Rootletin, also known as ciliary rootlet coiled-coil protein (CROCC) is a protein in humans that is encoded by the CROCC gene.[5][6][7] Rootletin is a component of the ciliary rootlet and, together with CEP68 and CEP250, is required for centrosome cohesion.[8]
| Rootletin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Rootletin | ||||||||
| Pfam | PF15035 | ||||||||
| |||||||||
Rootletin is an important protein in the ciliary rootlet, particularly for the structure and is considered important protein in mitosis as a centrosome linker.
Function
editThis protein forms part of the ciliary rootlet structure. It also contributes to the centrosome cohesion before mitosis.[9] Expression of rootletin leads to the formation of fibrous protein.
Structure
editThis protein is part of the structure of a ciliary rootlet. This cytoskeletal-like structure starts from the basal body at one end of the cilium and extends towards the nucleus. Its molecular structure consists of a globular head domain and a tail domain made up of coiled-coil structures.[5]
Protein interactions
editA large coiled-coil protein, C-Nap1, is a docking site for the fibrous tether to proximal ends of centrioles which Rootletin physically interacts with. Furthermore, Rootletin is phosphorylated by Nek2 kinase.[10]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000058453 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040860 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T (Nov 2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". J Cell Biol. 159 (3): 431–40. doi:10.1083/jcb.200207153. PMC 2173070. PMID 12427867.431-40&rft.date=2002-11&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173070#id-name=PMC&rft_id=info:pmid/12427867&rft_id=info:doi/10.1083/jcb.200207153&rft.aulast=Yang&rft.aufirst=J&rft.au=Liu, X&rft.au=Yue, G&rft.au=Adamian, M&rft.au=Bulgakov, O&rft.au=Li, T&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173070&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
- ^ McClintock TS, Glasser CE, Bose SC, Bergman DA (Jan 2008). "Tissue expression patterns identify mouse cilia genes". Physiol Genomics. 32 (2): 198–206. doi:10.1152/physiolgenomics.00128.2007. PMID 17971504.198-206&rft.date=2008-01&rft_id=info:doi/10.1152/physiolgenomics.00128.2007&rft_id=info:pmid/17971504&rft.aulast=McClintock&rft.aufirst=TS&rft.au=Glasser, CE&rft.au=Bose, SC&rft.au=Bergman, DA&rft_id=https://uknowledge.uky.edu/context/physiology_data/article/1002/type/native/viewcontent&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
- ^ "Entrez Gene: CROCC ciliary rootlet coiled-coil, rootletin".
- ^ Graser S, Stierhof YD, Nigg EA (December 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". J. Cell Sci. 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID 18042621.4321-31&rft.date=2007-12&rft_id=info:doi/10.1242/jcs.020248&rft_id=info:pmid/18042621&rft.aulast=Graser&rft.aufirst=S&rft.au=Stierhof, YD&rft.au=Nigg, EA&rft_id=https://doi.org/10.1242%2Fjcs.020248&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
- ^ Bahe S, Stierhof YD, Wilkinson CJ, Leiss F, Nigg EA (October 2005). "Rootletin forms centriole-associated filaments and functions in centrosome cohesion". J. Cell Biol. 171 (1): 27–33. doi:10.1083/jcb.200504107. PMC 2171225. PMID 16203858.27-33&rft.date=2005-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171225#id-name=PMC&rft_id=info:pmid/16203858&rft_id=info:doi/10.1083/jcb.200504107&rft.aulast=Bahe&rft.aufirst=S&rft.au=Stierhof, YD&rft.au=Wilkinson, CJ&rft.au=Leiss, F&rft.au=Nigg, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171225&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
- ^ Lim HH, Zhang T, Surana U (July 2009). "Regulation of centrosome separation in yeast and vertebrates: common threads". Trends Cell Biol. 19 (7): 325–33. doi:10.1016/j.tcb.2009.03.008. PMID 19576775.325-33&rft.date=2009-07&rft_id=info:doi/10.1016/j.tcb.2009.03.008&rft_id=info:pmid/19576775&rft.aulast=Lim&rft.aufirst=HH&rft.au=Zhang, T&rft.au=Surana, U&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
Further reading
edit- Ching YP, Chan SF, Jeang KT, Jin DY (2006). "The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication". Nat. Cell Biol. 8 (7): 717–24. doi:10.1038/ncb1432. hdl:10722/54244. PMID 16767081. S2CID 10140583.717-24&rft.date=2006&rft_id=info:hdl/10722/54244&rft_id=https://api.semanticscholar.org/CorpusID:10140583#id-name=S2CID&rft_id=info:pmid/16767081&rft_id=info:doi/10.1038/ncb1432&rft.aulast=Ching&rft.aufirst=YP&rft.au=Chan, SF&rft.au=Jeang, KT&rft.au=Jin, DY&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.315-21&rft.date=2006&rft_id=info:pmid/16710414&rft_id=info:doi/10.1038/nature04727&rft_id=info:bibcode/2006Natur.441..315G&rft.aulast=Gregory&rft.aufirst=SG&rft.au=Barlow, KF&rft.au=McLay, KE&rft_id=https://doi.org/10.1038%2Fnature04727&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
- Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.570-4&rft.date=2003&rft_id=info:doi/10.1038/nature02166&rft_id=https://api.semanticscholar.org/CorpusID:4427303#id-name=S2CID&rft_id=info:pmid/14654843&rft_id=info:bibcode/2003Natur.426..570A&rft.aulast=Andersen&rft.aufirst=JS&rft.au=Wilkinson, CJ&rft.au=Mayor, T&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
- Behrends U, Schneider I, Rössler S, et al. (2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer. 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201.244-51&rft.date=2003&rft_id=info:doi/10.1002/ijc.11208&rft_id=info:pmid/12800201&rft.aulast=Behrends&rft.aufirst=U&rft.au=Schneider, I&rft.au=Rössler, S&rft_id=https://doi.org/10.1002%2Fijc.11208&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">
- Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.345-9&rft.date=1998&rft_id=info:doi/10.1093/dnares/4.5.345&rft_id=info:pmid/9455484&rft.aulast=Seki&rft.aufirst=N&rft.au=Ohira, M&rft.au=Nagase, T&rft_id=https://doi.org/10.1093%2Fdnares%2F4.5.345&rfr_id=info:sid/en.wikipedia.org:Rootletin" class="Z3988">