Ephrin B3

Ephrin-B3 is a protein that in humans is encoded by the EFNB3 gene.

EFNB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BKF
Identifiers
Aliases	EFNB3, EFL6, EPLG8, LERK8, ephrin B3
External IDs	OMIM: 602297; MGI: 109196; HomoloGene: 1076; GeneCards: EFNB3; OMA:EFNB3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 7,705,202 bp End 7,711,372 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B3|11 42.8 cM Start 69,444,918 bp End 69,451,031 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus nucleus accumbens endothelial cell prefrontal cortex Brodmann area 46 ganglionic eminence dorsolateral prefrontal cortex caudate nucleus entorhinal cortex ventricular zone Top expressed in entorhinal cortex CA3 field dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord perirhinal cortex superior frontal gyrus nucleus of stria terminalis primary visual cortex subiculum suprachiasmatic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ephrin receptor binding transmembrane-ephrin receptor activity virus receptor activity protein tyrosine kinase activity Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane hippocampal mossy fiber to CA3 synapse glutamatergic synapse integral component of presynaptic membrane integral component of postsynaptic density membrane Biological process ephrin receptor signaling pathway multicellular organism development cell-cell signaling viral entry into host cell T cell costimulation cell differentiation viral process axon choice point recognition nervous system development adult walking behavior axon guidance peptidyl-tyrosine phosphorylation negative regulation of axonogenesis trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1949 13643 Ensembl ENSG00000108947 ENSMUSG00000003934 UniProt Q15768 O35393 RefSeq (mRNA) NM_001406 NM_007911 RefSeq (protein) NP_001397 NP_031937 Location (UCSC) Chr 17: 7.71 – 7.71 Mb Chr 11: 69.44 – 69.45 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases. EPH receptors typically have a single kinase domain and an extracellular region containing a Cysteine-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997) based on their structures and sequence relationships. Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Ephrin-B ligands also contain an intracellular tail with highly conserved tyrosine residues and a PDZ-binding motif at the C-terminus. This tail functions as a mechanism for reverse signaling, where signaling occurs into the ligand-containing cell, as opposed to the cell with the receptor. Upon receptor-ligand interaction the tyrosine residues become phosphorylated and there is recruitment of PDZ domain-containing proteins. The Eph family of receptors are similarly divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphrinB3 has been implicated in mediating various developmental events, particularly in the nervous system. EphrinB3 reverse signaling is important for axon pruning and synapse and spine formation during postnatal development of the nervous system. Previous work has also shown that signaling through this ligand is important for radial migration during cortical development. Moreover, levels of EFNB3 expression are particularly high in several forebrain subregions compared to other brain subregions, and may play a pivotal role in forebrain function. It has been suggested that ephrinB3 signaling is necessary for synaptic plasticity to occur in the hippocampus; this implicates ephrinB3 as a major player in learning and memory. More recently, ephrinB3 has been shown to regulate proliferation of neural stem cells in the adult subventricular zone (SVZ).

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.309-45&rft.date=1998&rft_id=info:doi/10.1146/annurev.neuro.21.1.309&rft_id=info:pmid/9530499&rft.aulast=Flanagan&rft.aufirst=JG&rft.au=Vanderhaeghen, P&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.151-81&rft.date=1998&rft_id=info:doi/10.1016/S0163-7258(97)00112-5&rft_id=info:pmid/9576626&rft.au=Zhou R&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID 10207129.2033-44&rft.date=1999&rft_id=info:doi/10.1242/dev.126.10.2033&rft_id=info:pmid/10207129&rft.aulast=Holder&rft.aufirst=N&rft.au=Klein, R&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216.177-244&rft.date=2000&rft_id=info:pmid/10730216&rft_id=info:doi/10.1016/S0074-7696(00)96005-4&rft.isbn=978-0-12-364600-2&rft.au=Wilkinson DG&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.993-1002&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1692797#id-name=PMC&rft_id=info:pmid/11128993&rft_id=info:doi/10.1098/rstb.2000.0635&rft.aulast=Xu&rft.aufirst=Q&rft.au=Mellitzer, G&rft.au=Wilkinson, DG&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1692797&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.155-64&rft.date=2001&rft_id=https://api.semanticscholar.org/CorpusID:205014301#id-name=S2CID&rft_id=info:pmid/11256076&rft_id=info:doi/10.1038/35058515&rft.au=Wilkinson DG&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Gale NW, Flenniken A, Compton DC, et al. (1996). "Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments". Oncogene. 13 (6): 1343–52. PMID 8808709.1343-52&rft.date=1996&rft_id=info:pmid/8808709&rft.aulast=Gale&rft.aufirst=NW&rft.au=Flenniken, A&rft.au=Compton, DC&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.403-4&rft.date=1997&rft_id=https://api.semanticscholar.org/CorpusID:26773768#id-name=S2CID&rft_id=info:pmid/9267020&rft_id=info:doi/10.1016/S0092-8674(00)80500-0&rft.au=Ephnomenclaturecommittee&rft_id=https://doi.org/10.1016%2FS0092-8674%2800%2980500-0&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Bergemann AD, Zhang L, Chiang MK, et al. (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube". Oncogene. 16 (4): 471–80. doi:10.1038/sj.onc.1201557. PMID 9484836.471-80&rft.date=1998&rft_id=info:doi/10.1038/sj.onc.1201557&rft_id=info:pmid/9484836&rft.aulast=Bergemann&rft.aufirst=AD&rft.au=Zhang, L&rft.au=Chiang, MK&rft_id=https://doi.org/10.1038%2Fsj.onc.1201557&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Brückner K, Pablo Labrador J, Scheiffele P, et al. (1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron. 22 (3): 511–24. doi:10.1016/S0896-6273(00)80706-0. PMID 10197531.511-24&rft.date=1999&rft_id=info:doi/10.1016/S0896-6273(00)80706-0&rft_id=info:pmid/10197531&rft.aulast=Brückner&rft.aufirst=K&rft.au=Pablo Labrador, J&rft.au=Scheiffele, P&rft_id=https://doi.org/10.1016%2FS0896-6273%2800%2980706-0&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Liu W, Ahmad SA, Jung YD, et al. (2002). "Coexpression of ephrin-Bs and their receptors in colon carcinoma". Cancer. 94 (4): 934–9. doi:10.1002/cncr.10122. PMID 11920461. S2CID 25734266.934-9&rft.date=2002&rft_id=https://api.semanticscholar.org/CorpusID:25734266#id-name=S2CID&rft_id=info:pmid/11920461&rft_id=info:doi/10.1002/cncr.10122&rft.aulast=Liu&rft.aufirst=W&rft.au=Ahmad, SA&rft.au=Jung, YD&rft_id=https://doi.org/10.1002%2Fcncr.10122&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Takemoto M, Fukuda T, Sonoda R, et al. (2002). "Ephrin-B3-EphA4 interactions regulate the growth of specific thalamocortical axon populations in vitro". Eur. J. Neurosci. 16 (6): 1168–72. doi:10.1046/j.1460-9568.2002.02166.x. PMID 12383247. S2CID 7540058.1168-72&rft.date=2002&rft_id=https://api.semanticscholar.org/CorpusID:7540058#id-name=S2CID&rft_id=info:pmid/12383247&rft_id=info:doi/10.1046/j.1460-9568.2002.02166.x&rft.aulast=Takemoto&rft.aufirst=M&rft.au=Fukuda, T&rft.au=Sonoda, R&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:Ephrin B3" class="Z3988">