Clofenetamine

Clofenetamine
Clinical data
Other names	Phenoxethamine; Keithon
Drug class	Tranquilizer; Antihistamine; Anticholinergic; Antiparkinsonian agent
Identifiers
	IUPAC name 2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-diethylethanamine;
CAS Number	511-46-6 ; 2019-16-1 (hydrochloride);
PubChem CID	71812;
ChemSpider	64836;
UNII	5YH9CQF0FP;
ChEMBL	ChEMBL2110777;
CompTox Dashboard (EPA)	DTXSID20862081 ;
Chemical and physical data
Formula	C20H26ClNO
Molar mass	331.88 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)CCOC(C)(C1=CC=CC=C1)C2=CC=C(C=C2)Cl;
	InChI InChI=1S/C20H26ClNO/c1-4-22(5-2)15-16-23-20(3,17-9-7-6-8-10-17)18-11-13-19(21)14-12-18/h6-14H,4-5,15-16H2,1-3H3; Key:IKFQEQVEOQNTRJ-UHFFFAOYSA-N;

Clofenetamine (INNTooltip International Nonproprietary Name), also known as phenoxethamine or as Keithon, is a drug described as a tranquilizer, antihistamine, anticholinergic, and antiparkinsonian agent.^[1]^[2] It is a derivative of diphenhydramine and is closely structurally related to mephenhydramine, chlorphenoxamine, and embramine, among other drugs.^[2] Clofenetamine was discovered by Searle in the 1940s and was first described in the literature by 1956.^[3]^[1]

References

^ ^a ^b Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 295. ISBN 978-1-4757-2085-3. Retrieved 17 October 2024.
^ ^a ^b Ariëns EJ (2013). Drug Design: Medicinal Chemistry: A Series of Monographs. Vol. 6. Academic Press. pp. 12–13. ISBN 978-1-4832-1608-9. Retrieved 17 October 2024.12-13&rft.pub=Academic Press&rft.date=2013&rft.isbn=978-1-4832-1608-9&rft.aulast=Ariëns&rft.aufirst=EJ&rft_id=https://books.google.com/books?id=PQwlBQAAQBAJ&pg=PA12&rfr_id=info:sid/en.wikipedia.org:Clofenetamine" class="Z3988">
^ "CLOFENETAMINE". Inxight Drugs. National Center for Advancing Translational Sciences (NCATS), U.S National Institutes of Health. Retrieved 17 October 2024. Clofenetamine is a haloxanthine antihistamine compound discovered by Searle & Co in the 1940s.