FGD2

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

FGD2
Identifiers
Aliases	FGD2, ZFYVE4, FYVE, RhoGEF and PH domain containing 2
External IDs	OMIM: 605091; MGI: 1347084; HomoloGene: 8438; GeneCards: FGD2; OMA:FGD2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.2 Start 37,005,646 bp End 37,029,069 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 15.26 cM|17 A3.3 Start 29,360,914 bp End 29,379,661 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spleen granulocyte epithelium of nasopharynx internal globus pallidus lymph node buccal mucosa cell blood trabecular bone cardia Top expressed in otic vesicle saccule spleen granulocyte blood otic placode islet of Langerhans stroma of bone marrow mesenteric lymph nodes epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylinositol phosphate binding metal ion binding small GTPase binding protein binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol endosome Golgi apparatus cell projection early endosome membrane membrane ruffle plasma membrane ruffle membrane early endosome cytoskeleton nucleus lamellipodium Biological process positive regulation of JUN kinase activity regulation of GTPase activity filopodium assembly cytoskeleton organization regulation of cell shape positive regulation of apoptotic process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction actin cytoskeleton organization G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221472 26382 Ensembl ENSG00000146192 ENSMUSG00000024013 UniProt Q7Z6J4 Q8BY35 RefSeq (mRNA) NM_173558 NM_001159538 NM_013710 RefSeq (protein) NP_775829 NP_001153010 NP_038738 Location (UCSC) Chr 6: 37.01 – 37.03 Mb Chr 17: 29.36 – 29.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

It is a member of the FYVE, RhoGEF and PH domain containing family.

See also

• FYVE domain (zinc finger domain)
• RhoGEF domain (with guanine nucleotide exchange factor activity)
• PH domain (pleckstrin homology domain)

Further reading

• Salehi AH, Xanthoudakis S, Barker PA (2002). "NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway". J. Biol. Chem. 277 (50): 48043–50. doi:10.1074/jbc.M205324200. PMID 12376548.48043-50&rft.date=2002&rft_id=info:doi/10.1074/jbc.M205324200&rft_id=info:pmid/12376548&rft.aulast=Salehi&rft.aufirst=AH&rft.au=Xanthoudakis, S&rft.au=Barker, PA&rft_id=https://doi.org/10.1074%2Fjbc.M205324200&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.805-11&rft.date=2003&rft_id=info:pmid/14574404&rft_id=info:doi/10.1038/nature02055&rft_id=info:bibcode/2003Natur.425..805M&rft.aulast=Mungall&rft.aufirst=AJ&rft.au=Palmer, SA&rft.au=Sims, SK&rft_id=https://doi.org/10.1038%2Fnature02055&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Hattori A, Okumura K, Nagase T, et al. (2000). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.357-66&rft.date=2000&rft_id=info:doi/10.1093/dnares/7.6.357&rft_id=info:pmid/11214971&rft.aulast=Hattori&rft.aufirst=A&rft.au=Okumura, K&rft.au=Nagase, T&rft_id=https://doi.org/10.1093%2Fdnares%2F7.6.357&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Pasteris NG, Gorski JL (1999). "Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues". Genomics. 60 (1): 57–66. doi:10.1006/geno.1999.5903. PMID 10458911.57-66&rft.date=1999&rft_id=info:doi/10.1006/geno.1999.5903&rft_id=info:pmid/10458911&rft.aulast=Pasteris&rft.aufirst=NG&rft.au=Gorski, JL&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Harrington AW, Kim JY, Yoon SO (2002). "Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis". J. Neurosci. 22 (1): 156–66. doi:10.1523/JNEUROSCI.22-01-00156.2002. PMC 6757583. PMID 11756498.156-66&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757583#id-name=PMC&rft_id=info:pmid/11756498&rft_id=info:doi/10.1523/JNEUROSCI.22-01-00156.2002&rft.aulast=Harrington&rft.aufirst=AW&rft.au=Kim, JY&rft.au=Yoon, SO&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757583&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Rabizadeh S, Bredesen DE (2003). "Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR)". Cytokine Growth Factor Rev. 14 (3–4): 225–39. doi:10.1016/S1359-6101(03)00018-2. PMID 12787561.3–4&rft.pages=225-39&rft.date=2003&rft_id=info:doi/10.1016/S1359-6101(03)50018-2&rft_id=info:pmid/12787561&rft.aulast=Rabizadeh&rft.aufirst=S&rft.au=Bredesen, DE&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Huber C, Mårtensson A, Bokoch GM, et al. (2008). "FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles". J. Biol. Chem. 283 (49): 34002–12. doi:10.1074/jbc.M803957200. PMC 2590680. PMID 18838382.34002-12&rft.date=2008&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590680#id-name=PMC&rft_id=info:pmid/18838382&rft_id=info:doi/10.1074/jbc.M803957200&rft.aulast=Huber&rft.aufirst=C&rft.au=Mårtensson, A&rft.au=Bokoch, GM&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590680&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">
• Delague V, Jacquier A, Hamadouche T, et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H". Am. J. Hum. Genet. 81 (1): 1–16. doi:10.1086/518428. PMC 1950914. PMID 17564959.1-16&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950914#id-name=PMC&rft_id=info:pmid/17564959&rft_id=info:doi/10.1086/518428&rft.aulast=Delague&rft.aufirst=V&rft.au=Jacquier, A&rft.au=Hamadouche, T&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950914&rfr_id=info:sid/en.wikipedia.org:FGD2" class="Z3988">