DAP (gene)

DAP
Identifiers
Aliases	DAP, death associated protein
External IDs	OMIM: 600954; MGI: 1918190; HomoloGene: 3235; GeneCards: DAP; OMA:DAP - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	10,761,234 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	31,274,487 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; stromal cell of endometrium; ; islet of Langerhans; ; gallbladder; ; right coronary artery; ; thoracic aorta; ; ascending aorta; ; left adrenal gland; ; right adrenal cortex; ; left adrenal cortex;
	Top expressed in
	transitional epithelium of urinary bladder; ; calvaria; ; gastrula; ; blood; ; pyloric antrum; ; pancreas; ; islet of Langerhans; ; left lobe of liver; ; ankle; ; body of femur;
	More reference expression data
	More reference expression data
Orthologs
	1611
	223453
	ENSG00000112977
	ENSMUSG00000039168
	P51397
	Q91XC8
	NM_004394; NM_001291963
	NM_146057
	NP_001278892; NP_004385
	NP_666169
	Wikidata
View/Edit Human	View/Edit Mouse

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene.^[5]^[6]^[7]

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112977 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039168 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.305-7&rft.date=1996-02&rft_id=info:doi/10.1006/geno.1995.1255&rft_id=info:pmid/8530096&rft.aulast=Feinstein&rft.aufirst=E&rft.au=Druck, T&rft.au=Kastury, K&rft.au=Berissi, H&rft.au=Goodart, SA&rft.au=Overhauser, J&rft.au=Kimchi, A&rft.au=Huebner, K&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">
^ Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev. 9 (1): 15–30. doi:10.1101/gad.9.1.15. PMID 7828849.15-30&rft.date=1995-02&rft_id=info:doi/10.1101/gad.9.1.15&rft_id=info:pmid/7828849&rft.aulast=Deiss&rft.aufirst=LP&rft.au=Feinstein, E&rft.au=Berissi, H&rft.au=Cohen, O&rft.au=Kimchi, A&rft_id=https://doi.org/10.1101%2Fgad.9.1.15&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">
^ ^a ^b "Entrez Gene: DAP death-associated protein".

Levy-Strumpf N, Kimchi A (1999). "Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions". Oncogene. 17 (25): 3331–40. doi:10.1038/sj.onc.1202588. PMID 9916995.3331-40&rft.date=1999&rft_id=info:doi/10.1038/sj.onc.1202588&rft_id=info:pmid/9916995&rft.aulast=Levy-Strumpf&rft.aufirst=N&rft.au=Kimchi, A&rft_id=https://doi.org/10.1038%2Fsj.onc.1202588&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.635-48&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:7827573#id-name=S2CID&rft_id=info:pmid/17081983&rft_id=info:doi/10.1016/j.cell.2006.09.026&rft.au=Olsen JV&rft.au=Blagoev B&rft.au=Gnad F&rft.au=Macek, Boris&rft.au=Kumar, Chanchal&rft.au=Mortensen, Peter&rft.au=Mann, Matthias&rft_id=https://doi.org/10.1016%2Fj.cell.2006.09.026&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">
Zougman A, Wiśniewski JR (2006). "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins". J. Proteome Res. 5 (4): 925–34. doi:10.1021/pr050415p. PMID 16602700.925-34&rft.date=2006&rft_id=info:doi/10.1021/pr050415p&rft_id=info:pmid/16602700&rft.aulast=Zougman&rft.aufirst=A&rft.au=Wiśniewski, JR&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.au=Gerhard DS&rft.au=Wagner L&rft.au=Feingold EA&rft.au=Shenmen, CM&rft.au=Grouse, LH&rft.au=Schuler, G&rft.au=Klein, SL&rft.au=Old, S&rft.au=Rasooly, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.1711-8&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316#id-name=PMC&rft_id=info:pmid/15342556&rft_id=info:doi/10.1101/gr.2435604&rft.au=Suzuki Y&rft.au=Yamashita R&rft.au=Shirota M&rft.au=Sakakibara, Y&rft.au=Chiba, J&rft.au=Mizushima-Sugano, J&rft.au=Nakai, K&rft.au=Sugano, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.au=Strausberg RL&rft.au=Feingold EA&rft.au=Grouse LH&rft.au=Derge, JG&rft.au=Klausner, RD&rft.au=Collins, FS&rft.au=Wagner, L&rft.au=Shenmen, CM&rft.au=Schuler, GD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112977 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039168 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530096-5] Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.305-7&rft.date=1996-02&rft_id=info:doi/10.1006/geno.1995.1255&rft_id=info:pmid/8530096&rft.aulast=Feinstein&rft.aufirst=E&rft.au=Druck, T&rft.au=Kastury, K&rft.au=Berissi, H&rft.au=Goodart, SA&rft.au=Overhauser, J&rft.au=Kimchi, A&rft.au=Huebner, K&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">

[pmid7828849-6] Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev. 9 (1): 15–30. doi:10.1101/gad.9.1.15. PMID 7828849.15-30&rft.date=1995-02&rft_id=info:doi/10.1101/gad.9.1.15&rft_id=info:pmid/7828849&rft.aulast=Deiss&rft.aufirst=LP&rft.au=Feinstein, E&rft.au=Berissi, H&rft.au=Cohen, O&rft.au=Kimchi, A&rft_id=https://doi.org/10.1101%2Fgad.9.1.15&rfr_id=info:sid/en.wikipedia.org:DAP (gene)" class="Z3988">

[entrez-7] "Entrez Gene: DAP death-associated protein".

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[6]

[7]

[1]

[2]

[3]

[4]

DAP (gene)

References

Further reading