CNTROB

CNTROB
Identifiers
Aliases	CNTROB, LIP8, PP1221, centrobin, centriole duplication and spindle assembly protein
External IDs	OMIM: 611425; MGI: 2443290; HomoloGene: 14205; GeneCards: CNTROB; OMA:CNTROB - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,949,920 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,323,775 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; ventricular zone; ; body of uterus; ; ganglionic eminence; ; right lung; ; upper lobe of left lung; ; pancreatic ductal cell; ; canal of the cervix; ; cardiac muscle tissue of right atrium;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; ventricular zone; ; otic vesicle; ; neural layer of retina; ; secondary oocyte; ; spermatocyte; ; zygote; ; thymus; ; primary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein domain specific binding;
Cellular component	centriole; centrosome; cytoskeleton; cytoplasm; cytosol;
Biological process	cell cycle; mitotic cytokinetic process; centrosome separation; cell division; centriole replication; regulation of cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	116840
	216846
	ENSG00000170037
	ENSMUSG00000032782
	Q8N137
	Q8CB62
NM_001037144; NM_053051; NM_001330124; NM_001353202; NM_001353203;
	NM_001353204; NM_001353205; NM_001353206; NM_001353207; NM_001353208; NM_001353209
	NM_172560
NP_001032221; NP_001317053; NP_444279; NP_001340131; NP_001340132;
	NP_001340133; NP_001340134; NP_001340135; NP_001340136; NP_001340137; NP_001340138
	NP_766148
	Wikidata
View/Edit Human	View/Edit Mouse

Centrobin is a protein that in humans is encoded by the CNTROB gene.^[5] It is a centriole-associated protein that asymmetrically localizes to the daughter centriole, and is required for centriole duplication and cytokinesis.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170037 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032782 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tchernev, V. T.; Mansfield, T. A.; Giot, L.; Kumar, A. M.; Nandabalan, K.; Li, Y.; Mishra, V. S.; Detter, J. C.; Rothberg, J. M.; Wallace, M. R.; Southwick, F. S.; Kingsmore, S. F. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.56-64&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039936#id-name=PMC&rft_id=info:pmid/11984006&rft_id=info:doi/10.1007/bf03402003&rft.aulast=Tchernev&rft.aufirst=V. T.&rft.au=Mansfield, T. A.&rft.au=Giot, L.&rft.au=Kumar, A. M.&rft.au=Nandabalan, K.&rft.au=Li, Y.&rft.au=Mishra, V. S.&rft.au=Detter, J. C.&rft.au=Rothberg, J. M.&rft.au=Wallace, M. R.&rft.au=Southwick, F. S.&rft.au=Kingsmore, S. F.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039936&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">
^ Zou, C.; Li, J.; Bai, Y.; Gunning, W.; Wazer, D.; Band, V.; Gao, Q. (2005). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". Journal of Cell Biology. 171 (3): 437–445. doi:10.1083/jcb.200506185. PMC 2171251. PMID 16275750.437-445&rft.date=2005&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171251#id-name=PMC&rft_id=info:pmid/16275750&rft_id=info:doi/10.1083/jcb.200506185&rft.aulast=Zou&rft.aufirst=C.&rft.au=Li, J.&rft.au=Bai, Y.&rft.au=Gunning, W.&rft.au=Wazer, D.&rft.au=Band, V.&rft.au=Gao, Q.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171251&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">

External links

Human CNTROB genome location and CNTROB gene details page in the UCSC Genome Browser.

Jeong Y, Lee J, Kim K, et al. (2007). "Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization". J. Cell Sci. 120 (Pt 12): 2106–16. doi:10.1242/jcs.03458. PMID 17535851.2106-16&rft.date=2007&rft_id=info:doi/10.1242/jcs.03458&rft_id=info:pmid/17535851&rft.aulast=Jeong&rft.aufirst=Y&rft.au=Lee, J&rft.au=Kim, K&rft_id=https://doi.org/10.1242%2Fjcs.03458&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.801-14&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:13709685#id-name=S2CID&rft_id=info:pmid/16713569&rft_id=info:doi/10.1016/j.cell.2006.03.032&rft.aulast=Lim&rft.aufirst=J&rft.au=Hao, T&rft.au=Shaw, C&rft_id=https://doi.org/10.1016%2Fj.cell.2006.03.032&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.15724-9&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524842#id-name=PMC&rft_id=info:pmid/15498874&rft_id=info:doi/10.1073/pnas.0404089101&rft_id=info:bibcode/2004PNAS..10115724W&rft.aulast=Wan&rft.aufirst=D&rft.au=Gong, Y&rft.au=Qin, W&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524842&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170037 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032782 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11984006-5] Tchernev, V. T.; Mansfield, T. A.; Giot, L.; Kumar, A. M.; Nandabalan, K.; Li, Y.; Mishra, V. S.; Detter, J. C.; Rothberg, J. M.; Wallace, M. R.; Southwick, F. S.; Kingsmore, S. F. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.56-64&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039936#id-name=PMC&rft_id=info:pmid/11984006&rft_id=info:doi/10.1007/bf03402003&rft.aulast=Tchernev&rft.aufirst=V. T.&rft.au=Mansfield, T. A.&rft.au=Giot, L.&rft.au=Kumar, A. M.&rft.au=Nandabalan, K.&rft.au=Li, Y.&rft.au=Mishra, V. S.&rft.au=Detter, J. C.&rft.au=Rothberg, J. M.&rft.au=Wallace, M. R.&rft.au=Southwick, F. S.&rft.au=Kingsmore, S. F.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039936&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">

[6] Zou, C.; Li, J.; Bai, Y.; Gunning, W.; Wazer, D.; Band, V.; Gao, Q. (2005). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". Journal of Cell Biology. 171 (3): 437–445. doi:10.1083/jcb.200506185. PMC 2171251. PMID 16275750.437-445&rft.date=2005&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171251#id-name=PMC&rft_id=info:pmid/16275750&rft_id=info:doi/10.1083/jcb.200506185&rft.aulast=Zou&rft.aufirst=C.&rft.au=Li, J.&rft.au=Bai, Y.&rft.au=Gunning, W.&rft.au=Wazer, D.&rft.au=Band, V.&rft.au=Gao, Q.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171251&rfr_id=info:sid/en.wikipedia.org:CNTROB" class="Z3988">

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CNTROB

References

External links

Further reading