Ethenzamide (2-ethoxybenzamide) is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.[1][2] It is also an ingredient in numerous cold medications and many prescription analgesics.[citation needed] It is used as an over-the-counter drug in Japan, often in combination with caffeine and acetaminophen, where it is marketed for uses including toothache, menstrual cramps, headache, and fever.[3]

Ethenzamide
Clinical data
ATC code
Identifiers
  • 2-ethoxybenzamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.012.133 Edit this at Wikidata
Chemical and physical data
FormulaC9H11NO2
Molar mass165.192 g·mol−1
3D model (JSmol)
  • O=C(c1ccccc1OCC)N
  • InChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11) checkY
  • Key:SBNKFTQSBPKMBZ-UHFFFAOYSA-N checkY
  (verify)

It is metabolized in vivo into salicylamide.[4]

References

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  1. ^ Darias V, Bravo L, Abdallah SS, Sánchez Mateo CC, Expósito-Orta MA, Lissavetsky J, Manzanares J (February 1992). "Synthesis and preliminary pharmacological study of thiophene analogues of the antipyretic and analgesic agent ethenzamide". Archiv der Pharmazie. 325 (2): 83–7. doi:10.1002/ardp.19923250206. PMID 1605721. S2CID 28098596.83-7&rft.date=1992-02&rft_id=https://api.semanticscholar.org/CorpusID:28098596#id-name=S2CID&rft_id=info:pmid/1605721&rft_id=info:doi/10.1002/ardp.19923250206&rft.aulast=Darias&rft.aufirst=V&rft.au=Bravo, L&rft.au=Abdallah, SS&rft.au=Sánchez Mateo, CC&rft.au=Expósito-Orta, MA&rft.au=Lissavetsky, J&rft.au=Manzanares, J&rfr_id=info:sid/en.wikipedia.org:Ethenzamide" class="Z3988">
  2. ^ Wang PJ, Guo HR (2004). "Frequent analgesics consumption in migraineurs: Comparison between chronic and episodic migraineurs". The Journal of Headache and Pain. 5 (1): 30–35. doi:10.1007/s10194-004-0065-x. PMC 3452147.30-35&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452147#id-name=PMC&rft_id=info:doi/10.1007/s10194-004-0065-x&rft.aulast=Wang&rft.aufirst=PJ&rft.au=Guo, HR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452147&rfr_id=info:sid/en.wikipedia.org:Ethenzamide" class="Z3988">
  3. ^ "OTC Pain Relief Medicine in Japan". Life Abroad. Retrieved March 22, 2021.
  4. ^ "エテンザミド" [Ethenzamide] (in Japanese). Retrieved March 22, 2021.