DTL (gene)

DTL
Identifiers
Aliases	DTL, CDT2, DCAF2, L2RAMP, denticleless E3 ubiquitin protein ligase homolog
External IDs	OMIM: 610617; MGI: 1924093; HomoloGene: 32313; GeneCards: DTL; OMA:DTL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	212,107,400 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	191,307,656 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; trabecular bone; ; embryo; ; testicle; ; ventricular zone; ; bone marrow; ; ganglionic eminence; ; gonad; ; bone marrow cells; ; sperm;
	Top expressed in
	mandibular prominence; ; maxillary prominence; ; zygote; ; secondary oocyte; ; ureter; ; lumbar spinal ganglion; ; primitive streak; ; primary oocyte; ; hand; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding;
Cellular component	centrosome; nuclear membrane; membrane; chromosome; microtubule organizing center; nucleolus; Cul4A-RING E3 ubiquitin ligase complex; Cul4B-RING E3 ubiquitin ligase complex; cytoskeleton; nucleus; nucleoplasm; cytoplasm; cytosol; Cul4-RING E3 ubiquitin ligase complex;
Biological process	ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein monoubiquitination; regulation of cell cycle; DNA replication; protein ubiquitination; response to UV; translesion synthesis; post-translational protein modification; cellular response to DNA damage stimulus; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of protein catabolic process; mitotic G2 DNA damage checkpoint signaling; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	51514
	76843
	ENSG00000143476
	ENSMUSG00000037474
	Q9NZJ0
	Q3TLR7
	NM_001286229; NM_001286230; NM_016448
	NM_029766; NM_001305233
	NP_001273158; NP_001273159; NP_057532
	NP_001292162; NP_084042
	Wikidata
View/Edit Human	View/Edit Mouse

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.^[5]^[6]

Interactions

DTL (gene) has been shown to interact with P21.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143476 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037474 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.17083-91&rft.date=2001-05&rft_id=info:doi/10.1074/jbc.M010802200&rft_id=info:pmid/11278750&rft.aulast=Cheung&rft.aufirst=WM&rft.au=Chu, AH&rft.au=Chu, PW&rft.au=Ip, NY&rft_id=https://doi.org/10.1074%2Fjbc.M010802200&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">
^ "Entrez Gene: DTL denticleless homolog (Drosophila)".
^ Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.2496-506&rft.date=2008-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546691#id-name=PMC&rft_id=info:pmid/18794347&rft_id=info:doi/10.1101/gad.1676108&rft.aulast=Abbas&rft.aufirst=T&rft.au=Sivaprasad, U&rft.au=Terai, K&rft.au=Amador, V&rft.au=Pagano, M&rft.au=Dutta, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546691&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">

Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes". Cell Cycle. 5 (15): 1719–29. doi:10.4161/cc.5.15.3150. PMID 16861890.1719-29&rft.date=2007&rft_id=info:doi/10.4161/cc.5.15.3150&rft_id=info:pmid/16861890&rft.aulast=Banks&rft.aufirst=D&rft.au=Wu, M&rft.au=Higa, LA&rft.au=Gavrilova, N&rft.au=Quan, J&rft.au=Ye, T&rft.au=Kobayashi, R&rft.au=Sun, H&rft.au=Zhang, H&rft_id=https://doi.org/10.4161%2Fcc.5.15.3150&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">
Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage". Cell Cycle. 5 (15): 1675–80. doi:10.4161/cc.5.15.3149. PMID 16861906.1675-80&rft.date=2007&rft_id=info:doi/10.4161/cc.5.15.3149&rft_id=info:pmid/16861906&rft.aulast=Higa&rft.aufirst=LA&rft.au=Banks, D&rft.au=Wu, M&rft.au=Kobayashi, R&rft.au=Sun, H&rft.au=Zhang, H&rft_id=https://doi.org/10.4161%2Fcc.5.15.3149&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">
Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1". Mol. Cell. 23 (5): 709–21. doi:10.1016/j.molcel.2006.08.010. PMID 16949367.709-21&rft.date=2006&rft_id=info:doi/10.1016/j.molcel.2006.08.010&rft_id=info:pmid/16949367&rft.aulast=Jin&rft.aufirst=J&rft.au=Arias, EE&rft.au=Chen, J&rft.au=Harper, JW&rft.au=Walter, JC&rft_id=https://doi.org/10.1016%2Fj.molcel.2006.08.010&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.1285-92&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:14294292#id-name=S2CID&rft_id=info:pmid/16964243&rft_id=info:doi/10.1038/nbt1240&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Villén, J&rft.au=Gerber, SA&rft.au=Rush, J&rft.au=Gygi, SP&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">
Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. hdl:10397/34293. PMID 17041588. S2CID 22180568.1277-83&rft.date=2006&rft_id=info:hdl/10397/34293&rft_id=https://api.semanticscholar.org/CorpusID:22180568#id-name=S2CID&rft_id=info:pmid/17041588&rft_id=info:doi/10.1038/ncb1490&rft.aulast=Higa&rft.aufirst=LA&rft.au=Wu, M&rft.au=Ye, T&rft.au=Kobayashi, R&rft.au=Sun, H&rft.au=Zhang, H&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">
Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA (2006). "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint". Genes Dev. 20 (22): 3117–29. doi:10.1101/gad.1482106. PMC 1635147. PMID 17085480.3117-29&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635147#id-name=PMC&rft_id=info:pmid/17085480&rft_id=info:doi/10.1101/gad.1482106&rft.aulast=Sansam&rft.aufirst=CL&rft.au=Shepard, JL&rft.au=Lai, K&rft.au=Ianari, A&rft.au=Danielian, PS&rft.au=Amsterdam, A&rft.au=Hopkins, N&rft.au=Lees, JA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635147&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">
Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC (2007). "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma" (PDF). Cell Cycle. 5 (22): 2676–87. doi:10.4161/cc.5.22.3500. PMID 17106265.2676-87&rft.date=2007&rft_id=info:doi/10.4161/cc.5.22.3500&rft_id=info:pmid/17106265&rft.aulast=Pan&rft.aufirst=HW&rft.au=Chou, HY&rft.au=Liu, SH&rft.au=Peng, SY&rft.au=Liu, CL&rft.au=Hsu, HC&rft_id=http://ntur.lib.ntu.edu.tw/news/agent_contract.pdf&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143476 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037474 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11278750-5] Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.17083-91&rft.date=2001-05&rft_id=info:doi/10.1074/jbc.M010802200&rft_id=info:pmid/11278750&rft.aulast=Cheung&rft.aufirst=WM&rft.au=Chu, AH&rft.au=Chu, PW&rft.au=Ip, NY&rft_id=https://doi.org/10.1074%2Fjbc.M010802200&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">

[entrez-6] "Entrez Gene: DTL denticleless homolog (Drosophila)".

[pmid18794347-7] Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.2496-506&rft.date=2008-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546691#id-name=PMC&rft_id=info:pmid/18794347&rft_id=info:doi/10.1101/gad.1676108&rft.aulast=Abbas&rft.aufirst=T&rft.au=Sivaprasad, U&rft.au=Terai, K&rft.au=Amador, V&rft.au=Pagano, M&rft.au=Dutta, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546691&rfr_id=info:sid/en.wikipedia.org:DTL (gene)" class="Z3988">

[5]

[6]

[1]

[2]

[3]

[4]

[7]

DTL (gene)

Interactions

References

Further reading