CLK3 (gene)

CLK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EU9, 2EXE, 2WU6, 2WU7, 3RAW
Identifiers
Aliases	CLK3, PHPHCLK3/152, CDC like kinase 3
External IDs	OMIM: 602990; MGI: 1098670; HomoloGene: 101534; GeneCards: CLK3; OMA:CLK3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,645,414 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,673,143 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; left testis; ; right testis; ; monocyte; ; anterior pituitary; ; left lobe of thyroid gland; ; mucosa of transverse colon; ; skin of leg; ; minor salivary glands; ; skin of abdomen;
	Top expressed in
	thymus; ; granulocyte; ; lip; ; muscle of thigh; ; aortic valve; ; ascending aorta; ; neural layer of retina; ; fetal liver hematopoietic progenitor cell; ; superior surface of tongue; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; identical protein binding; RNA binding;
Cellular component	cytoplasm; nuclear speck; membrane; nucleoplasm; acrosomal vesicle; intermediate filament cytoskeleton; cytoplasmic vesicle; nucleus;
Biological process	phosphorylation; protein phosphorylation; regulation of RNA splicing; protein autophosphorylation; peptidyl-tyrosine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	1198
	102414
	ENSG00000179335
	ENSMUSG00000032316
	P49761
	O35492
	NM_001130028; NM_001292; NM_003992
	NM_007713
	NP_001123500; NP_003983
	NP_031739
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene.^[5]^[6] The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179335 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032316 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Jan 1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J Mol Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.665-72&rft.date=1995-01&rft_id=info:doi/10.1006/jmbi.1994.1763&rft_id=info:pmid/7990150&rft.aulast=Hanes&rft.aufirst=J&rft.au=von der Kammer, H&rft.au=Klaudiny, J&rft.au=Scheit, KH&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
^ Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501. S2CID 40593571.523-4&rft.date=1998-12&rft_id=https://api.semanticscholar.org/CorpusID:40593571#id-name=S2CID&rft_id=info:pmid/9856501&rft_id=info:doi/10.1007/s004390050861&rft.aulast=Talmadge&rft.aufirst=CB&rft.au=Finkernagel, S&rft.au=Sumegi, J&rft.au=Sciorra, L&rft.au=Rabinow, L&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
^ "Entrez Gene: CLK3 CDC-like kinase 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa, K&rft.au=Maruyama, K&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
Duncan PI, Stojdl DF, Marius RM, et al. (1998). "The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing". Exp. Cell Res. 241 (2): 300–8. doi:10.1006/excr.1998.4083. PMID 9637771.300-8&rft.date=1998&rft_id=info:doi/10.1006/excr.1998.4083&rft_id=info:pmid/9637771&rft.aulast=Duncan&rft.aufirst=PI&rft.au=Stojdl, DF&rft.au=Marius, RM&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.1436-50&rft.date=2004&rft_id=info:doi/10.1016/j.cub.2004.07.051&rft_id=https://api.semanticscholar.org/CorpusID:2371325#id-name=S2CID&rft_id=info:pmid/15324660&rft_id=info:bibcode/2004CBio...14.1436J&rft.aulast=Jin&rft.aufirst=J&rft.au=Smith, FD&rft.au=Stark, C&rft_id=https://doi.org/10.1016%2Fj.cub.2004.07.051&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan, K&rft.au=Hao, T&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.635-48&rft.date=2006&rft_id=info:doi/10.1016/j.cell.2006.09.026&rft_id=info:pmid/17081983&rft.aulast=Olsen&rft.aufirst=JV&rft.au=Blagoev, B&rft.au=Gnad, F&rft_id=https://doi.org/10.1016%2Fj.cell.2006.09.026&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.537-47&rft.date=2007&rft_id=info:hdl/10033/19756&rft_id=info:pmid/17192257&rft_id=info:doi/10.1074/mcp.T600062-MCP200&rft.aulast=Wissing&rft.aufirst=J&rft.au=Jänsch, L&rft.au=Nimtz, M&rft_id=https://doi.org/10.1074%2Fmcp.T600062-MCP200&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">

External links

Clk dual-specificity kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CLK3 genome location and CLK3 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179335 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032316 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7990150-5] Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Jan 1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J Mol Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.665-72&rft.date=1995-01&rft_id=info:doi/10.1006/jmbi.1994.1763&rft_id=info:pmid/7990150&rft.aulast=Hanes&rft.aufirst=J&rft.au=von der Kammer, H&rft.au=Klaudiny, J&rft.au=Scheit, KH&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">

[pmid9856501-6] Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501. S2CID 40593571.523-4&rft.date=1998-12&rft_id=https://api.semanticscholar.org/CorpusID:40593571#id-name=S2CID&rft_id=info:pmid/9856501&rft_id=info:doi/10.1007/s004390050861&rft.aulast=Talmadge&rft.aufirst=CB&rft.au=Finkernagel, S&rft.au=Sumegi, J&rft.au=Sciorra, L&rft.au=Rabinow, L&rfr_id=info:sid/en.wikipedia.org:CLK3 (gene)" class="Z3988">

[entrez-7] "Entrez Gene: CLK3 CDC-like kinase 3".

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CLK3 (gene)

References

Further reading

External links