Dolichyl-phosphate beta-glucosyltransferase

In enzymology, a dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) is an enzyme that catalyzes the chemical reaction

dolichyl-phosphate beta-glucosyltransferase
Identifiers
EC no.2.4.1.117
CAS no.71061-42-2
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MetaCycmetabolic pathway
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UDP-glucose dolichyl phosphate UDP dolichyl beta-D-glucosyl phosphate

Thus, the two substrates of this enzyme are UDP-glucose and dolichyl phosphate, whereas its two products are UDP and dolichyl beta-D-glucosyl phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase. Other names in common use include polyprenyl phosphate:UDP-D-glucose glucosyltransferase, UDP-glucose dolichyl-phosphate glucosyltransferase, uridine diphosphoglucose-dolichol glucosyltransferase, UDP-glucose:dolichol phosphate glucosyltransferase, UDP-glucose:dolicholphosphoryl glucosyltransferase, UDP-glucose:dolichyl monophosphate glucosyltransferase, and UDP-glucose:dolichyl phosphate glucosyltransferase. This enzyme participates in n-glycan biosynthesis.

References

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  • Behrens NH, Leloir LF (1970). "Dolichol monophosphate glucose: an intermediate in glucose transfer in liver". Proc. Natl. Acad. Sci. U.S.A. 66 (1): 153–9. doi:10.1073/pnas.66.1.153. PMC 286101. PMID 5273893.153-9&rft.date=1970&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC286101#id-name=PMC&rft_id=info:pmid/5273893&rft_id=info:doi/10.1073/pnas.66.1.153&rft.aulast=Behrens&rft.aufirst=NH&rft.au=Leloir, LF&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC286101&rfr_id=info:sid/en.wikipedia.org:Dolichyl-phosphate beta-glucosyltransferase" class="Z3988">
  • Herscovics A, Bugge B, Jeanloz RW (1977). "Glucosyltransferase activity in calf pancreas microsomes. Formation of dolichyl D[14C]glucosyl phosphate and 14C-labeled lipid-linked oligosaccharides from UDP-D-[14C]glucose". J. Biol. Chem. 252 (7): 2271–7. doi:10.1016/S0021-9258(17)40550-3. PMID 849929.2271-7&rft.date=1977&rft_id=info:doi/10.1016/S0021-9258(17)40550-3&rft_id=info:pmid/849929&rft.aulast=Herscovics&rft.aufirst=A&rft.au=Bugge, B&rft.au=Jeanloz, RW&rft_id=https://doi.org/10.1016%2FS0021-9258%2817%2940550-3&rfr_id=info:sid/en.wikipedia.org:Dolichyl-phosphate beta-glucosyltransferase" class="Z3988">
  • Villemez CL, Carlo PL (1979). "Properties of a soluble polyprenyl phosphate: UDP-D-glucose glucosyltransferase". J. Biol. Chem. 254 (11): 4814–9. doi:10.1016/S0021-9258(17)30085-6. PMID 438216.4814-9&rft.date=1979&rft_id=info:doi/10.1016/S0021-9258(17)30085-6&rft_id=info:pmid/438216&rft.aulast=Villemez&rft.aufirst=CL&rft.au=Carlo, PL&rft_id=https://doi.org/10.1016%2FS0021-9258%2817%2930085-6&rfr_id=info:sid/en.wikipedia.org:Dolichyl-phosphate beta-glucosyltransferase" class="Z3988">