In enzymology, a D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) is an enzyme that catalyzes the chemical reaction
| D-threo-aldose 1-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.122 | ||||||||
| CAS no. | 9082-70-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- a D-threo-aldose NAD a D-threo-aldono-1,5-lactone NADH H
Thus, the two substrates of this enzyme are D-threo-aldose and NAD , whereas its 3 products are D-threo-aldono-1,5-lactone, NADH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is D-threo-aldose:NAD 1-oxidoreductase. Other names in common use include L-fucose dehydrogenase, (2S,3R)-aldose dehydrogenase, dehydrogenase, L-fucose, and L-fucose (D-arabinose) dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.
References
edit- Sasajima KI, Sinskey AJ (1979). "Oxidation of L-glucose by a Pseudomonad". Biochim. Biophys. Acta. 571 (1): 120–6. doi:10.1016/0005-2744(79)90232-8. PMID 40609.120-6&rft.date=1979&rft_id=info:doi/10.1016/0005-2744(79)90232-8&rft_id=info:pmid/40609&rft.aulast=Sasajima&rft.aufirst=KI&rft.au=Sinskey, AJ&rfr_id=info:sid/en.wikipedia.org:D-threo-aldose 1-dehydrogenase" class="Z3988">
- Schachter H, Sarney J, McGuire EJ, Roseman S (1969). "Isolation of diphosphopyridine nucleotide-dependent L-fucose dehydrogenase from pork liver". J. Biol. Chem. 244 (17): 4785–92. PMID 4309152.4785-92&rft.date=1969&rft_id=info:pmid/4309152&rft.aulast=Schachter&rft.aufirst=H&rft.au=Sarney, J&rft.au=McGuire, EJ&rft.au=Roseman, S&rfr_id=info:sid/en.wikipedia.org:D-threo-aldose 1-dehydrogenase" class="Z3988">
