Cirazoline is a full agonist at the α1A adrenergic receptor, a partial agonist at both the α1B and α1D adrenergic receptors,[1] and a nonselective antagonist to the α2 adrenergic receptor.[2] It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.[2]

Cirazoline
Names
Preferred IUPAC name
2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
MeSH Cirazoline
UNII
  • InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15) checkY
    Key: YAORIDZYZDUZCM-UHFFFAOYSA-N checkY
  • InChI=1/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
    Key: YAORIDZYZDUZCM-UHFFFAOYAV
  • O(c1c(cccc1)C2CC2)CC/3=N/CCN\3
Properties
C13H16N2O
Molar mass 216.284 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1 adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.[3] Administration of cirazoline also seemed to present impairment in the spatial memory of monkeys through the activation of the same receptors that showed decreased food intake in rats.[4][5] However, in preliminary studies, through stimulation of α2 adrenoceptors, working memory is comparatively improved.[4]

References

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  1. ^ Horie, K; Obika, K; Foglar, R. (1995). "Selectivity of the imidazoline α-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned α1-adrenoceptor subtypes". British Journal of Pharmacology. 116 (1): 1611–8. doi:10.1111/j.1476-5381.1995.tb16381.x. PMC 1908909. PMID 8564227.1611-8&rft.date=1995&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908909#id-name=PMC&rft_id=info:pmid/8564227&rft_id=info:doi/10.1111/j.1476-5381.1995.tb16381.x&rft.au=Horie, K&rft.au=Obika, K&rft.au=Foglar, R.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908909&rfr_id=info:sid/en.wikipedia.org:Cirazoline" class="Z3988">
  2. ^ a b Ruffolo, R. R. Jr.; Waddell, J. E. (1982). "Receptor interactions of imidazolines. IX. Cirazoline is an α1 adrenergic agonist and an α2 adrenergic antagonist". Journal of Pharmacology and Experimental Therapeutics. 222 (1): 29–36. PMID 6123592.29-36&rft.date=1982&rft_id=info:pmid/6123592&rft.au=Ruffolo, R. R. Jr.&rft.au=Waddell, J. E.&rfr_id=info:sid/en.wikipedia.org:Cirazoline" class="Z3988">
  3. ^ Davies, B. T.; Wellman, P. J. (1992). "Effects on ingestive behavior in rats of the α1-adrenoceptor agonist cirazoline". European Journal of Pharmacology. 210 (1): 11–16. doi:10.1016/0014-2999(92)90645-K. PMID 1350985.11-16&rft.date=1992&rft_id=info:doi/10.1016/0014-2999(92)90645-K&rft_id=info:pmid/1350985&rft.au=Davies, B. T.&rft.au=Wellman, P. J.&rfr_id=info:sid/en.wikipedia.org:Cirazoline" class="Z3988">
  4. ^ a b Arnsten, A.F.T.; Jentsch, J.D. (September 1997). "The Alpha-1 Adrenergic Agonist, Cirazoline, Impairs Spatial Working Memory Performance in Aged Monkeys". Pharmacology Biochemistry and Behavior. 58 (1): 55–59. doi:10.1016/s0091-3057(96)00477-7. ISSN 0091-3057. PMID 9264070. S2CID 20663570.55-59&rft.date=1997-09&rft.issn=0091-3057&rft_id=https://api.semanticscholar.org/CorpusID:20663570#id-name=S2CID&rft_id=info:pmid/9264070&rft_id=info:doi/10.1016/s0091-3057(96)00477-7&rft.aulast=Arnsten&rft.aufirst=A.F.T.&rft.au=Jentsch, J.D.&rft_id=https://doi.org/10.1016%2Fs0091-3057%2896%2900477-7&rfr_id=info:sid/en.wikipedia.org:Cirazoline" class="Z3988">
  5. ^ Imbery, Irdmusa, Speidell, Streer, Griffin, Ted E., Mitra S., Andrew P., Mark S., John D. (15 December 2007). "The effects of Cirazoline, an alpha-1 adrenoreceptor agonist, on the firing rates of thermally classified anterior hypothalamic neurons in rat brain slices". Brain Research. 1193: 93–101. doi:10.1016/j.brainres.2007.12.016. PMC 2268753. PMID 18184607.93-101&rft.date=2007-12-15&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268753#id-name=PMC&rft_id=info:pmid/18184607&rft_id=info:doi/10.1016/j.brainres.2007.12.016&rft.aulast=Imbery, Irdmusa, Speidell, Streer, Griffin&rft.aufirst=Ted E., Mitra S., Andrew P., Mark S., John D.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268753&rfr_id=info:sid/en.wikipedia.org:Cirazoline" class="Z3988">{{cite journal}}: CS1 maint: multiple names: authors list (link)