CCAR1

CCAR1
Identifiers
Aliases	CCAR1, cell division cycle and apoptosis regulator 1
External IDs	OMIM: 612569; MGI: 1914750; HomoloGene: 10086; GeneCards: CCAR1; OMA:CCAR1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	68,792,377 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,628,065 bp
RNA expression pattern
	Top expressed in
	sperm; ; pancreatic ductal cell; ; visceral pleura; ; parietal pleura; ; ventricular zone; ; sural nerve; ; pylorus; ; Achilles tendon; ; ganglionic eminence; ; seminal vesicula;
	Top expressed in
	genital tubercle; ; tail of embryo; ; Rostral migratory stream; ; human fetus; ; ciliary body; ; migratory enteric neural crest cell; ; maxillary prominence; ; abdominal wall; ; pineal gland; ; mandibular prominence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transcription corepressor activity; nuclear receptor coactivator activity; transcription coactivator activity; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; nucleoplasm; nucleus;
Biological process	positive regulation of cell migration; mRNA splicing, via spliceosome; cell cycle; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of cell population proliferation; apoptotic process; negative regulation of nucleic acid-templated transcription; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	55749
	67500
	ENSG00000060339
	ENSMUSG00000020074
	Q8IX12
	Q8CH18
	NM_001282959; NM_001282960; NM_018237
	NM_026201
	NP_001269888; NP_001269889; NP_060707
	NP_080477
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division cycle and apoptosis regulator protein 1 is a protein that in humans is encoded by the CCAR1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000060339 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020074 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rishi AK, Zhang L, Boyanapalli M, Wali A, Mohammad RM, Yu Y, Fontana JA, Hatfield JS, Dawson MI, Majumdar AP, Reichert U (Aug 2003). "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437". J Biol Chem. 278 (35): 33422–35. doi:10.1074/jbc.M303173200. PMID 12816952.33422-35&rft.date=2003-08&rft_id=info:doi/10.1074/jbc.M303173200&rft_id=info:pmid/12816952&rft.aulast=Rishi&rft.aufirst=AK&rft.au=Zhang, L&rft.au=Boyanapalli, M&rft.au=Wali, A&rft.au=Mohammad, RM&rft.au=Yu, Y&rft.au=Fontana, JA&rft.au=Hatfield, JS&rft.au=Dawson, MI&rft.au=Majumdar, AP&rft.au=Reichert, U&rft_id=https://doi.org/10.1074%2Fjbc.M303173200&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
^ "Entrez Gene: CCAR1 cell division cycle and apoptosis regulator 1".

External links

Human CCAR1 genome location and CCAR1 gene details page in the UCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.97-105&rft.date=2004&rft_id=https://api.semanticscholar.org/CorpusID:11683986#id-name=S2CID&rft_id=info:pmid/14743216&rft_id=info:doi/10.1038/ncb1086&rft.aulast=Bouwmeester&rft.aufirst=T&rft.au=Bauch, A&rft.au=Ruffner, H&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6170–5. Bibcode:2004PNAS..101.6170M. doi:10.1073/pnas.0307459101. PMC 398631. PMID 15069192.6170-5&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC398631#id-name=PMC&rft_id=info:pmid/15069192&rft_id=info:doi/10.1073/pnas.0307459101&rft_id=info:bibcode/2004PNAS..101.6170M&rft.aulast=McDonald&rft.aufirst=ER&rft.au=El-Deiry, WS&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC398631&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.375-81&rft.date=2004&rft_id=info:pmid/15164054&rft_id=info:doi/10.1038/nature02462&rft_id=info:bibcode/2004Natur.429..375D&rft.aulast=Deloukas&rft.aufirst=P&rft.au=Earthrowl, ME&rft.au=Grafham, DV&rft_id=https://doi.org/10.1038%2Fnature02462&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.12130-5&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446#id-name=PMC&rft_id=info:pmid/15302935&rft_id=info:doi/10.1073/pnas.0404720101&rft_id=info:bibcode/2004PNAS..10112130B&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Jedrychowski, M&rft.au=Schwartz, D&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
Rishi AK, Zhang L, Yu Y, et al. (2006). "Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor". J. Biol. Chem. 281 (19): 13188–98. doi:10.1074/jbc.M512279200. PMID 16543231.13188-98&rft.date=2006&rft_id=info:doi/10.1074/jbc.M512279200&rft_id=info:pmid/16543231&rft.aulast=Rishi&rft.aufirst=AK&rft.au=Zhang, L&rft.au=Yu, Y&rft_id=https://doi.org/10.1074%2Fjbc.M512279200&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.635-48&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:7827573#id-name=S2CID&rft_id=info:pmid/17081983&rft_id=info:doi/10.1016/j.cell.2006.09.026&rft.aulast=Olsen&rft.aufirst=JV&rft.au=Blagoev, B&rft.au=Gnad, F&rft_id=https://doi.org/10.1016%2Fj.cell.2006.09.026&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">
Zhang L, Levi E, Majumder P, et al. (2007). "Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo". Mol. Cancer Ther. 6 (5): 1661–72. doi:10.1158/1535-7163.MCT-06-0653. PMID 17513614.1661-72&rft.date=2007&rft_id=info:doi/10.1158/1535-7163.MCT-06-0653&rft_id=info:pmid/17513614&rft.aulast=Zhang&rft.aufirst=L&rft.au=Levi, E&rft.au=Majumder, P&rft_id=https://doi.org/10.1158%2F1535-7163.MCT-06-0653&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000060339 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020074 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12816952-5] Rishi AK, Zhang L, Boyanapalli M, Wali A, Mohammad RM, Yu Y, Fontana JA, Hatfield JS, Dawson MI, Majumdar AP, Reichert U (Aug 2003). "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437". J Biol Chem. 278 (35): 33422–35. doi:10.1074/jbc.M303173200. PMID 12816952.33422-35&rft.date=2003-08&rft_id=info:doi/10.1074/jbc.M303173200&rft_id=info:pmid/12816952&rft.aulast=Rishi&rft.aufirst=AK&rft.au=Zhang, L&rft.au=Boyanapalli, M&rft.au=Wali, A&rft.au=Mohammad, RM&rft.au=Yu, Y&rft.au=Fontana, JA&rft.au=Hatfield, JS&rft.au=Dawson, MI&rft.au=Majumdar, AP&rft.au=Reichert, U&rft_id=https://doi.org/10.1074%2Fjbc.M303173200&rfr_id=info:sid/en.wikipedia.org:CCAR1" class="Z3988">

[entrez-6] "Entrez Gene: CCAR1 cell division cycle and apoptosis regulator 1".

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CCAR1

References

External links

Further reading