CLEC2B

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.

CLEC2B
Identifiers
Aliases	CLEC2B, AICL, CLECSF2, HP10085, IFNRG1, C-type lectin domain family 2 member B
External IDs	OMIM: 603242; HomoloGene: 68443; GeneCards: CLEC2B; OMA:CLEC2B - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 9,852,369 bp End 9,869,386 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip periodontal fiber glutes vena cava pericardium mononuclear cell human penis monocyte vulva n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding identical protein binding Cellular component plasma membrane integral component of plasma membrane integral component of membrane membrane Biological process regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9976 n/a Ensembl ENSG00000110852 n/a UniProt Q92478 n/a RefSeq (mRNA) NM_005127 n/a RefSeq (protein) NP_005118 n/a Location (UCSC) Chr 12: 9.85 – 9.87 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) protein superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length nucleotide sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

External links

• Human CLEC2B genome location and CLEC2B gene details page in the UCSC Genome Browser.

Further reading

• Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.585-90&rft.date=1999&rft_id=info:doi/10.1016/S0959-440X(99)50009-3&rft_id=info:pmid/10508765&rft.au=Drickamer K&rfr_id=info:sid/en.wikipedia.org:CLEC2B" class="Z3988">
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.au=Gerhard DS&rft.au=Wagner L&rft.au=Feingold EA&rft.au=Shenmen, CM&rft.au=Grouse, LH&rft.au=Schuler, G&rft.au=Klein, SL&rft.au=Old, S&rft.au=Rasooly, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:CLEC2B" class="Z3988">
• Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048. S2CID 30955198.44-55&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:30955198#id-name=S2CID&rft_id=info:pmid/12945048&rft_id=info:doi/10.1002/prot.10440&rft.aulast=Ebner&rft.aufirst=S&rft.au=Sharon, N&rft.au=Ben-Tal, N&rfr_id=info:sid/en.wikipedia.org:CLEC2B" class="Z3988">
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.au=Strausberg RL&rft.au=Feingold EA&rft.au=Grouse LH&rft.au=Derge, JG&rft.au=Klausner, RD&rft.au=Collins, FS&rft.au=Wagner, L&rft.au=Shenmen, CM&rft.au=Schuler, GD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:CLEC2B" class="Z3988">
• Renedo M, Arce I, Montgomery K, et al. (2000). "A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2". Genomics. 65 (2): 129–36. doi:10.1006/geno.2000.6163. PMID 10783260.129-36&rft.date=2000&rft_id=info:doi/10.1006/geno.2000.6163&rft_id=info:pmid/10783260&rft.au=Renedo M&rft.au=Arce I&rft.au=Montgomery K&rft.au=Roda-Navarro, Pedro&rft.au=Lee, Eunice&rft.au=Kucherlapati, Raju&rft.au=Fernández-Ruiz, Elena&rfr_id=info:sid/en.wikipedia.org:CLEC2B" class="Z3988">
• Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.1–2&rft.pages=161-7&rft.date=1999&rft_id=info:doi/10.1016/S0378-1119(99)50004-9&rft_id=info:pmid/10072769&rft.aulast=Yokoyama-Kobayashi&rft.aufirst=M&rft.au=Yamaguchi, T&rft.au=Sekine, S&rft.au=Kato, S&rfr_id=info:sid/en.wikipedia.org:CLEC2B" class="Z3988">
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.791-806&rft.date=1997&rft_id=info:doi/10.1101/gr.6.9.791&rft_id=info:pmid/8889548&rft.aulast=Bonaldo&rft.aufirst=MF&rft.au=Lennon, G&rft.au=Soares, MB&rft_id=https://doi.org/10.1101%2Fgr.6.9.791&rfr_id=info:sid/en.wikipedia.org:CLEC2B" class="Z3988">