Wikipedia

CDCA8

Borealin is a protein that in humans is encoded by the CDCA8 gene.[5][6][7]

CDCA8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDCA8, BOR, BOREALIN, DasraB, MESRGP, cell division cycle associated 8
External IDsOMIM: 609977; MGI: 1196274; HomoloGene: 23075; GeneCards: CDCA8; OMA:CDCA8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

55143

52276

Ensembl

ENSG00000134690

ENSMUSG00000028873

UniProt

Q53HL2

Q8BHX3

RefSeq (mRNA)

NM_018101
NM_001256875

NM_026560

RefSeq (protein)

NP_001243804
NP_060571

NP_080836

Location (UCSC)Chr 1: 37.69 – 37.71 MbChr 4: 124.81 – 124.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[7][8]

Interactions

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CDCA8 has been shown to interact with INCENP,[8] Survivin[6][8] and Aurora B kinase.[6][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134690 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028873 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.73-83&rft.date=2001-05&rft_id=info:doi/10.2174/1568009013334241&rft_id=info:pmid/12188893&rft.aulast=Walker&rft.aufirst=MG&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  6. ^ a b c Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.187-202&rft.date=2004-07&rft_id=info:doi/10.1016/j.cell.2004.06.026&rft_id=info:pmid/15260989&rft.aulast=Sampath&rft.aufirst=SC&rft.au=Ohi, R&rft.au=Leismann, O&rft.au=Salic, A&rft.au=Pozniakovski, A&rft.au=Funabiki, H&rft_id=https://doi.org/10.1016%2Fj.cell.2004.06.026&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  7. ^ a b "Entrez Gene: CDCA8 cell division cycle associated 8".
  8. ^ a b c d Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.179-91&rft.date=2004-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172304#id-name=PMC&rft_id=info:pmid/15249581&rft_id=info:doi/10.1083/jcb.200404001&rft.aulast=Gassmann&rft.aufirst=R&rft.au=Carvalho, A&rft.au=Henzing, AJ&rft.au=Ruchaud, S&rft.au=Hudson, DF&rft.au=Honda, R&rft.au=Nigg, EA&rft.au=Gerloff, DL&rft.au=Earnshaw, WC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172304&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">

Further reading

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  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994-01&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997-10&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa, K&rft.au=Maruyama, K&rft.au=Suyama, A&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH (Jan 2005). "Proteome analysis of the human mitotic spindle". Molecular & Cellular Proteomics. 4 (1): 35–43. doi:10.1074/mcp.M400158-MCP200. PMID 15561729.35-43&rft.date=2005-01&rft_id=info:doi/10.1074/mcp.M400158-MCP200&rft_id=info:pmid/15561729&rft.aulast=Sauer&rft.aufirst=G&rft.au=Körner, R&rft.au=Hanisch, A&rft.au=Ries, A&rft.au=Nigg, EA&rft.au=Silljé, HH&rft_id=https://doi.org/10.1074%2Fmcp.M400158-MCP200&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.77-83&rft.date=2005-01&rft_id=info:doi/10.1038/nature03207&rft_id=https://api.semanticscholar.org/CorpusID:4344740#id-name=S2CID&rft_id=info:pmid/15635413&rft_id=info:bibcode/2005Natur.433...77A&rft.aulast=Andersen&rft.aufirst=JS&rft.au=Lam, YW&rft.au=Leung, AK&rft.au=Ong, SE&rft.au=Lyon, CE&rft.au=Lamond, AI&rft.au=Mann, M&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Vader G, Kauw JJ, Medema RH, Lens SM (Jan 2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody". EMBO Reports. 7 (1): 85–92. doi:10.1038/sj.embor.7400562. PMC 1369225. PMID 16239925.85-92&rft.date=2006-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1369225#id-name=PMC&rft_id=info:pmid/16239925&rft_id=info:doi/10.1038/sj.embor.7400562&rft.aulast=Vader&rft.aufirst=G&rft.au=Kauw, JJ&rft.au=Medema, RH&rft.au=Lens, SM&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1369225&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P, Wheatley SP (Jan 2006). "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis". The Journal of Biological Chemistry. 281 (2): 1286–95. doi:10.1074/jbc.M508773200. PMID 16291752.1286-95&rft.date=2006-01&rft_id=info:doi/10.1074/jbc.M508773200&rft_id=info:pmid/16291752&rft.aulast=Noton&rft.aufirst=EA&rft.au=Colnaghi, R&rft.au=Tate, S&rft.au=Starck, C&rft.au=Carvalho, A&rft.au=Ko Ferrigno, P&rft.au=Wheatley, SP&rft_id=https://doi.org/10.1074%2Fjbc.M508773200&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM (Apr 2006). "Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer". Experimental Cell Research. 312 (7): 962–73. doi:10.1016/j.yexcr.2005.12.015. PMID 16427043.962-73&rft.date=2006-04&rft_id=info:doi/10.1016/j.yexcr.2005.12.015&rft_id=info:pmid/16427043&rft.aulast=Chang&rft.aufirst=JL&rft.au=Chen, TH&rft.au=Wang, CF&rft.au=Chiang, YH&rft.au=Huang, YL&rft.au=Wong, FH&rft.au=Chou, CK&rft.au=Chen, CM&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH (Apr 2006). "Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres". Molecular Biology of the Cell. 17 (4): 1897–909. doi:10.1091/mbc.E05-08-0727. PMC 1415303. PMID 16436504.1897-909&rft.date=2006-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1415303#id-name=PMC&rft_id=info:pmid/16436504&rft_id=info:doi/10.1091/mbc.E05-08-0727&rft.aulast=Lens&rft.aufirst=SM&rft.au=Rodriguez, JA&rft.au=Vader, G&rft.au=Span, SW&rft.au=Giaccone, G&rft.au=Medema, RH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1415303&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G (Aug 2006). "Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown". Oncogene. 25 (35): 4867–79. doi:10.1038/sj.onc.1209499. PMID 16547492. S2CID 27074707.4867-79&rft.date=2006-08&rft_id=https://api.semanticscholar.org/CorpusID:27074707#id-name=S2CID&rft_id=info:pmid/16547492&rft_id=info:doi/10.1038/sj.onc.1209499&rft.aulast=Rodriguez&rft.aufirst=JA&rft.au=Lens, SM&rft.au=Span, SW&rft.au=Vader, G&rft.au=Medema, RH&rft.au=Kruyt, FA&rft.au=Giaccone, G&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.5391-6&rft.date=2006-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365#id-name=PMC&rft_id=info:pmid/16565220&rft_id=info:doi/10.1073/pnas.0507066103&rft_id=info:bibcode/2006PNAS..103.5391N&rft.aulast=Nousiainen&rft.aufirst=M&rft.au=Silljé, HH&rft.au=Sauer, G&rft.au=Nigg, EA&rft.au=Körner, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Klein UR, Nigg EA, Gruneberg U (Jun 2006). "Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP". Molecular Biology of the Cell. 17 (6): 2547–58. doi:10.1091/mbc.E05-12-1133. PMC 1474794. PMID 16571674.2547-58&rft.date=2006-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474794#id-name=PMC&rft_id=info:pmid/16571674&rft_id=info:doi/10.1091/mbc.E05-12-1133&rft.aulast=Klein&rft.aufirst=UR&rft.au=Nigg, EA&rft.au=Gruneberg, U&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474794&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
  • Kaur H, Stiff AC, Date DA, Taylor WR (2007). "Analysis of mitotic phosphorylation of borealin". BMC Cell Biology. 8: 5. doi:10.1186/1471-2121-8-5. PMC 1794407. PMID 17241471.
  • Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y (May 2007). "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis" (PDF). Cancer Research. 67 (9): 4113–22. doi:10.1158/0008-5472.CAN-06-4705. PMID 17483322.4113-22&rft.date=2007-05&rft_id=info:doi/10.1158/0008-5472.CAN-06-4705&rft_id=info:pmid/17483322&rft.aulast=Hayama&rft.aufirst=S&rft.au=Daigo, Y&rft.au=Yamabuki, T&rft.au=Hirata, D&rft.au=Kato, T&rft.au=Miyamoto, M&rft.au=Ito, T&rft.au=Tsuchiya, E&rft.au=Kondo, S&rft.au=Nakamura, Y&rft_id=https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1A_from_Phosphorylation_and_Activation_of_Cell_Division_Cycle_Associated_8_by_Aurora_Kinase_B_Plays_a_Significant_Role_in_Human_Lung_Carcinogenesis/22370493/1/files/39815568.pdf&rfr_id=info:sid/en.wikipedia.org:CDCA8" class="Z3988">
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