FLII

FLII
Identifiers
Aliases	FLII, FLI, FLIL, Fli1, actin remodeling protein, FLII actin remodeling protein
External IDs	OMIM: 600362; MGI: 1342286; HomoloGene: 11092; GeneCards: FLII; OMA:FLII - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,258,738 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,618,089 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; spleen; ; mucosa of transverse colon; ; Pituitary Gland; ; anterior pituitary; ; minor salivary glands; ; right lobe of thyroid gland;
	Top expressed in
	Ileal epithelium; ; choroid plexus of fourth ventricle; ; granulocyte; ; cardiac muscle tissue of left ventricle; ; lactiferous gland; ; tracheobronchial tree; ; internal carotid artery; ; mesenteric lymph nodes; ; right lung lobe; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; actin filament binding;
Cellular component	cell junction; cytoskeleton; brush border; nucleus; focal adhesion; nucleoplasm; microtubule organizing center; cytoplasm; cytosol;
Biological process	multicellular organism development; actin filament severing; regulation of transcription, DNA-templated; actin cytoskeleton organization; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	2314
	14248
	ENSG00000177731; ENSG00000284571
	ENSMUSG00000002812
	Q13045
	Q9JJ28
	NM_001256264; NM_001256265; NM_002018
	NM_022009; NM_001302207
	NP_001243193; NP_001243194; NP_002009
	NP_001289136; NP_071292
	Wikidata
View/Edit Human	View/Edit Mouse

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.^[5]^[6]

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.^[7] The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[6]

Interactions

FLII has been shown to interact with LRRFIP1^[8]^[9] and TRAF interacting protein.^[10]

References

^ ^a ^b ^c ENSG00000284571 GRCh38: Ensembl release 89: ENSG00000177731, ENSG00000284571 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002812 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336. PMID 7825574.175-82&rft.date=1995-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801336#id-name=PMC&rft_id=info:pmid/7825574&rft.aulast=Chen&rft.aufirst=KS&rft.au=Gunaratne, PH&rft.au=Hoheisel, JD&rft.au=Young, IG&rft.au=Miklos, GL&rft.au=Greenberg, F&rft.au=Shaffer, LG&rft.au=Campbell, HD&rft.au=Lupski, JR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801336&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
^ ^a ^b "Entrez Gene: FLII flightless I homolog (Drosophila)".
^ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.775-95&rft.date=2013&rft_id=https://api.semanticscholar.org/CorpusID:205643538#id-name=S2CID&rft_id=info:pmid/24155256&rft_id=info:doi/10.1002/cm.21149&rft.aulast=Ghoshdastider&rft.aufirst=U&rft.au=Popp, D&rft.au=Burtnick, LD&rft.au=Robinson, RC&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
^ Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. ISSN 0021-9258. PMID 9525888.7920-7&rft.date=1998-04&rft.issn=0021-9258&rft_id=info:pmid/9525888&rft_id=info:doi/10.1074/jbc.273.14.7920&rft.aulast=Liu&rft.aufirst=Y T&rft.au=Yin H L&rft_id=https://doi.org/10.1074%2Fjbc.273.14.7920&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
^ Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.146-57&rft.date=1999-06&rft.issn=0888-7543&rft_id=info:pmid/10366446&rft_id=info:doi/10.1006/geno.1999.5817&rft.aulast=Fong&rft.aufirst=K S&rft.au=de Couet H G&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
^ Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.3460-7&rft.date=1998-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147727#id-name=PMC&rft.issn=0305-1048&rft_id=info:pmid/9671805&rft_id=info:doi/10.1093/nar/26.15.3460&rft.aulast=Wilson&rft.aufirst=S A&rft.au=Brown E C&rft.au=Kingsman A J&rft.au=Kingsman S M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147727&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">

Campbell HD, Schimansky T, Claudianos C, et al. (1994). "The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11386–90. Bibcode:1993PNAS...9011386C. doi:10.1073/pnas.90.23.11386. PMC 47987. PMID 8248259.11386-90&rft.date=1994&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC47987#id-name=PMC&rft_id=info:pmid/8248259&rft_id=info:doi/10.1073/pnas.90.23.11386&rft_id=info:bibcode/1993PNAS...9011386C&rft.aulast=Campbell&rft.aufirst=HD&rft.au=Schimansky, T&rft.au=Claudianos, C&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC47987&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Campbell HD, Fountain S, Young IG, et al. (1997). "Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL". Genomics. 42 (1): 46–54. doi:10.1006/geno.1997.4709. PMID 9177775.46-54&rft.date=1997&rft_id=info:doi/10.1006/geno.1997.4709&rft_id=info:pmid/9177775&rft.aulast=Campbell&rft.aufirst=HD&rft.au=Fountain, S&rft.au=Young, IG&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Liu YT, Yin HL (1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.7920-7&rft.date=1998&rft_id=info:doi/10.1074/jbc.273.14.7920&rft_id=info:pmid/9525888&rft.aulast=Liu&rft.aufirst=YT&rft.au=Yin, HL&rft_id=https://doi.org/10.1074%2Fjbc.273.14.7920&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I." Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.3460-7&rft.date=1998&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147727#id-name=PMC&rft_id=info:pmid/9671805&rft_id=info:doi/10.1093/nar/26.15.3460&rft.aulast=Wilson&rft.aufirst=SA&rft.au=Brown, EC&rft.au=Kingsman, AJ&rft.au=Kingsman, SM&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147727&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Fong KS, de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.146-57&rft.date=1999&rft_id=info:doi/10.1006/geno.1999.5817&rft_id=info:pmid/10366446&rft.aulast=Fong&rft.aufirst=KS&rft.au=de Couet, HG&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Davy DA, Campbell HD, Fountain S, et al. (2001). "The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases". J. Cell Sci. 114 (Pt 3): 549–62. doi:10.1242/jcs.114.3.549. PMID 11171324.549-62&rft.date=2001&rft_id=info:doi/10.1242/jcs.114.3.549&rft_id=info:pmid/11171324&rft.aulast=Davy&rft.aufirst=DA&rft.au=Campbell, HD&rft.au=Fountain, S&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Campbell HD, Fountain S, McLennan IS, et al. (2002). "Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development". Mol. Cell. Biol. 22 (10): 3518–26. doi:10.1128/MCB.22.10.3518-3526.2002. PMC 133791. PMID 11971982.3518-26&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133791#id-name=PMC&rft_id=info:pmid/11971982&rft_id=info:doi/10.1128/MCB.22.10.3518-3526.2002&rft.aulast=Campbell&rft.aufirst=HD&rft.au=Fountain, S&rft.au=McLennan, IS&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133791&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186863. PMID 11997338.713-28&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186863#id-name=PMC&rft_id=info:pmid/11997338&rft_id=info:doi/10.1101/gr.73702&rft.aulast=Bi&rft.aufirst=W&rft.au=Yan, J&rft.au=Stankiewicz, P&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186863&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.566-9&rft.date=2004&rft_id=https://api.semanticscholar.org/CorpusID:23783563#id-name=S2CID&rft_id=info:pmid/12665801&rft_id=info:doi/10.1038/nbt810&rft.aulast=Gevaert&rft.aufirst=K&rft.au=Goethals, M&rft.au=Martens, L&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Lee YH, Campbell HD, Stallcup MR (2004). "Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity". Mol. Cell. Biol. 24 (5): 2103–17. doi:10.1128/MCB.24.5.2103-2117.2004. PMC 350567. PMID 14966289.2103-17&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC350567#id-name=PMC&rft_id=info:pmid/14966289&rft_id=info:doi/10.1128/MCB.24.5.2103-2117.2004&rft.aulast=Lee&rft.aufirst=YH&rft.au=Campbell, HD&rft.au=Stallcup, MR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC350567&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.12130-5&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446#id-name=PMC&rft_id=info:pmid/15302935&rft_id=info:doi/10.1073/pnas.0404720101&rft_id=info:bibcode/2004PNAS..10112130B&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Jedrychowski, M&rft.au=Schwartz, D&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Wang T, Chuang TH, Ronni T, et al. (2006). "Flightless I homolog negatively modulates the TLR pathway". J. Immunol. 176 (3): 1355–62. doi:10.4049/jimmunol.176.3.1355. PMID 16424162.1355-62&rft.date=2006&rft_id=info:doi/10.4049/jimmunol.176.3.1355&rft_id=info:pmid/16424162&rft.aulast=Wang&rft.aufirst=T&rft.au=Chuang, TH&rft.au=Ronni, T&rft_id=https://doi.org/10.4049%2Fjimmunol.176.3.1355&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.1285-92&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:14294292#id-name=S2CID&rft_id=info:pmid/16964243&rft_id=info:doi/10.1038/nbt1240&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Villén, J&rft.au=Gerber, SA&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.635-48&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:7827573#id-name=S2CID&rft_id=info:pmid/17081983&rft_id=info:doi/10.1016/j.cell.2006.09.026&rft.aulast=Olsen&rft.aufirst=JV&rft.au=Blagoev, B&rft.au=Gnad, F&rft_id=https://doi.org/10.1016%2Fj.cell.2006.09.026&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000284571 GRCh38: Ensembl release 89: ENSG00000177731, ENSG00000284571 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002812 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7825574-5] Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336. PMID 7825574.175-82&rft.date=1995-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801336#id-name=PMC&rft_id=info:pmid/7825574&rft.aulast=Chen&rft.aufirst=KS&rft.au=Gunaratne, PH&rft.au=Hoheisel, JD&rft.au=Young, IG&rft.au=Miklos, GL&rft.au=Greenberg, F&rft.au=Shaffer, LG&rft.au=Campbell, HD&rft.au=Lupski, JR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801336&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">

[entrez-6] "Entrez Gene: FLII flightless I homolog (Drosophila)".

[pmid24155256-7] Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.775-95&rft.date=2013&rft_id=https://api.semanticscholar.org/CorpusID:205643538#id-name=S2CID&rft_id=info:pmid/24155256&rft_id=info:doi/10.1002/cm.21149&rft.aulast=Ghoshdastider&rft.aufirst=U&rft.au=Popp, D&rft.au=Burtnick, LD&rft.au=Robinson, RC&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">

[pmid9525888-8] Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. ISSN 0021-9258. PMID 9525888.7920-7&rft.date=1998-04&rft.issn=0021-9258&rft_id=info:pmid/9525888&rft_id=info:doi/10.1074/jbc.273.14.7920&rft.aulast=Liu&rft.aufirst=Y T&rft.au=Yin H L&rft_id=https://doi.org/10.1074%2Fjbc.273.14.7920&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">

[pmid10366446-9] Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.146-57&rft.date=1999-06&rft.issn=0888-7543&rft_id=info:pmid/10366446&rft_id=info:doi/10.1006/geno.1999.5817&rft.aulast=Fong&rft.aufirst=K S&rft.au=de Couet H G&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">

[pmid9671805-10] Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.3460-7&rft.date=1998-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147727#id-name=PMC&rft.issn=0305-1048&rft_id=info:pmid/9671805&rft_id=info:doi/10.1093/nar/26.15.3460&rft.aulast=Wilson&rft.aufirst=S A&rft.au=Brown E C&rft.au=Kingsman A J&rft.au=Kingsman S M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147727&rfr_id=info:sid/en.wikipedia.org:FLII" class="Z3988">

[5]

[6]

[1]

[2]

[3]

[4]

[7]

[8]

[9]

[10]

FLII

Interactions

References

Further reading