Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.[1]
| caspase 4, apoptosis-related cysteine peptidase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CASP4 | ||||||
| Alt. symbols | ICE(rel)II, ICH-2, TX | ||||||
| NCBI gene | 837 | ||||||
| HGNC | 1505 | ||||||
| OMIM | 602664 | ||||||
| RefSeq | NM_001225 | ||||||
| UniProt | P49662 | ||||||
| Other data | |||||||
| EC number | 3.4.22.57 | ||||||
| Locus | Chr. 11 q22.2-q22.3 | ||||||
| |||||||
The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme.[2]
See also
editReferences
edit- ^ Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi:10.1038/sj.cdd.4402038. PMID 16977329.10-22&rft.date=2007&rft_id=info:doi/10.1038/sj.cdd.4402038&rft_id=info:pmid/16977329&rft.aulast=Martinon&rft.aufirst=F&rft.au=Tschopp, J&rft_id=https://doi.org/10.1038%2Fsj.cdd.4402038&rfr_id=info:sid/en.wikipedia.org:Caspase 4" class="Z3988">
- ^ Smith C, Soti S, Jones Torey A, Nakagawa A, Xue D, and Yin H (2017). "NSAIDs are Caspase Inhibitors". Cell Chem Biol. 24 (3): 281–292. doi:10.1016/j.chembiol.2017.02.003. PMC 5357154. PMID 28238723.281-292&rft.date=2017&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357154#id-name=PMC&rft_id=info:pmid/28238723&rft_id=info:doi/10.1016/j.chembiol.2017.02.003&rft.aulast=Smith&rft.aufirst=C&rft.au=Soti, S&rft.au=Jones Torey, A&rft.au=Nakagawa, A&rft.au=Xue, D&rft.au=and Yin, H&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357154&rfr_id=info:sid/en.wikipedia.org:Caspase 4" class="Z3988">
External links
edit- The MEROPS online database for peptidases and their inhibitors: C14.007[permanent dead link]
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