The enzyme CDP-glucose 4,6-dehydratase (EC 4.2.1.45) catalyzes the chemical reaction
| CDP-glucose 4,6-dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.45 | ||||||||
| CAS no. | 37259-55-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- CDP-glucose CDP-4-dehydro-6-deoxy-D-glucose H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in starch and sucrose metabolism. It employs one cofactor, NAD .
Nomenclature
editThe systematic name of this enzyme class is CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include:
- cytidine diphosphoglucose oxidoreductase, and
- CDP-glucose 4,6-hydro-lyase.
Structural studies
editAs of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1RKX and 1WVG.
References
edit- Hey AE, Elbein AD (1966). "Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241 (22): 5473–8. doi:10.1016/S0021-9258(18)96454-9. PMID 4380946.5473-8&rft.date=1966&rft_id=info:doi/10.1016/S0021-9258(18)96454-9&rft_id=info:pmid/4380946&rft.aulast=Hey&rft.aufirst=AE&rft.au=Elbein, AD&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2996454-9&rfr_id=info:sid/en.wikipedia.org:CDP-glucose 4,6-dehydratase" class="Z3988">
- Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL (1966). "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3 Cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241 (18): 4283–7. doi:10.1016/S0021-9258(18)99780-2. PMID 4288651.4283-7&rft.date=1966&rft_id=info:doi/10.1016/S0021-9258(18)99780-2&rft_id=info:pmid/4288651&rft.aulast=Matsuhashi&rft.aufirst=S&rft.au=Matsuhashi, M&rft.au=Brown, JG&rft.au=Strominger, JL&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2999780-2&rfr_id=info:sid/en.wikipedia.org:CDP-glucose 4,6-dehydratase" class="Z3988">
- Melo A, Elliott WH, Glaser L (1968). "The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 243 (7): 1467–74. doi:10.1016/S0021-9258(18)93566-0. PMID 4869560.1467-74&rft.date=1968&rft_id=info:doi/10.1016/S0021-9258(18)93566-0&rft_id=info:pmid/4869560&rft.aulast=Melo&rft.aufirst=A&rft.au=Elliott, WH&rft.au=Glaser, L&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2993566-0&rfr_id=info:sid/en.wikipedia.org:CDP-glucose 4,6-dehydratase" class="Z3988">
