CGS-9896

CGS-9896
Clinical data
ATC code	none;
Identifiers
	IUPAC name 2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one;
CAS Number	77779-36-3 ;
PubChem CID	108030;
ChemSpider	97139 ;
UNII	86PWQ4PVN0;
ChEMBL	ChEMBL507327;
CompTox Dashboard (EPA)	DTXSID20998970 ;
Chemical and physical data
Formula	C16H10ClN3O
Molar mass	295.73 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl;
	InChI InChI=1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H ; Key:QCBUAKLOWCOUCR-UHFFFAOYSA-N ;
	(what is this?) (verify)

CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.^[1]

CGS-9896 is a benzodiazepine receptor partial agonist which produces long-lasting anxiolytic and anticonvulsant effects in animal studies but does not produce sedative effects.^[2]^[3] It also increases appetite,^[4] and reduces the development of gastrointestinal ulcers following chronic stress.^[5]

References

^ Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex". Pharmacol Biochem Behav. 31 (2): 249–54. doi:10.1016/0091-3057(88)90342-5. PMID 2854261. S2CID 21773709.249-54&rft.date=1988-10&rft_id=https://api.semanticscholar.org/CorpusID:21773709#id-name=S2CID&rft_id=info:pmid/2854261&rft_id=info:doi/10.1016/0091-3057(88)90342-5&rft.aulast=Leidenheimer&rft.aufirst=NJ&rft.au=Schechter, MD&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">
^ Bernasconi R, Marescaux C, Vergnes M, et al. (1988). "Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models". J Neural Transm. 71 (1): 11–27. doi:10.1007/BF01286306. PMID 3343593. S2CID 31525533.11-27&rft.date=1988&rft_id=https://api.semanticscholar.org/CorpusID:31525533#id-name=S2CID&rft_id=info:pmid/3343593&rft_id=info:doi/10.1007/BF01286306&rft.aulast=Bernasconi&rft.aufirst=R&rft.au=Marescaux, C&rft.au=Vergnes, M&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">
^ Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch. Toxicol. 64 (5): 412–3. Bibcode:1990ArTox..64..412R. doi:10.1007/BF01973465. PMID 2206111. S2CID 19084019.412-3&rft.date=1990&rft_id=info:doi/10.1007/BF01973465&rft_id=https://api.semanticscholar.org/CorpusID:19084019#id-name=S2CID&rft_id=info:pmid/2206111&rft_id=info:bibcode/1990ArTox..64..412R&rft.aulast=Rump&rft.aufirst=S&rft.au=Raszewski, W&rft.au=Gidynska, T&rft.au=Galecka, E&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">
^ Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2–3): 499–503. doi:10.1016/0091-3057(95)00020-W. PMID 7667375. S2CID 32809713.2–3&rft.pages=499-503&rft.date=1995&rft_id=https://api.semanticscholar.org/CorpusID:32809713#id-name=S2CID&rft_id=info:pmid/7667375&rft_id=info:doi/10.1016/0091-3057(95)50020-W&rft.aulast=Chen&rft.aufirst=SW&rft.au=Davies, MF&rft.au=Loew, GH&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">
^ Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer in rat". Clin Exp Pharmacol Physiol. 17 (2): 157–161. doi:10.1111/j.1440-1681.1990.tb01298.x. PMID 2109664. S2CID 37492286.157-161&rft.date=1990-02&rft_id=https://api.semanticscholar.org/CorpusID:37492286#id-name=S2CID&rft_id=info:pmid/2109664&rft_id=info:doi/10.1111/j.1440-1681.1990.tb01298.x&rft.aulast=Najim&rft.aufirst=RA&rft.au=Karim, KH&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">

This article about an anxiolytic is a stub. You can help Wikipedia by expanding it.

[1] Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex". Pharmacol Biochem Behav. 31 (2): 249–54. doi:10.1016/0091-3057(88)90342-5. PMID 2854261. S2CID 21773709.249-54&rft.date=1988-10&rft_id=https://api.semanticscholar.org/CorpusID:21773709#id-name=S2CID&rft_id=info:pmid/2854261&rft_id=info:doi/10.1016/0091-3057(88)90342-5&rft.aulast=Leidenheimer&rft.aufirst=NJ&rft.au=Schechter, MD&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">

[2] Bernasconi R, Marescaux C, Vergnes M, et al. (1988). "Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models". J Neural Transm. 71 (1): 11–27. doi:10.1007/BF01286306. PMID 3343593. S2CID 31525533.11-27&rft.date=1988&rft_id=https://api.semanticscholar.org/CorpusID:31525533#id-name=S2CID&rft_id=info:pmid/3343593&rft_id=info:doi/10.1007/BF01286306&rft.aulast=Bernasconi&rft.aufirst=R&rft.au=Marescaux, C&rft.au=Vergnes, M&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">

[3] Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch. Toxicol. 64 (5): 412–3. Bibcode:1990ArTox..64..412R. doi:10.1007/BF01973465. PMID 2206111. S2CID 19084019.412-3&rft.date=1990&rft_id=info:doi/10.1007/BF01973465&rft_id=https://api.semanticscholar.org/CorpusID:19084019#id-name=S2CID&rft_id=info:pmid/2206111&rft_id=info:bibcode/1990ArTox..64..412R&rft.aulast=Rump&rft.aufirst=S&rft.au=Raszewski, W&rft.au=Gidynska, T&rft.au=Galecka, E&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">

[4] Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2–3): 499–503. doi:10.1016/0091-3057(95)00020-W. PMID 7667375. S2CID 32809713.2–3&rft.pages=499-503&rft.date=1995&rft_id=https://api.semanticscholar.org/CorpusID:32809713#id-name=S2CID&rft_id=info:pmid/7667375&rft_id=info:doi/10.1016/0091-3057(95)50020-W&rft.aulast=Chen&rft.aufirst=SW&rft.au=Davies, MF&rft.au=Loew, GH&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">

[5] Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer in rat". Clin Exp Pharmacol Physiol. 17 (2): 157–161. doi:10.1111/j.1440-1681.1990.tb01298.x. PMID 2109664. S2CID 37492286.157-161&rft.date=1990-02&rft_id=https://api.semanticscholar.org/CorpusID:37492286#id-name=S2CID&rft_id=info:pmid/2109664&rft_id=info:doi/10.1111/j.1440-1681.1990.tb01298.x&rft.aulast=Najim&rft.aufirst=RA&rft.au=Karim, KH&rfr_id=info:sid/en.wikipedia.org:CGS-9896" class="Z3988">

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Clinical data

ATC code	none
Identifiers
IUPAC name 2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one
CAS Number	77779-36-3^Y
PubChem CID	108030
ChemSpider	97139^N
UNII	86PWQ4PVN0
ChEMBL	ChEMBL507327
CompTox Dashboard (EPA)	DTXSID20998970
Chemical and physical data
Formula	C₁₆H₁₀ClN₃O
Molar mass	295.73 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl
InChI InChI=1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H^N Key:QCBUAKLOWCOUCR-UHFFFAOYSA-N^N
^NY (what is this?) (verify)