Wikipedia

CD96

CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene.[5] CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1).[6] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation[citation needed]. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.[7]

CD96
Identifiers
AliasesCD96, TACTILE, CD96 molecule
External IDsOMIM: 606037; MGI: 1934368; HomoloGene: 68489; GeneCards: CD96; OMA:CD96 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10225

84544

Ensembl

ENSG00000153283

ENSMUSG00000022657

UniProt

P40200
Q8WUE2

Q3U0X8

RefSeq (mRNA)

NM_005816
NM_198196
NM_001318889

NM_032465

RefSeq (protein)

NP_001305818
NP_005807
NP_937839
NP_001305818.1

NP_115854

Location (UCSC)Chr 3: 111.29 – 111.67 MbChr 16: 45.86 – 45.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
For the isotope of cadmium (Cd-96 or 96Cd), see Cadmium-96.

Function

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The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153283 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022657 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CD96 molecule". Retrieved 2018-07-03.
  6. ^ Fuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.359-366&rft.date=2006-10&rft_id=info:doi/10.1016/j.semcancer.2006.07.002&rft_id=info:pmid/16904340&rft.aulast=Fuchs&rft.aufirst=A&rft.au=Colonna, M&rfr_id=info:sid/en.wikipedia.org:CD96" class="Z3988">
  7. ^ Martinet L, Smyth MJ (April 2015). "Balancing natural killer cell activation through paired receptors". Nature Reviews. Immunology. 15 (4): 243–254. doi:10.1038/nri3799. PMID 25743219. S2CID 20825600.243-254&rft.date=2015-04&rft_id=https://api.semanticscholar.org/CorpusID:20825600#id-name=S2CID&rft_id=info:pmid/25743219&rft_id=info:doi/10.1038/nri3799&rft.aulast=Martinet&rft.aufirst=L&rft.au=Smyth, MJ&rfr_id=info:sid/en.wikipedia.org:CD96" class="Z3988">

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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