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| Comparison of the chemical structures of ribose (top) and deoxyribose (bottom). |
Deoxy sugars[1] are sugars that have had a hydroxyl group replaced with a hydrogen atom.
Examples include:
- Deoxyribose, or 2-deoxy-D-ribose, a constituent of DNA
- Fucose, or 6-deoxy-L-galactose, main component of fucoidan of brown algae, and present in N-linked glycans
- Fuculose, or 6-deoxy-L-tagatose, one of the important components of avian influenza virus particles
- Rhamnose, or 6-deoxy-L-mannose, present in plant glycosides
In Escherichia coli bacteria, deoxyribose sugars are synthesized via two different pathways - one pathway involves aldol condensation, whereas the other pathway is conversion of a ribose sugar into a deoxyribose sugar by means of changes on the nucleotide or nucleoside level. Deoxyribose is synthesized through the reduction of ribose. Deoxyribose is derived from the same precursor as ribose being that the reduction of the sugar with the extra hydroxyl group results in the deoxy-sugar, which has its hydroxyl group replaced with a hydrogen atom.[2]
Dideoxy sugars
editSome biologically important dideoxy sugars, sugars that have had two hydroxyl groups replaced with hydrogen atoms, include colitose and abequose.
(3,6-Dideoxy-L-xylo-hexose)
(3,6-Dideoxy-D-xylo-hexose)
See also
editReferences
edit- ^ "Deoxy sugars". Nature Publishing Group. Retrieved 22 May 2016.
- ^ Sable, Henry Z.; Wright, Elmer M.; Bagatell, Fillmore K. (1959-06-01). "Biosynthesis of Ribose and Deoxyribose in Escherichia coli". Journal of Biological Chemistry. 234 (6): 1369–1374. doi:10.1016/S0021-9258(18)70013-6. ISSN 1083-351X. PMID 13654380.
External links
edit- Deoxy Sugars at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview at qmul.ac.uk