CRIP1

CRIP1
Identifiers
Aliases	CRIP1, CRHP, CRIP, CRP-1, CRP1, cysteine rich protein 1
External IDs	OMIM: 123875; MGI: 88501; HomoloGene: 37465; GeneCards: CRIP1; OMA:CRIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	105,488,947 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	113,117,499 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; granulocyte; ; left coronary artery; ; popliteal artery; ; tibial arteries; ; olfactory zone of nasal mucosa; ; right uterine tube; ; ascending aorta; ; Descending thoracic aorta; ; duodenum;
	Top expressed in
	left colon; ; crypt of lieberkuhn of small intestine; ; duodenum; ; ankle; ; tunica media of zone of aorta; ; gastrula; ; umbilical cord; ; carotid body; ; Paneth cell; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptide binding; DNA binding, bending; metal ion binding; minor groove of adenine-thymine-rich DNA binding; zinc ion binding;
Cellular component	cytoplasm;
Biological process	regulation of gene expression; prostate gland stromal morphogenesis; cellular response to antibiotic; heart development; response to zinc ion; cell population proliferation; cellular response to UV-B; response to organic substance; immune response; intrinsic apoptotic signaling pathway in response to DNA damage;
	Sources:Amigo / QuickGO
Orthologs
	1396
	12925
	ENSG00000213145
	ENSMUSG00000006360
	P50238
	P63254
	NM_001311
	NM_007763
	NP_001302
	NP_031789
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine-rich protein 1 is a protein that in humans is encoded by the CRIP1 gene.^[5]^[6]

Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213145 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006360 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garcia-Barcelo M, Tsui SK, Chim SS, Fung KP, Lee CY, Waye MM (Apr 1998). "Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23". Genomics. 47 (3): 419–422. doi:10.1006/geno.1997.5134. PMID 9480758.419-422&rft.date=1998-04&rft_id=info:doi/10.1006/geno.1997.5134&rft_id=info:pmid/9480758&rft.aulast=Garcia-Barcelo&rft.aufirst=M&rft.au=Tsui, SK&rft.au=Chim, SS&rft.au=Fung, KP&rft.au=Lee, CY&rft.au=Waye, MM&rfr_id=info:sid/en.wikipedia.org:CRIP1" class="Z3988">
^ ^a ^b "Entrez Gene: CRIP1 cysteine-rich protein 1 (intestinal)".

External links

Human CRIP1 genome location and CRIP1 gene details page in the UCSC Genome Browser.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-2127&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.au=Gerhard DS&rft.au=Wagner L&rft.au=Feingold EA&rft.au=Shenmen, CM&rft.au=Grouse, LH&rft.au=Schuler, G&rft.au=Klein, SL&rft.au=Old, S&rft.au=Rasooly, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:CRIP1" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.40-45&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.au=Ota T&rft.au=Suzuki Y&rft.au=Nishikawa T&rft.au=Otsuki, Tetsuji&rft.au=Sugiyama, Tomoyasu&rft.au=Irie, Ryotaro&rft.au=Wakamatsu, Ai&rft.au=Hayashi, Koji&rft.au=Sato, Hiroyuki&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:CRIP1" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-16903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.au=Strausberg RL&rft.au=Feingold EA&rft.au=Grouse LH&rft.au=Derge, JG&rft.au=Klausner, RD&rft.au=Collins, FS&rft.au=Wagner, L&rft.au=Shenmen, CM&rft.au=Schuler, GD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:CRIP1" class="Z3988">
Khoo C, Blanchard RK, Sullivan VK, Cousins RJ (1997). "Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells". Protein Expr. Purif. 9 (3): 379–387. doi:10.1006/prep.1996.0709. PMID 9126610.379-387&rft.date=1997&rft_id=info:doi/10.1006/prep.1996.0709&rft_id=info:pmid/9126610&rft.aulast=Khoo&rft.aufirst=C&rft.au=Blanchard, RK&rft.au=Sullivan, VK&rft.au=Cousins, RJ&rfr_id=info:sid/en.wikipedia.org:CRIP1" class="Z3988">
Khoo C, Cousins RJ (1994). "Purification and properties of rat cysteine-rich intestinal protein". Biochem. J. 299 (2): 445–50. doi:10.1042/bj2990445. PMC 1138292. PMID 8172605.445-50&rft.date=1994&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1138292#id-name=PMC&rft_id=info:pmid/8172605&rft_id=info:doi/10.1042/bj2990445&rft.aulast=Khoo&rft.aufirst=C&rft.au=Cousins, RJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1138292&rfr_id=info:sid/en.wikipedia.org:CRIP1" class="Z3988">
Tsui SK, Yam NY, Lee CY, Waye MM (1995). "Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart". Biochem. Biophys. Res. Commun. 205 (1): 497–505. doi:10.1006/bbrc.1994.2693. PMID 7999070.497-505&rft.date=1995&rft_id=info:doi/10.1006/bbrc.1994.2693&rft_id=info:pmid/7999070&rft.aulast=Tsui&rft.aufirst=SK&rft.au=Yam, NY&rft.au=Lee, CY&rft.au=Waye, MM&rfr_id=info:sid/en.wikipedia.org:CRIP1" class="Z3988">
Hempe JM, Cousins RJ (1991). "Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9671–9674. Bibcode:1991PNAS...88.9671H. doi:10.1073/pnas.88.21.9671. PMC 52780. PMID 1946385.9671-9674&rft.date=1991&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52780#id-name=PMC&rft_id=info:pmid/1946385&rft_id=info:doi/10.1073/pnas.88.21.9671&rft_id=info:bibcode/1991PNAS...88.9671H&rft.aulast=Hempe&rft.aufirst=JM&rft.au=Cousins, RJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52780&rfr_id=info:sid/en.wikipedia.org:CRIP1" class="Z3988">

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213145 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006360 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9480758-5] Garcia-Barcelo M, Tsui SK, Chim SS, Fung KP, Lee CY, Waye MM (Apr 1998). "Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23". Genomics. 47 (3): 419–422. doi:10.1006/geno.1997.5134. PMID 9480758.419-422&rft.date=1998-04&rft_id=info:doi/10.1006/geno.1997.5134&rft_id=info:pmid/9480758&rft.aulast=Garcia-Barcelo&rft.aufirst=M&rft.au=Tsui, SK&rft.au=Chim, SS&rft.au=Fung, KP&rft.au=Lee, CY&rft.au=Waye, MM&rfr_id=info:sid/en.wikipedia.org:CRIP1" class="Z3988">

[entrez-6] "Entrez Gene: CRIP1 cysteine-rich protein 1 (intestinal)".

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CRIP1

References

External links

Further reading