Carboxy-lyases, also known as decarboxylases, are carbon–carbon lyases that add or remove a carboxyl group from organic compounds. These enzymes catalyze the decarboxylation of amino acids and alpha-keto acids.[1]
Classification and nomenclature
editCarboxy-lyases are categorized under EC number 4.1.1.[2] Usually, they are named after the substrate whose decarboxylation they catalyze, for example pyruvate decarboxylase catalyzes the decarboxylation of pyruvate.
Examples
edit- Aromatic-L-amino-acid decarboxylase
- Glutamate decarboxylase
- Histidine decarboxylase
- Ornithine decarboxylase
- Phosphoenolpyruvate carboxylase
- Pyruvate decarboxylase
- RuBisCO – the only carboxylase that leads to a net fixation of carbon dioxide
- Uridine monophosphate synthetase
- Uroporphyrinogen III decarboxylase
- enoyl-CoA carboxylases/reductases (ECRs)[3]
See also
editReferences
edit- ^ Iding, H.; Siegert, P.; Mesch, K.; Pohl, M. (1998). "Application of α-keto acid decarboxylases in biotransformations". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1385 (2): 307–322. doi:10.1016/S0167-4838(98)00076-4. PMID 9655924.307-322&rft.date=1998&rft_id=info:doi/10.1016/S0167-4838(98)50076-4&rft_id=info:pmid/9655924&rft.aulast=Iding&rft.aufirst=H.&rft.au=Siegert, P.&rft.au=Mesch, K.&rft.au=Pohl, M.&rfr_id=info:sid/en.wikipedia.org:Carboxy-lyases" class="Z3988">
- ^ "E.C.4.1.1.- Carboxy-lyases". www.biochem.ucl.ac.uk. Archived from the original on 2006-10-13. Retrieved 2006-11-08.
- ^ Schwander, Thomas; Schada von Borzyskowski, Lennart; Burgener, Simon; Cortina, Niña Socorro; Erb, Tobias J. (2016). "A synthetic pathway for the fixation of carbon dioxide in vitro". Science. 354 (6314): 900–904. Bibcode:2016Sci...354..900S. doi:10.1126/science.aah5237. PMC 5892708. PMID 27856910.900-904&rft.date=2016&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892708#id-name=PMC&rft_id=info:pmid/27856910&rft_id=info:doi/10.1126/science.aah5237&rft_id=info:bibcode/2016Sci...354..900S&rft.aulast=Schwander&rft.aufirst=Thomas&rft.au=Schada von Borzyskowski, Lennart&rft.au=Burgener, Simon&rft.au=Cortina, Niña Socorro&rft.au=Erb, Tobias J.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892708&rfr_id=info:sid/en.wikipedia.org:Carboxy-lyases" class="Z3988">
External links
edit- Carboxy-Lyases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
