CD 205

LY75
Identifiers
Aliases	LY75, CD205, CLEC13B, DEC-205, GP200-MR6, LY-75, lymphocyte antigen 75
External IDs	OMIM: 604524; MGI: 106662; HomoloGene: 31085; GeneCards: LY75; OMA:LY75 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	159,904,756 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	60,213,647 bp
RNA expression pattern
	Top expressed in
	thymus; ; epithelium of nasopharynx; ; jejunal mucosa; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; nasal epithelium; ; skin of thigh; ; mucosa of sigmoid colon; ; lactiferous duct; ; pancreatic ductal cell;
	Top expressed in
	granulocyte; ; thymus; ; primitive streak; ; yolk sac; ; lumbar spinal ganglion; ; jejunum; ; duodenum; ; tail of embryo; ; epiblast; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; carbohydrate binding; transmembrane signaling receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	inflammatory response; endocytosis; immune response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4065
	17076
	ENSG00000054219
	ENSMUSG00000026980
	O60449
	Q60767
	NM_002349
	NM_013825
	NP_001185688; NP_001185689
	NP_038853
	Wikidata
View/Edit Human	View/Edit Mouse

CD205 also called Lymphocyte antigen 75 is a protein that in humans is encoded by the LY75 gene.^[5]^[6]

CD205 is also known as DEC-205.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026980 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kato M, Neil TK, Clark GJ, Morris CM, Sorg RV, Hart DN (Jun 1998). "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells". Immunogenetics. 47 (6): 442–50. doi:10.1007/s002510050381. PMID 9553150. S2CID 10949216.442-50&rft.date=1998-06&rft_id=https://api.semanticscholar.org/CorpusID:10949216#id-name=S2CID&rft_id=info:pmid/9553150&rft_id=info:doi/10.1007/s002510050381&rft.aulast=Kato&rft.aufirst=M&rft.au=Neil, TK&rft.au=Clark, GJ&rft.au=Morris, CM&rft.au=Sorg, RV&rft.au=Hart, DN&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">
^ "Entrez Gene: LY75 lymphocyte antigen 75".

Tungekar MF, Gatter KC, Ritter MA (1996). "Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124)". Br. J. Cancer. 73 (4): 429–32. doi:10.1038/bjc.1996.77. PMC 2074450. PMID 8595155.429-32&rft.date=1996&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074450#id-name=PMC&rft_id=info:pmid/8595155&rft_id=info:doi/10.1038/bjc.1996.77&rft.aulast=Tungekar&rft.aufirst=MF&rft.au=Gatter, KC&rft.au=Ritter, MA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074450&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">
al-Tubuly AA, Luqmani YA, Shousha S, et al. (1996). "Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast". Br. J. Cancer. 74 (7): 1005–11. doi:10.1038/bjc.1996.481. PMC 2077117. PMID 8855966.1005-11&rft.date=1996&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077117#id-name=PMC&rft_id=info:pmid/8855966&rft_id=info:doi/10.1038/bjc.1996.481&rft.au=al-Tubuly AA&rft.au=Luqmani YA&rft.au=Shousha S&rft.au=Melcher, D&rft.au=Ritter, MA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077117&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">
McKay PF, Imami N, Johns M, et al. (1999). "The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family". Eur. J. Immunol. 28 (12): 4071–83. doi:10.1002/(SICI)1521-4141(199812)28:12<4071::AID-IMMU4071>3.0.CO;2-O. PMID 9862343. S2CID 13656389.4071-83&rft.date=1999&rft_id=https://api.semanticscholar.org/CorpusID:13656389#id-name=S2CID&rft_id=info:pmid/9862343&rft_id=info:doi/10.1002/(SICI)1521-4141(199812)28:12<4071::AID-IMMU4071>3.0.CO;2-O&rft.au=McKay PF&rft.au=Imami N&rft.au=Johns M&rft.au=Taylor-Fishwick, David A.&rft.au=Sedibane, Lucas M.&rft.au=Totty, Nicholas F.&rft.au=Hsuan, J. Justin&rft.au=Palmer, Donald B.&rft.au=George, Andrew J. T.&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">
Palmer DB, Crompton T, Marandi MB, et al. (1999). "Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus development". Immunology. 96 (2): 236–45. doi:10.1046/j.1365-2567.1999.00691.x. PMC 2326733. PMID 10233701.236-45&rft.date=1999&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2326733#id-name=PMC&rft_id=info:pmid/10233701&rft_id=info:doi/10.1046/j.1365-2567.1999.00691.x&rft.au=Palmer DB&rft.au=Crompton T&rft.au=Marandi MB&rft.au=George, AJ&rft.au=Ritter, MA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2326733&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">
Guo M, Gong S, Maric S, et al. (2000). "A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells". Hum. Immunol. 61 (8): 729–38. doi:10.1016/S0198-8859(00)00144-0. PMID 10980384.729-38&rft.date=2000&rft_id=info:doi/10.1016/S0198-8859(00)00144-0&rft_id=info:pmid/10980384&rft.au=Guo M&rft.au=Gong S&rft.au=Maric S&rft.au=Misulovin, Ziva&rft.au=Pack, Maggi&rft.au=Mahnke, Karsten&rft.au=Nussenzweig, Michel C&rft.au=Steinman, Ralph M&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">
Kato M, Neil TK, Fearnley DB, et al. (2000). "Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells". Int. Immunol. 12 (11): 1511–9. doi:10.1093/intimm/12.11.1511. PMID 11058570.1511-9&rft.date=2000&rft_id=info:doi/10.1093/intimm/12.11.1511&rft_id=info:pmid/11058570&rft.au=Kato M&rft.au=Neil TK&rft.au=Fearnley DB&rft.au=McLellan, AD&rft.au=Vuckovic, S&rft.au=Hart, DN&rft_id=https://doi.org/10.1093%2Fintimm%2F12.11.1511&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">
Kato M, Khan S, Gonzalez N, et al. (2003). "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1". J. Biol. Chem. 278 (36): 34035–41. doi:10.1074/jbc.M303112200. PMID 12824192.34035-41&rft.date=2003&rft_id=info:doi/10.1074/jbc.M303112200&rft_id=info:pmid/12824192&rft.au=Kato M&rft.au=Khan S&rft.au=Gonzalez N&rft.au=O'Neill, BP&rft.au=McDonald, KJ&rft.au=Cooper, BJ&rft.au=Angel, NZ&rft.au=Hart, DN&rft_id=https://doi.org/10.1074%2Fjbc.M303112200&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">
Bozzacco L, Trumpfheller C, Siegal FP, et al. (2007). "DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 T cells in a spectrum of human MHC I haplotypes". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1289–94. Bibcode:2007PNAS..104.1289B. doi:10.1073/pnas.0610383104. PMC 1783096. PMID 17229838.1289-94&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783096#id-name=PMC&rft_id=info:pmid/17229838&rft_id=info:doi/10.1073/pnas.0610383104&rft_id=info:bibcode/2007PNAS..104.1289B&rft.au=Bozzacco L&rft.au=Trumpfheller C&rft.au=Siegal FP&rft.au=Mehandru, S.&rft.au=Markowitz, M.&rft.au=Carrington, M.&rft.au=Nussenzweig, M. C.&rft.au=Piperno, A. G.&rft.au=Steinman, R. M.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783096&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">
Nonaka D, Henley JD, Chiriboga L, Yee H (2007). "Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms". Am. J. Surg. Pathol. 31 (7): 1038–44. doi:10.1097/PAS.0b013e31802b4917. PMID 17592270. S2CID 30502411.1038-44&rft.date=2007&rft_id=https://api.semanticscholar.org/CorpusID:30502411#id-name=S2CID&rft_id=info:pmid/17592270&rft_id=info:doi/10.1097/PAS.0b013e31802b4917&rft.aulast=Nonaka&rft.aufirst=D&rft.au=Henley, JD&rft.au=Chiriboga, L&rft.au=Yee, H&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000054219 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026980 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9553150-5] Kato M, Neil TK, Clark GJ, Morris CM, Sorg RV, Hart DN (Jun 1998). "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells". Immunogenetics. 47 (6): 442–50. doi:10.1007/s002510050381. PMID 9553150. S2CID 10949216.442-50&rft.date=1998-06&rft_id=https://api.semanticscholar.org/CorpusID:10949216#id-name=S2CID&rft_id=info:pmid/9553150&rft_id=info:doi/10.1007/s002510050381&rft.aulast=Kato&rft.aufirst=M&rft.au=Neil, TK&rft.au=Clark, GJ&rft.au=Morris, CM&rft.au=Sorg, RV&rft.au=Hart, DN&rfr_id=info:sid/en.wikipedia.org:CD 205" class="Z3988">

[entrez-6] "Entrez Gene: LY75 lymphocyte antigen 75".

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CD 205

References

Further reading