&rft.au=Hiance, Maryvonne&rft.au=Mary, Caroline&rft.au=Van Assche, Tim&rft.au=Lempoels, Jos&rft.au=Ramael, Steven&rft.au=Wang, Weirong&rft.au=Thepenier, Virginie&rft.au=Braudeau, Cecile&rft.au=Salabert, Nina&rft.au=Josien, Regis&rft.au=Anderson, Ian&rft.au=Gourley, Ian&rft.au=Soulillou, Jean-Paul&rft.au=Coquoz, Didier&rft.au=Vanhove, Bernard&rft_id=https://doi.org/10.4049%2Fjimmunol.1601538&rfr_id=info:sid/en.wikipedia.org:VEL-101" class="Z3988">