Ciclotizolam

Ciclotizolam
Clinical data
ATC code	none;
Legal status
Legal status	CA: Schedule IV;
Identifiers
	IUPAC name 8-bromo-6-(o-chlorophenyl)-1-cyclohexyl-4H-5-triazolo(3,4-c)thieno(2,4-e)-1,4-diazepine;
CAS Number	58765-21-2 ;
PubChem CID	71949;
ChemSpider	64956 ;
UNII	JK517QTN4Q;
ChEMBL	ChEMBL2105986 ;
CompTox Dashboard (EPA)	DTXSID40866708 ;
Chemical and physical data
Formula	C20H18BrClN4S
Molar mass	461.81 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc5ccccc5C/2=N/Cc1nnc(n1c3sc(Br)cc\23)C4CCCCC4;
	InChI InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2 ; Key:ZOSHXIXUCKESEG-UHFFFAOYSA-N ;
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Ciclotizolam^[1] (WE-973) is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABA_A receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.^[2]^[3]

References

^ DE Patent 2445430
^ Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P (February 1985). "Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines')". European Journal of Pharmacology. 109 (1): 19–31. doi:10.1016/0014-2999(85)90535-7. PMID 2986988.19-31&rft.date=1985-02&rft_id=info:doi/10.1016/0014-2999(85)90535-7&rft_id=info:pmid/2986988&rft.aulast=Weber&rft.aufirst=KH&rft.au=Kuhn, FJ&rft.au=Böke-Kuhn, K&rft.au=Lehr, E&rft.au=Danneberg, PB&rft.au=Hommer, D&rft.au=Paul, SM&rft.au=Skolnick, P&rfr_id=info:sid/en.wikipedia.org:Ciclotizolam" class="Z3988">
^ Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI (1989). "Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles". Life Sciences. 45 (4): 349–58. doi:10.1016/0024-3205(89)90145-8. PMID 2569655.349-58&rft.date=1989&rft_id=info:doi/10.1016/0024-3205(89)90145-8&rft_id=info:pmid/2569655&rft.aulast=Ikeda&rft.aufirst=M&rft.au=Weber, KH&rft.au=Bechtel, WD&rft.au=Malatynska, E&rft.au=Yamamura, HI&rfr_id=info:sid/en.wikipedia.org:Ciclotizolam" class="Z3988">

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Clinical data


ATC code	none
Legal status
Legal status	CA: Schedule IV
Identifiers
IUPAC name 8-bromo-6-(o-chlorophenyl)-1-cyclohexyl-4H-5-triazolo(3,4-c)thieno(2,4-e)-1,4-diazepine
CAS Number	58765-21-2^Y
PubChem CID	71949
ChemSpider	64956^Y
UNII	JK517QTN4Q
ChEMBL	ChEMBL2105986^N
CompTox Dashboard (EPA)	DTXSID40866708
Chemical and physical data
Formula	C₂₀H₁₈BrClN₄S
Molar mass	461.81 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc5ccccc5C/2=N/Cc1nnc(n1c3sc(Br)cc\23)C4CCCCC4
InChI InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2^Y Key:ZOSHXIXUCKESEG-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)