Wikipedia

CDC6

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.[5][6]

CDC6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC6, CDC18L, HsCDC18, Hscell division cycle 6, MGORS5
External IDsOMIM: 602627; MGI: 1345150; HomoloGene: 68172; GeneCards: CDC6; OMA:CDC6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

990

23834

Ensembl

ENSG00000094804

ENSMUSG00000017499

UniProt

Q99741

O89033

RefSeq (mRNA)

NM_001254

NM_001025779
NM_011799
NM_001362735

RefSeq (protein)

NP_001245

NP_001020950
NP_035929
NP_001349664

Location (UCSC)Chr 17: 40.29 – 40.3 MbChr 11: 98.8 – 98.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.[7]

Interactions

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CDC6 has been shown to interact with ORC1L,[6][8] ORC2L,[8][9] Cyclin A2,[6][10] PPP2R3B,[11] MCM3,[9][12] PPP2R3A,[13] MCM7[8][12] and PSKH1.[10]

See also

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  • Cdc6, the family of orthologs in eukaryotes

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000094804 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017499 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Williams RS, Shohet RV, Stillman B (February 1997). "A human protein related to yeast Cdc6p". Proc Natl Acad Sci U S A. 94 (1): 142–7. Bibcode:1997PNAS...94..142S. doi:10.1073/pnas.94.1.142. PMC 19260. PMID 8990175.142-7&rft.date=1997-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC19260#id-name=PMC&rft_id=info:pmid/8990175&rft_id=info:doi/10.1073/pnas.94.1.142&rft_id=info:bibcode/1997PNAS...94..142S&rft.aulast=Williams&rft.aufirst=RS&rft.au=Shohet, RV&rft.au=Stillman, B&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC19260&rfr_id=info:sid/en.wikipedia.org:CDC6" class="Z3988">
  6. ^ a b c Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A (May 1998). "Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase". Mol Cell Biol. 18 (5): 2758–67. doi:10.1128/mcb.18.5.2758. PMC 110655. PMID 9566895.2758-67&rft.date=1998-05&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110655#id-name=PMC&rft_id=info:pmid/9566895&rft_id=info:doi/10.1128/mcb.18.5.2758&rft.aulast=Saha&rft.aufirst=P&rft.au=Chen, J&rft.au=Thome, KC&rft.au=Lawlis, SJ&rft.au=Hou, ZH&rft.au=Hendricks, M&rft.au=Parvin, JD&rft.au=Dutta, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110655&rfr_id=info:sid/en.wikipedia.org:CDC6" class="Z3988">
  7. ^ "Entrez Gene: CDC6 cell division cycle 6 homolog (S. cerevisiae)".
  8. ^ a b c Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1). England: 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.111-28&rft.date=2003-03&rft.issn=0022-2836&rft_id=info:pmid/12614612&rft_id=info:doi/10.1016/S0022-2836(03)50079-2&rft.aulast=Kneissl&rft.aufirst=Margot&rft.au=Pütter Vera&rft.au=Szalay Aladar A&rft.au=Grummt Friedrich&rfr_id=info:sid/en.wikipedia.org:CDC6" class="Z3988">
  9. ^ a b Méndez, J; Stillman B (November 2000). "Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis". Mol. Cell. Biol. 20 (22). UNITED STATES: 8602–12. doi:10.1128/MCB.20.22.8602-8612.2000. ISSN 0270-7306. PMC 102165. PMID 11046155.8602-12&rft.date=2000-11&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC102165#id-name=PMC&rft.issn=0270-7306&rft_id=info:pmid/11046155&rft_id=info:doi/10.1128/MCB.20.22.8602-8612.2000&rft.aulast=Méndez&rft.aufirst=J&rft.au=Stillman B&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC102165&rfr_id=info:sid/en.wikipedia.org:CDC6" class="Z3988">
  10. ^ a b Petersen, B O; Lukas J; Sørensen C S; Bartek J; Helin K (January 1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2). ENGLAND: 396–410. doi:10.1093/emboj/18.2.396. ISSN 0261-4189. PMC 1171134. PMID 9889196.396-410&rft.date=1999-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171134#id-name=PMC&rft.issn=0261-4189&rft_id=info:pmid/9889196&rft_id=info:doi/10.1093/emboj/18.2.396&rft.aulast=Petersen&rft.aufirst=B O&rft.au=Lukas J&rft.au=Sørensen C S&rft.au=Bartek J&rft.au=Helin K&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171134&rfr_id=info:sid/en.wikipedia.org:CDC6" class="Z3988">
  11. ^ Yan, Z; Fedorov S A; Mumby M C; Williams R S (February 2000). "PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells". Mol. Cell. Biol. 20 (3). UNITED STATES: 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. ISSN 0270-7306. PMC 85219. PMID 10629059.1021-9&rft.date=2000-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85219#id-name=PMC&rft.issn=0270-7306&rft_id=info:pmid/10629059&rft_id=info:doi/10.1128/MCB.20.3.1021-1029.2000&rft.aulast=Yan&rft.aufirst=Z&rft.au=Fedorov S A&rft.au=Mumby M C&rft.au=Williams R S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85219&rfr_id=info:sid/en.wikipedia.org:CDC6" class="Z3988">
  12. ^ a b Fujita, M; Yamada C; Goto H; Yokoyama N; Kuzushima K; Inagaki M; Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. 274 (36). UNITED STATES: 25927–32. doi:10.1074/jbc.274.36.25927. ISSN 0021-9258. PMID 10464337.25927-32&rft.date=1999-09&rft.issn=0021-9258&rft_id=info:pmid/10464337&rft_id=info:doi/10.1074/jbc.274.36.25927&rft.aulast=Fujita&rft.aufirst=M&rft.au=Yamada C&rft.au=Goto H&rft.au=Yokoyama N&rft.au=Kuzushima K&rft.au=Inagaki M&rft.au=Tsurumi T&rft_id=https://doi.org/10.1074%2Fjbc.274.36.25927&rfr_id=info:sid/en.wikipedia.org:CDC6" class="Z3988">
  13. ^ Davis, Anthony J; Yan Zhen; Martinez Bobbie; Mumby Marc C (June 2008). "Protein Phosphatase 2A Is Targeted to Cell Division Control Protein 6 by a Calcium-binding Regulatory Subunit". J. Biol. Chem. 283 (23). United States: 16104–14. doi:10.1074/jbc.M710313200. ISSN 0021-9258. PMC 2414307. PMID 18397887.16104-14&rft.date=2008-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2414307#id-name=PMC&rft.issn=0021-9258&rft_id=info:pmid/18397887&rft_id=info:doi/10.1074/jbc.M710313200&rft.aulast=Davis&rft.aufirst=Anthony J&rft.au=Yan Zhen&rft.au=Martinez Bobbie&rft.au=Mumby Marc C&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2414307&rfr_id=info:sid/en.wikipedia.org:CDC6" class="Z3988">

Further reading

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