Cell death-inducing DFFA-like effector b , also known as CIDEB gene .[ 5] [ 6] [ 7]
In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease.[ 8] knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis . The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis . In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.[ 9] in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets.[ 10] [ 8]
^ a b c ENSG00000285199 GRCh38: Ensembl release 89: ENSG00000136305, ENSG00000285199 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022219 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: CIDEB cell death-inducing DFFA-like effector b" .^ Ye J, Zhong Li J, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P (2009). "Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B." Cell Metabolism . 9 (2): 177–190. doi :10.1016/j.cmet.2008.12.013 PMID 19187774 . ^ Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, Pan X, Li P (May 2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta . 1801 (5): 577–86. doi :10.1016/j.bbalip.2010.01.012 . PMID 20123130 . ^ a b Verweij N, Haas ME, Nielsen JB, Sosina OA, Kim M, Akbari P, De T, Hindy G, Bovijn J, Persaud T, Miloscio L, Germino M, Panagis L, Watanabe K, Mbatchou J (2022-07-28). "Germline Mutations in CIDEB and Protection against Liver Disease" . New England Journal of Medicine . 387 (4): 332–344. doi :10.1056/NEJMoa2117872 ISSN 0028-4793 . PMID 35939579 . S2CID 251143047 . ^ Zhong Li J, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P (2007). "Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogeneis and fatty acid oxidation" . Diabetes . 56 (10): 2523–2532. doi :10.2337/db07-0040 PMID 17646209 . ^ Xu W, Wu L, Yu M, Chen FJ, Arshad M, Xia X, Ren H, Yu J, Xu L, Xu D, Li JZ, Li P, Zhou L (2016-02-26). "Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes" . The Journal of Biological Chemistry . 291 (9): 4282–4293. doi :10.1074/jbc.M115.701094 ISSN 1083-351X . PMC 4813457 PMID 26733203 .
Inohara N, Koseki T, Chen S, et al. (1998). "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor" . EMBO J . 17 (9): 2526–33. doi :10.1093/emboj/17.9.2526 . PMC 1170863 PMID 9564035 . Lugovskoy AA, Zhou P, Chou JJ, et al. (2000). "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis" . Cell . 99 (7): 747–55. doi :10.1016/S0092-8674(00)81672-4 PMID 10619428 . Chen Z, Guo K, Toh SY, et al. (2000). "Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis" . J. Biol. Chem . 275 (30): 22619–22. doi :10.1074/jbc.C000207200 PMID 10837461 . Liang L, Zhao M, Xu Z, et al. (2003). "Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family" . Biochem. J . 370 (Pt 1): 195–203. doi :10.1042/BJ20020656 . PMC 1223158 PMID 12429024 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Erdtmann L, Franck N, Lerat H, et al. (2003). "The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis" (PDF) . J. Biol. Chem . 278 (20): 18256–64. doi :10.1074/jbc.M209732200 PMID 12595532 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Da L, Li D, Yokoyama KK, et al. (2006). "Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene" . Biochem. J . 393 (Pt 3): 779–88. doi :10.1042/BJ20051027 . PMC 1360731 PMID 16248853 . Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, Pan X, Li P, et al. (2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta . 1801 (Pt 5): 577–586. doi :10.1016/j.bbalip.2010.01.012 . PMID 20123130 .
