Wikipedia

DHRS1

Dehydrogenase/reductase SDR family member 1, also known as Short chain dehydrogenase/reductase family 19C member 1 is an enzyme that in humans is encoded by the DHRS1 gene located on chromosome 14.[5][6][7]

DHRS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDHRS1, SDR19C1, dehydrogenase/reductase (SDR family) member 1, dehydrogenase/reductase 1
External IDsOMIM: 610410; MGI: 1196314; HomoloGene: 41696; GeneCards: DHRS1; OMA:DHRS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

115817

52585

Ensembl

ENSG00000157379
ENSG00000284868

ENSMUSG00000002332

UniProt

Q96LJ7

Q99L04

RefSeq (mRNA)

NM_001136050
NM_138452

NM_026819

RefSeq (protein)

NP_001129522
NP_612461

NP_081095

Location (UCSC)Chr 14: 24.29 – 24.3 MbChr 14: 55.98 – 55.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Structure

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The DHRS1 gene is located on the chromosome 14q21.3 region and contains 9 exons. It encodes a 314-amino-acid, 33-kDa protein that is thought to be located to the endoplasmic reticulum and the mitochondrial inner membrane inside the cell.

Function

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The DHRS1 protein is thought to have oxidoreductase activity based on sequence similarity and conserved catalytic sites with other short-chain oxidoreductase enzymes. The enzyme is found to be expressed in the fetal brain.[8]

Interactions

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The DHRS1 protein is thought to interact with the protein phospholipid scrambase 1 (PLSCR1).[9]

References

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  1. ^ a b c ENSG00000284868 GRCh38: Ensembl release 89: ENSG00000157379, ENSG00000284868 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002332 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, et al. (Aug 2002). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain". Mol Biol Rep. 28 (4): 193–8. doi:10.1023/A:1015722001960. PMID 12153138. S2CID 29552121.193-8&rft.date=2002-08&rft_id=https://api.semanticscholar.org/CorpusID:29552121#id-name=S2CID&rft_id=info:pmid/12153138&rft_id=info:doi/10.1023/A:1015722001960&rft.aulast=Wu&rft.aufirst=Q&rft.au=Xu, M&rft.au=Cheng, C&rft.au=Zhou, Z&rft.au=Huang, Y&rft.au=Zhao, W&rft.au=Zeng, L&rft.au=Xu, J&rft.au=Fu, X&rft.au=Ying, K&rft.au=Xie, Y&rft.au=Mao, Y&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  6. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.1–3&rft.pages=94-8&rft.date=2009-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896744#id-name=PMC&rft_id=info:pmid/19027726&rft_id=info:doi/10.1016/j.cbi.2008.10.040&rft_id=info:bibcode/2009CBI...178...94P&rft.aulast=Persson&rft.aufirst=B&rft.au=Kallberg, Y&rft.au=Bray, JE&rft.au=Bruford, E&rft.au=Dellaporta, SL&rft.au=Favia, AD&rft.au=Duarte, RG&rft.au=Jornvall, H&rft.au=Kavanagh, KL&rft.au=Kedishvili, N&rft.au=Kisiela, M&rft.au=Maser, E&rft.au=Mindnich, R&rft.au=Orchard, S&rft.au=Penning, TM&rft.au=Thornton, JM&rft.au=Adamski, J&rft.au=Oppermann, U&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896744&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  7. ^ "Entrez Gene: DHRS1 dehydrogenase/reductase (SDR family) member 1".
  8. ^ Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, et al. (2001). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain". Mol. Biol. Rep. 28 (4): 193–8. doi:10.1023/A:1015722001960. PMID 12153138. S2CID 29552121.193-8&rft.date=2001&rft_id=https://api.semanticscholar.org/CorpusID:29552121#id-name=S2CID&rft_id=info:pmid/12153138&rft_id=info:doi/10.1023/A:1015722001960&rft.aulast=Wu&rft.aufirst=Q&rft.au=Xu, M&rft.au=Cheng, C&rft.au=Zhou, Z&rft.au=Huang, Y&rft.au=Zhao, W&rft.au=Zeng, L&rft.au=Xu, J&rft.au=Fu, X&rft.au=Ying, K&rft.au=Xie, Y&rft.au=Mao, Y&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  9. ^ "IntAct Portal".

Further reading

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  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.1788-95&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948#id-name=PMC&rft_id=info:pmid/11076863&rft_id=info:doi/10.1101/gr.143000&rft.aulast=Hartley&rft.aufirst=JL&rft.au=Temple, GF&rft.au=Brasch, MA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.422-35&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072#id-name=PMC&rft_id=info:pmid/11230166&rft_id=info:doi/10.1101/gr.GR1547R&rft.au=Wiemann S&rft.au=Weil B&rft.au=Wellenreuther R&rft.au=Gassenhuber, J&rft.au=Glassl, S&rft.au=Ansorge, W&rft.au=Böcher, M&rft.au=Blöcker, H&rft.au=Bauersachs, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.287-92&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732#id-name=PMC&rft_id=info:pmid/11256614&rft_id=info:doi/10.1093/embo-reports/kvd058&rft.au=Simpson JC&rft.au=Wellenreuther R&rft.au=Poustka A&rft.au=Pepperkok, R&rft.au=Wiemann, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.au=Strausberg RL&rft.au=Feingold EA&rft.au=Grouse LH&rft.au=Derge, JG&rft.au=Klausner, RD&rft.au=Collins, FS&rft.au=Wagner, L&rft.au=Shenmen, CM&rft.au=Schuler, GD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  • Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.au=Ota T&rft.au=Suzuki Y&rft.au=Nishikawa T&rft.au=Otsuki, Tetsuji&rft.au=Sugiyama, Tomoyasu&rft.au=Irie, Ryotaro&rft.au=Wakamatsu, Ai&rft.au=Hayashi, Koji&rft.au=Sato, Hiroyuki&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  • Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.au=Gerhard DS&rft.au=Wagner L&rft.au=Feingold EA&rft.au=Shenmen, CM&rft.au=Grouse, LH&rft.au=Schuler, G&rft.au=Klein, SL&rft.au=Old, S&rft.au=Rasooly, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.2136-44&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930#id-name=PMC&rft_id=info:pmid/15489336&rft_id=info:doi/10.1101/gr.2576704&rft.au=Wiemann S&rft.au=Arlt D&rft.au=Huber W&rft.au=Wellenreuther, R&rft.au=Schleeger, S&rft.au=Mehrle, A&rft.au=Bechtel, S&rft.au=Sauermann, M&rft.au=Korf, U&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.au=Rual JF&rft.au=Venkatesan K&rft.au=Hao T&rft.au=Hirozane-Kishikawa, Tomoko&rft.au=Dricot, Amélie&rft.au=Li, Ning&rft.au=Berriz, Gabriel F.&rft.au=Gibbons, Francis D.&rft.au=Dreze, Matija&rfr_id=info:sid/en.wikipedia.org:DHRS1" class="Z3988">
  • Mehrle A, Rosenfelder H, Schupp I, Del Val C, Arlt D, Hahne F, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


 

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