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Xylulose 5-phosphate

(Redirected from D-xylulose-5-phosphate)

D-Xylulose 5-phosphate (D-xylulose-5-P) is an intermediate in the pentose phosphate pathway. It is a ketose sugar formed from ribulose-5-phosphate by ribulose-5-phosphate epimerase. In the non-oxidative branch of the pentose phosphate pathway, xylulose-5-phosphate acts as a donor of two-carbon ketone groups in transketolase reactions.[1]

Xylulose 5-phosphate
Names
IUPAC name
5-O-Phosphonato-D-xylulose
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
MeSH xylulose-5-phosphate
  • InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 checkY
    Key: FNZLKVNUWIIPSJ-RFZPGFLSSA-L checkY
  • [O-]P([O-])(=O)OC[C@@H](O)[C@H](O)C(=O)CO
Properties
C5H11O8P
Molar mass 230.109 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Xylulose-5-phosphate also plays a crucial role in the regulation of glycolysis through its interaction with the bifunctional enzyme PFK2/FBPase2. Specifically, it activates protein phosphatase, which then dephosphorylates PFK2/FBPase2. This inactivates the FBPase2 activity of the bifunctional enzyme and activates its PFK2 activity.[2] As a result, the production of fructose 2,6-bisphosphate increases, ultimately leading to an upregulation of glycolysis.[3]

Although previously thought of mainly as an intermediary in the pentose phosphate pathway, recent research reported that the sugar also has a role in gene expression, mainly by promoting the ChREBP transcription factor in the well-fed state.[4][5] However, more recent study showed that D-glucose-6-phosphate, rather than D-xylulose-5-phosphate, is essential for the activation of ChREBP in response to glucose.[6]

References

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  1. ^ Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, et al. (August 2015). "The return of metabolism: biochemistry and physiology of the pentose phosphate pathway". Biological Reviews of the Cambridge Philosophical Society. 90 (3): 927–963. doi:10.1111/brv.12140. PMC 4470864. PMID 25243985.927-963&rft.date=2015-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470864#id-name=PMC&rft_id=info:pmid/25243985&rft_id=info:doi/10.1111/brv.12140&rft.aulast=Stincone&rft.aufirst=A&rft.au=Prigione, A&rft.au=Cramer, T&rft.au=Wamelink, MM&rft.au=Campbell, K&rft.au=Cheung, E&rft.au=Olin-Sandoval, V&rft.au=Grüning, NM&rft.au=Krüger, A&rft.au=Tauqeer Alam, M&rft.au=Keller, MA&rft.au=Breitenbach, M&rft.au=Brindle, KM&rft.au=Rabinowitz, JD&rft.au=Ralser, M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470864&rfr_id=info:sid/en.wikipedia.org:Xylulose 5-phosphate" class="Z3988">
  2. ^ Nelson, David L.; Cox, Michael M.; Nelson, David L. (2013). Lehninger, Albert L. (ed.). Lehninger principles of biochemistry (6th ed.). Basingstoke: Macmillan Higher Education. p. 606. ISBN 978-1-4292-3414-6.
  3. ^ Uyeda K (June 2021). "Short- and Long-Term Adaptation to Altered Levels of Glucose: Fifty Years of Scientific Adventure". Annual Review of Biochemistry. 90 (1): 31–55. doi:10.1146/annurev-biochem-070820-125228. PMID 34153217.31-55&rft.date=2021-06&rft_id=info:doi/10.1146/annurev-biochem-070820-125228&rft_id=info:pmid/34153217&rft.aulast=Uyeda&rft.aufirst=K&rft_id=https://doi.org/10.1146%2Fannurev-biochem-070820-125228&rfr_id=info:sid/en.wikipedia.org:Xylulose 5-phosphate" class="Z3988">
  4. ^ Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K (April 2003). "Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver". Proceedings of the National Academy of Sciences of the United States of America. 100 (9): 5107–5112. Bibcode:2003PNAS..100.5107K. doi:10.1073/pnas.0730817100. PMC 154306. PMID 12684532.5107-5112&rft.date=2003-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154306#id-name=PMC&rft_id=info:pmid/12684532&rft_id=info:doi/10.1073/pnas.0730817100&rft_id=info:bibcode/2003PNAS..100.5107K&rft.aulast=Kabashima&rft.aufirst=T&rft.au=Kawaguchi, T&rft.au=Wadzinski, BE&rft.au=Uyeda, K&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154306&rfr_id=info:sid/en.wikipedia.org:Xylulose 5-phosphate" class="Z3988">
  5. ^ Iizuka K, Horikawa Y (August 2008). "ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome". Endocrine Journal. 55 (4): 617–624. doi:10.1507/endocrj.k07e-110. PMID 18490833.617-624&rft.date=2008-08&rft_id=info:doi/10.1507/endocrj.k07e-110&rft_id=info:pmid/18490833&rft.aulast=Iizuka&rft.aufirst=K&rft.au=Horikawa, Y&rft_id=https://doi.org/10.1507%2Fendocrj.k07e-110&rfr_id=info:sid/en.wikipedia.org:Xylulose 5-phosphate" class="Z3988">
  6. ^ Dentin R, Tomas-Cobos L, Foufelle F, Leopold J, Girard J, Postic C, Ferré P (January 2012). "Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver". Journal of Hepatology. 56 (1): 199–209. doi:10.1016/j.jhep.2011.07.019. PMID 21835137.199-209&rft.date=2012-01&rft_id=info:doi/10.1016/j.jhep.2011.07.019&rft_id=info:pmid/21835137&rft.aulast=Dentin&rft.aufirst=R&rft.au=Tomas-Cobos, L&rft.au=Foufelle, F&rft.au=Leopold, J&rft.au=Girard, J&rft.au=Postic, C&rft.au=Ferré, P&rfr_id=info:sid/en.wikipedia.org:Xylulose 5-phosphate" class="Z3988">
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