Cysteic acid also known as 3-sulfo-l-alanine is the organic compound with the formula HO3SCH2CH(NH2)CO2H. It is often referred to as cysteate, which near neutral pH takes the form −O3SCH2CH(NH3 )CO2−.
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IUPAC name
(R)-2-Amino-3-sulfopropanoic acid
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Other names
3-Sulfo-l-alanine
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Identifiers | |
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DrugBank | |
ECHA InfoCard | 100.265.539 |
EC Number |
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MeSH | Cysteic acid |
PubChem CID
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CompTox Dashboard (EPA)
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Properties[1] | |
C3H7NO5S | |
Molar mass | 169.15 g·mol−1 |
Appearance | White crystals or powder |
Melting point | Decomposes around 272 °C |
Soluble | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It is an amino acid generated by oxidation of cysteine, whereby a thiol group is fully oxidized to a sulfonic acid/sulfonate group. It is further metabolized via 3-sulfolactate, which converts to pyruvate and sulfite/bisulfite. The enzyme L-cysteate sulfo-lyase catalyzes this conversion. Cysteate is a biosynthetic precursor to taurine in microalgae.[2] By contrast, most taurine in animals is made from cysteine sulfinate.[3]
References
edit- ^ Weast, Robert C., ed. (1981). CRC Handbook of Chemistry and Physics (62nd ed.). Boca Raton, Florida: CRC Press. p. C259. ISBN 0-8493-0462-8..
- ^ Tevatia, Rahul; Allen, James; Rudrappa, Deepak; White, Derrick; Clemente, Thomas E.; Cerutti, Heriberto; Demirel, Yaşar; Blum, Paul (2015-05-01). "The taurine biosynthetic pathway of microalgae". Algal Research. 9: 21–26. doi:10.1016/j.algal.2015.02.012. ISSN 2211-9264.21-26&rft.date=2015-05-01&rft_id=info:doi/10.1016/j.algal.2015.02.012&rft.issn=2211-9264&rft.aulast=Tevatia&rft.aufirst=Rahul&rft.au=Allen, James&rft.au=Rudrappa, Deepak&rft.au=White, Derrick&rft.au=Clemente, Thomas E.&rft.au=Cerutti, Heriberto&rft.au=Demirel, Yaşar&rft.au=Blum, Paul&rft_id=https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1167&context=plantscifacpub&rfr_id=info:sid/en.wikipedia.org:Cysteic acid" class="Z3988">
- ^ Cook, Alasdair M.; Denger, Karin; Smits, Theo H. M. (2006). "Dissimilation of C3-Sulfonates". Archives of Microbiology. 185 (2): 83–90. doi:10.1007/s00203-005-0069-1. PMID 16341843. S2CID 28030645.83-90&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:28030645#id-name=S2CID&rft_id=info:pmid/16341843&rft_id=info:doi/10.1007/s00203-005-0069-1&rft.au=Cook, Alasdair M.&rft.au=Denger, Karin&rft.au=Smits, Theo H. M.&rft_id=http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-67394&rfr_id=info:sid/en.wikipedia.org:Cysteic acid" class="Z3988">