Divaplon

Divaplon
Clinical data
ATC code	none;
Identifiers
	IUPAC name (6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-yl)-phenylmethanone;
CAS Number	90808-12-1 ;
PubChem CID	65822;
ChemSpider	59234;
UNII	4AOV43246G;
ChEMBL	ChEMBL281164;
CompTox Dashboard (EPA)	DTXSID40238269 ;
Chemical and physical data
Formula	C17H17N3O2
Molar mass	295.342 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC1=C(N2C=C(N=C2N=C1OC)C(=O)C3=CC=CC=C3)C;
	InChI InChI=1S/C17H17N3O2/c1-4-13-11(2)20-10-14(18-17(20)19-16(13)22-3)15(21)12-8-6-5-7-9-12/h5-10H,4H2,1-3H3; Key:NRJVHCSYLGLURI-UHFFFAOYSA-N;
	(verify)

Divaplon (RU-32698) is a nonbenzodiazepine, anxiolytic and anticonvulsant drug from the imidazopyrimidine family of drugs. It acts as a partial agonist at the "benzodiazepine site" of the GABA_A receptor in the brain.^[1]^[2]^[3]

References

^ Feely M, Boyland P, Picardo A, Cox A, Gent JP (May 1989). "Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812". European Journal of Pharmacology. 164 (2): 377–80. doi:10.1016/0014-2999(89)90482-2. PMID 2759183.377-80&rft.date=1989-05&rft_id=info:doi/10.1016/0014-2999(89)90482-2&rft_id=info:pmid/2759183&rft.aulast=Feely&rft.aufirst=M&rft.au=Boyland, P&rft.au=Picardo, A&rft.au=Cox, A&rft.au=Gent, JP&rfr_id=info:sid/en.wikipedia.org:Divaplon" class="Z3988">
^ Sanger DJ, Joly D, Perrault G (September 1995). "Benzodiazepine (omega) receptor partial agonists and the acquisition of conditioned fear in mice". Psychopharmacology. 121 (1): 104–8. doi:10.1007/BF02245596. PMID 8539334. S2CID 32627339.104-8&rft.date=1995-09&rft_id=https://api.semanticscholar.org/CorpusID:32627339#id-name=S2CID&rft_id=info:pmid/8539334&rft_id=info:doi/10.1007/BF02245596&rft.aulast=Sanger&rft.aufirst=DJ&rft.au=Joly, D&rft.au=Perrault, G&rfr_id=info:sid/en.wikipedia.org:Divaplon" class="Z3988">
^ Pellón R, Ruíz A, Lamas E, Rodríguez C (February 2007). "Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats". Behavioural Pharmacology. 18 (1): 81–7. doi:10.1097/FBP.0b013e3280143212. PMID 17218801. S2CID 40188048.81-7&rft.date=2007-02&rft_id=https://api.semanticscholar.org/CorpusID:40188048#id-name=S2CID&rft_id=info:pmid/17218801&rft_id=info:doi/10.1097/FBP.0b013e3280143212&rft.aulast=Pellón&rft.aufirst=R&rft.au=Ruíz, A&rft.au=Lamas, E&rft.au=Rodríguez, C&rfr_id=info:sid/en.wikipedia.org:Divaplon" class="Z3988">

[1] Feely M, Boyland P, Picardo A, Cox A, Gent JP (May 1989). "Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812". European Journal of Pharmacology. 164 (2): 377–80. doi:10.1016/0014-2999(89)90482-2. PMID 2759183.377-80&rft.date=1989-05&rft_id=info:doi/10.1016/0014-2999(89)90482-2&rft_id=info:pmid/2759183&rft.aulast=Feely&rft.aufirst=M&rft.au=Boyland, P&rft.au=Picardo, A&rft.au=Cox, A&rft.au=Gent, JP&rfr_id=info:sid/en.wikipedia.org:Divaplon" class="Z3988">

[2] Sanger DJ, Joly D, Perrault G (September 1995). "Benzodiazepine (omega) receptor partial agonists and the acquisition of conditioned fear in mice". Psychopharmacology. 121 (1): 104–8. doi:10.1007/BF02245596. PMID 8539334. S2CID 32627339.104-8&rft.date=1995-09&rft_id=https://api.semanticscholar.org/CorpusID:32627339#id-name=S2CID&rft_id=info:pmid/8539334&rft_id=info:doi/10.1007/BF02245596&rft.aulast=Sanger&rft.aufirst=DJ&rft.au=Joly, D&rft.au=Perrault, G&rfr_id=info:sid/en.wikipedia.org:Divaplon" class="Z3988">

[3] Pellón R, Ruíz A, Lamas E, Rodríguez C (February 2007). "Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats". Behavioural Pharmacology. 18 (1): 81–7. doi:10.1097/FBP.0b013e3280143212. PMID 17218801. S2CID 40188048.81-7&rft.date=2007-02&rft_id=https://api.semanticscholar.org/CorpusID:40188048#id-name=S2CID&rft_id=info:pmid/17218801&rft_id=info:doi/10.1097/FBP.0b013e3280143212&rft.aulast=Pellón&rft.aufirst=R&rft.au=Ruíz, A&rft.au=Lamas, E&rft.au=Rodríguez, C&rfr_id=info:sid/en.wikipedia.org:Divaplon" class="Z3988">

[1]

[2]

[3]

Clinical data

ATC code	none
Identifiers
IUPAC name (6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-yl)-phenylmethanone
CAS Number	90808-12-1^Y
PubChem CID	65822
ChemSpider	59234
UNII	4AOV43246G
ChEMBL	ChEMBL281164
CompTox Dashboard (EPA)	DTXSID40238269
Chemical and physical data
Formula	C₁₇H₁₇N₃O₂
Molar mass	295.342 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCC1=C(N2C=C(N=C2N=C1OC)C(=O)C3=CC=CC=C3)C
InChI InChI=1S/C17H17N3O2/c1-4-13-11(2)20-10-14(18-17(20)19-16(13)22-3)15(21)12-8-6-5-7-9-12/h5-10H,4H2,1-3H3 Key:NRJVHCSYLGLURI-UHFFFAOYSA-N
(verify)